Final Exam: Treatments Flashcards
Paxlovid: who should use it?
Positive for COVID
12+ years old and 40+ kg
=< 5 days since symptom onset
Have 1+ risk factor for severe illness progression
Paxlovid: what is the dosing?
Two 150 mg tabs nirmatrelvir + one 100 mg tab ritonavir
BID
X 5 days
Molnupiravir: MAINLY beneficial at decreasing what?
Hospitalizations or death from serious illness
Molnupiravir: who SHOULD take?
Positive COVID
Mild-moderate illness
18+ years old
1+ risk of severe illness progression
Molnupiravir: who should NOT take?
X PREGNANT X
Hospitalized patients
Prophylaxis
Longer than 5 days
Molnupiravir: what is the dose?
ONE TIME 200 mg tablet with high fat meal*
Remdesivir: what is the dose?
200 mg IV loading dose
100 mg IV maintenance dose for 5-10 days
Remdesivir: what is the GFR cutoff?
<30
Remdesivir: originally used for what?
Ebola
Remdesivir: hospital or outpatient? Oxygen treatment or no?
Hospital only
Can be used in patients w/ O2 treatment or not
What should ALL COVID patients receive?
Dexamethasone
Corticosteroids: what dose should be used?
Dexamethasone 6 mg IV or PO daily x 10 days or discharge
Tocilizumab: what class of drug is it?
IL-6 antagonist
Tocilizumab: what is the dose?
ONE DOSE 8 mg/kg IV over 1 hour
Tocilizumab: hospital or outpatient? Oxygen treatment or no?
Hospital only
Oxygen treatment (conventional, HFNC or ECMO) patients only
Baricitinib: what class of drug is it?
Kinase inhibitor
Baricitinib: what symptom does it primarily treat?
Inflammation
Baricitinib: what is the dose?
4 mg PO daily x 14 days or discharge
Baricitinib: hospital or outpatient? Oxygen therapy or no?
Hospital only
Oxygen treatment (conventional, HFNC or ECMO) patients only
If patient with COVID is admitted to the ICU under normal circumstances, should we administer therapeutic-dose anticoagulant?
No
If patient with COVID is admitted to the ICU with THIS LAB RESULT, we should administer therapeutic-dose anticoagulant
> = 4x D-dimer
What patients should receive prophylactic anticoagulation?
All!
What parasite class causes malaria?
Plasmodium
Malaria: what is the go-to treatment regimen?
Artemisinin backbone combo:
Ie)
Arthemeter + lumefatrine
Artesunate + amodiaquine
Artesunate + mefloquine
What are the administration routes for arthemeter and artesunate?
Arthemeter = IM, PO
Artesunate = IV, PO
Malaria: what is the duration of treatment?
3 days
Syphilis: What are the stages?
Primary = chancre at site
Secondary (6 months) = rash, fatigue, malaise, sore throat
Early latency (1 year) = asymptomatic
Late latency (>1 year) = progressive organ involvement
Syphilis: what is the treatment?
ONCE DOSE IM benzathine penicillin G 2.4 million units
Chlamydia: what is the treatment?
Doxycycline 100 mg PO BID x 7 days
(Alt. = Azithromycin)
Gonnorhea: what is the treatment?
ONCE DOSE Ceftriaxone 250 mg IM
(Alt. = ONCE cefixime 800 mg PO)
Pelvic Inflammatory Disease: what is the treatment? (Inpatient vs outpatient)
Inpatient = cefoxitin IV + doxycycline po
(Alt. Clindamycin IV + gentamicin)
Outpatient = ceftriaxone IM + doxycycline po
EPT: if the patient ONLY has chlamydia (no gonorrhea), what should they take?
Azithromycin 1g PO ONCE
EPT: if the patient has gonorrhea, what should they take?
Cefixime 400 mg PO + Azithromycin 1g PO ONCE
