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Signs/symptoms of Viral Meningitis:
- Sudden high fever, severe meningeal inflammation, increased WBCs in CSF
- Inflammation causes most signs/symptoms
90% of cases caused by RNA viruses in the genus Enterovirus (Coxsackie A virus, Coxsackie B virus, Echovirus)
Signs/symptoms of Arboviral Encephalitis:
- Arthopod-borne virus
- mild, cold-like symptoms
Caused by: arboviruses; mosquitoes (blood-sucking arthropods)
Signs/symptoms of Botulism:
- Foodborne: progressive paralysis on both sides of the body; slow recovery from growth of new nerve cell endings
- Infant: results from the ingestion of endopsores, nonspecific symptoms
- Wound: contamination of a wound by endospores; symptoms similar to foodborne
Caused by: Clostridium botulinum
What happens in Botulism?
Botulism toxin present in the neuromuscular junction prevents vesicles from releasing acetylcholine; paralysis
Signs/symptoms of Tetanus:
- Tightening of the jaw (lockjaw)
- Spasms and contractions may spread to other muscles
- Irregular heartbeat and blood pressure and profuse sweating may occur
Caused by: Clostridium tetani
What happens in Tetanus?
Tetanospasmin (tetanus toxin) blocks release of inhibitory neurotransmitter; muscles can’t relax
Signs/symptoms of Hansen’s Disease:
- Tuberculoid leprosy: nonprogressive form of the disease; strong cell-mediated immune response
- Lepromatous leprosy: more virulent form of the disease; weak cell-mediated immune response
Caused by: Mycobacterium leprae
Signs/symptoms of Polio:
- Asymptomatic infections (90% of cases)
- Minor polio: nonspecific symptoms
- Nonparalytic polio: muscle spasms and back pain
- Paralytic polio: produces paralysis
- Postpolio syndrome can be debilitating
Caused by: Poliovirus
Signs/symptoms of Brucellosis:
- Fluctuating fever that spikes every afternoon
- Endotoxin causes some of the signs and symptoms
Caused by: Brucella melitensis
Signs/symptoms of Yersinia pestis:
Cause of: Plague
- Bubonic plague: characterized by enlarging lymph nodes called buboes
- Pneumonic plague: occurs when the bacterium spreads to lungs; difficult breathing
Signs/symptoms of Infectious mononucleosis:
Cause of: Epstein-Barr virus (EBV or HHV-4)
- Severe sore throat and fever occur initially
- Followed by swollen lymph nodes, fatigue, appetite loss, and a skin rash
Signs/symptoms of Schistosomiasis:
- Swimmer’s itch at infection site
- Eggs deposited throughout body can cause other symptoms
Caused by: 3 species of Schistosoma
Signs/symptoms of Diphtheria:
- Sore throat, localized pain, fever
- Presence of a pseudo membrane that can obstruct airways
Caused by: Corynebacterium diphtheriae
Characteristics/virulence factors of Neisseria meningitidis:
- Gram negative cocci; known as meningococcus
- Fimbriae, capsule, and lipoligosaccharide help the bacteria attach to cells (Neisseria cells without these structures are avirulent. Capsule protects bacteria from phagocytic lysis)
One cause of: Bacterial Meningitis
Characteristics/virulence factors of Francisella tularensis:
- Can survive within infected cells
-Endotoxin causes many signs and symptoms - Diverse host ranges from mammals, birds, fish, ticks, insects
Causes: Tularemia
Characteristics/virulence factors of Streptococcus pyogenes:
- Group A streptococci
- Virulence factors: M proteins, hyaluronic acid capsule, streptokinases, C5a peptidase, pyrogenic toxins, streptolysins
- Causes Streptococcal Respiratory Diseases
Characteristics/virulence factors of Streptococcus pneumoniae:
- Gram positive coccus
- Leading cause of meningitis in adults
- Capsule protects bacteria from digestion by phagocytes
- Enzymes and toxins enable bacteria to counteract immune defenses
One cause of: Bacterial Meningitis
Causes: Pneumococcal Pneumonia
Virulence factors: adhesions, capsule, pneumolysin
At risk groups of Streptococcus agalactiae:
- Normal vaginal microbiota in some women
- Acquired during birth
One cause of: Bacterial Meningitis
At risk groups of Listeria monocytogenes:
- Pregnant women, fetuses, newborns, elderly, immunocompromised
- Not transmitted among humans except from mother to fetus
- Transmitted via contaminated food
One cause of: Bacterial Meningitis
At risk groups of Neisseria meningitidis:
- Spread among individuals in barracks and dorms; can become epidemic
One cause of: Bacterial Meningitis
At risk groups of Toxoplasma:
- Individuals with poor immunity
- Fetal infections can cause numerous conditions
Caused by: Toxoplasma gondii
At risk groups of Pneumocystis Pneumonia (PCP):
- Common in AIDS patients
- Transmitted by inhalation of droplets containing the fungus
Caused by: Pneumocystis jirovecii
Diagnosis of Viral Meningitis:
Characteristic signs and symptoms in the absence of bacteria in the CSF
Diagnosis of Viral Encephalitis:
Based on signs and symptoms; confirmed by presence of arbovirus-specific antibodies in CSF
Treatment of Rabies:
Treated with human rabies immunoglobulin, vaccine injections, and infection site cleaning
Caused by: Rabies virus (ssRNA virus)
Treatment of Pertussis:
- Also called “Whooping cough”
- Treatment is primarily supportive
Caused by: Bordetella pertussis
Reservoir/host of Viral Encephalitis:
- Vector: mosquito (blood-sucking arthropods
- Prevent by eliminating stagnant water
Reservoir/host of Yellow fever:
- Transmitted via the bite of an infected Aedes mosquito
- Caused by: Yellow Fever Virus
Reservoir/host of Dengue fever:
- Vector: Aedes mosquitoes
- Caused by 4 strains of Dengue viruses
Reservoir/host of Hantavirus Pulmonary Syndrome (HPS):
- Transmitted from mice via inhalation
- Caused by Hantavirus
- Hantavirus travels throughout the body via the blood
Transmission of Primary Amebic Menigoencephalitis:
- Enters host through abrasions on the skin or eyelid or by inhalation of contaminated water
Caused by: Acanthamoeba and Naegleria
Transmission of Blastomycosis:
- Enters body through inhalation of dust carrying fungal spores
Caused by: Blastomyces dermatitidis
Transmission of Legionella pneumophila:
- Survives in domestic water sources
Causes: Legionnaires’ Disease
Septicemia:
Bacteremia:
Toxemia:
- Septicemia: any microbial infection of the blood that produces illness; caused more often by Gram negative bacteria; due to direct inoculation of bacteria into the blood
- Bacteremia: bacterial septicemia
- Toxemia: release of bacterial toxins into the blood (exotoxin: released from living microorganisms; endotoxins: released from Gram-negative bacteria)
Effects of Lipid A:
Triggers fever, inflammation, shock, and clotting
Signs/Symptoms of Malaria:
- Signs/symptoms associated with parasite’s life in erythrocytes
- Fever, chills, diarrhea, headache; anemia, weakness, and fatigue gradually occur
Most severe malaria…
Plasmodium falciparum causes the most severe malaria but there are at least four that can cause malaria
At risk groups of Malaria:
- Children are particularly vulnerable to infection