Final Exam: Treatments Flashcards

1
Q

Paxlovid: who should use it?

A

Positive for COVID
12+ years old and 40+ kg
=< 5 days since symptom onset
Have 1+ risk factor for severe illness progression

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2
Q

Paxlovid: what is the dosing?

A

Two 150 mg tabs nirmatrelvir + one 100 mg tab ritonavir
BID
X 5 days

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3
Q

Molnupiravir: MAINLY beneficial at decreasing what?

A

Hospitalizations or death from serious illness

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4
Q

Molnupiravir: who SHOULD take?

A

Positive COVID
Mild-moderate illness
18+ years old
1+ risk of severe illness progression

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5
Q

Molnupiravir: who should NOT take?

A

X PREGNANT X
Hospitalized patients
Prophylaxis
Longer than 5 days

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6
Q

Molnupiravir: what is the dose?

A

ONE TIME 200 mg tablet with high fat meal*

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7
Q

Remdesivir: what is the dose?

A

200 mg IV loading dose
100 mg IV maintenance dose for 5-10 days

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8
Q

Remdesivir: what is the GFR cutoff?

A

<30

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9
Q

Remdesivir: originally used for what?

A

Ebola

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10
Q

Remdesivir: hospital or outpatient? Oxygen treatment or no?

A

Hospital only
Can be used in patients w/ O2 treatment or not

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11
Q

What should ALL COVID patients receive?

A

Dexamethasone

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12
Q

Corticosteroids: what dose should be used?

A

Dexamethasone 6 mg IV or PO daily x 10 days or discharge

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13
Q

Tocilizumab: what class of drug is it?

A

IL-6 antagonist

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14
Q

Tocilizumab: what is the dose?

A

ONE DOSE 8 mg/kg IV over 1 hour

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15
Q

Tocilizumab: hospital or outpatient? Oxygen treatment or no?

A

Hospital only
Oxygen treatment (conventional, HFNC or ECMO) patients only

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16
Q

Baricitinib: what class of drug is it?

A

Kinase inhibitor

17
Q

Baricitinib: what symptom does it primarily treat?

A

Inflammation

18
Q

Baricitinib: what is the dose?

A

4 mg PO daily x 14 days or discharge

19
Q

Baricitinib: hospital or outpatient? Oxygen therapy or no?

A

Hospital only
Oxygen treatment (conventional, HFNC or ECMO) patients only

20
Q

If patient with COVID is admitted to the ICU under normal circumstances, should we administer therapeutic-dose anticoagulant?

A

No

21
Q

If patient with COVID is admitted to the ICU with THIS LAB RESULT, we should administer therapeutic-dose anticoagulant

A

> = 4x D-dimer

22
Q

What patients should receive prophylactic anticoagulation?

A

All!

23
Q

What parasite class causes malaria?

A

Plasmodium

24
Q

Malaria: what is the go-to treatment regimen?

A

Artemisinin backbone combo:

Ie)
Arthemeter + lumefatrine
Artesunate + amodiaquine
Artesunate + mefloquine

25
Q

What are the administration routes for arthemeter and artesunate?

A

Arthemeter = IM, PO
Artesunate = IV, PO

26
Q

Malaria: what is the duration of treatment?

A

3 days

27
Q

Syphilis: What are the stages?

A

Primary = chancre at site
Secondary (6 months) = rash, fatigue, malaise, sore throat
Early latency (1 year) = asymptomatic
Late latency (>1 year) = progressive organ involvement

28
Q

Syphilis: what is the treatment?

A

ONCE DOSE IM benzathine penicillin G 2.4 million units

29
Q

Chlamydia: what is the treatment?

A

Doxycycline 100 mg PO BID x 7 days
(Alt. = Azithromycin)

30
Q

Gonnorhea: what is the treatment?

A

ONCE DOSE Ceftriaxone 250 mg IM
(Alt. = ONCE cefixime 800 mg PO)

31
Q

Pelvic Inflammatory Disease: what is the treatment? (Inpatient vs outpatient)

A

Inpatient = cefoxitin IV + doxycycline po
(Alt. Clindamycin IV + gentamicin)

Outpatient = ceftriaxone IM + doxycycline po

32
Q

EPT: if the patient ONLY has chlamydia (no gonorrhea), what should they take?

A

Azithromycin 1g PO ONCE

33
Q

EPT: if the patient has gonorrhea, what should they take?

A

Cefixime 400 mg PO + Azithromycin 1g PO ONCE