Final Exam Review - Exam 4 Flashcards

1
Q
1. Which dosage form is anticipated to stay in the fed stomach for a longer period of
time?
A. Pellets
B. Liquids
C. Disintegrated tablets
D. Extended release dosage forms
A

D. Extended release dosage forms

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2
Q
  1. In order that the dosage form (drug) will reach the intestine rapidly, how should the drug be taken?
    A. With food
    B. With water
A

B. With water

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3
Q
  1. Passive diffusion is the preferred route of transport for relatively small___________
    A. Hydrophilic molecules
    B. Lipophilic molecules
A

B. Lipophilic molecules

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4
Q
  1. In active transport, the molecules move from regions of:
    A. Low concentration to those of high concentration
    B. High concentration to those of low concentration
A

A. Low concentration to those of high concentration

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5
Q
5. Transporters for which of the following compounds would be the most relevant for the absorption of drugs?
A. Short peptides
B. Sugars
C. Electrolytes
D. Vitamins (B1, B2, B12)
E. Bile salts
A

A. Short peptides

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6
Q
  1. Which mechanism(s) require (s) a concentration gradient of the drug as its/their driving force?
    A. Passive Diffusion only
    B. Carrier-mediated transport: Active Transport
    C. Carrier-mediated transport: Facilitated Diffusion only
    D. A and B
    E. A and C
A

E. A and C

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7
Q
  1. The diffusion coefficient, D, of the drug in the GI fluids may be ____________ by the presence of food
    A. Increased
    B. Decreased
A

B. Decreased

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8
Q
  1. An increase in gastric and/or intestinal motility may __________ the dissolution rate of a sparingly soluble drug
    A. Increase
    B. Decrease
A

A. Increase

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9
Q
  1. Solubility of weak acids is:
    A. Higher in stomach than small intestine
    B. Higher in small intestine than stomach
A

B. Higher in small intestine than stomach

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10
Q
  1. Which drug is more appropriate to treat toothache?
    A. Naproxen
    B. Naproxen sodium
    C. Naproxen and naproxen sodium are equally appropriate
A

B. Naproxen sodium

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11
Q
  1. Cyclodextrin complexes are:
    A. Reversible
    B. Irreversible
A

A. Reversible

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12
Q
  1. When a drug is unstable in gastric fluid, to minimize its degradation in gastric fluid, should you increase/decrease its dissolution in gastric fluid?
    A. Increase
    B. Decrease
A

B. Decrease

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13
Q
  1. Choose the correct statement:
    A. Most drugs are weak electrolytes
    B. Most drugs are strong electrolytes
    C. The number of drugs that are weak electrolytes is approximately similar
    to the number of drugs that are strong electrolytes
A

A. Most drugs are weak electrolytes

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14
Q
  1. Which form of drugs that are weak acids or bases will better penetrate through the GI epithelium?
    A. Ionized
    B. Unionized
    C. Ionization does not affect penetration through GI epithelium
A

B. Unionized

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15
Q
  1. Drugs that are poorly lipid soluble (=polar) (log P
A

A. Paracellular pathway

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16
Q
  1. Which statement is true?
    A. Most drugs are more stable in liquid dosage forms
    B. Most drugs are more stable in solid dosage forms
    C. There is no connection between drug stability and dosage form
A

B. Most drugs are more stable in solid dosage forms

17
Q
  1. One has two pieces: a longer body and a shorter cap; the other has only one piece; which is which?
    A. Hard=2 pieces; soft=1 piece
    B. Hard=1 piece; soft= 2 pieces
A

A. Hard=2 pieces; soft=1 piece