Final Exam Review - Exam 3 Flashcards
1
Q
- “Solubility depends on how fast a solution is formed.” This statement is:
A. True
B. False
A
B. False
2
Q
2. Which of the following is the most relevant approach for controlling solubility? A. Complexation B. Particle Size C. Chemical modification D. Solubilization E. None of the above
A
C. Chemical modification
3
Q
3. Semipolar solvents are capable of dissolving: A. Polar substances only B. Nonpolar substances only C. Both polar and nonpolar substances D. Semipolar substances only
A
C. Both polar and nonpolar substances
4
Q
- There is a general trend of _____________ aqueous solubility with increasing boiling point.
A. Increasing
B. Decreasing
A
B. Decreasing
5
Q
5. Adjusting the pH to a value at which unionized molecules are produced in sufficient concentration to exceed the solubility of this form, may lead to A. Miscibility B. Solubilization C. Precipitation D. Dissolution E. Wetting
A
C. Precipitation
6
Q
- Non-steroidal anti-inflammatory agents (NSAIDs) ___________ soluble in acidic solutions than in alkaline solutions
A. More
B. Less
A
B. Less
7
Q
- 1% solution of phenobarbital sodium is soluble at pH values in the ______________ range
A. Acidic
B. Alkaline
A
B. Alkaline
8
Q
- “Some suspensions and emulsions may contain a range of particle sizes such that the smaller particles lie within the colloidal range, whereas the larger ones are classified as coarse particles.” This statement is
A. True
B. False
A
A. True
9
Q
- “Lyophilic colloids are always formed in aqueous dispersion media.” This statement
is
A. True
B. False
A
B. False
10
Q
- “For polymers acting as hydrophilic colloids each particle is made from a single molecule.” This statement is
A. True
B. False
A
A. True
11
Q
- “The dispersion process of lyophobic dispersion is spontaneous.” This statement is A. True
B. False
A
B. False
12
Q
- At concentrations below CMC, amphiphiles will first go to the:
A. Air-water interface
B. Bulk Phase
C. A and B at approximately equal amounts
A
A. Air-water interface
13
Q
- Which component of Adult Infuvite Multiple Vitamins for Infusion is most likely to be solubilized?
A. Ascorbic acid (Vitamin C)
B. Vitamin A palmitate
C. Thiamine hydrochloride (vitamin B1)
D. Riboflavin 5-phosphate sodium (vitamin B2)
E. Folic Acid
A
B. Vitamin A palmitate
14
Q
16. Which inactive ingredient may cause solubilization? A. Polysorbate 80 B. Propylene glycol C. Anhydrous citric acid D. Sodium citrate E. Sodium hydroxide
A
A. Polysorbate 80
15
Q
- Which statement is true for microemulsions?
A. They may be formed spontaneously by agitating the oil and water phases with carefully selected surfactants
B. Their preparation requires the input of considerable amounts of mechanical energy, which may be supplied by colloid mills, homogenizers, or ultrasonic generators
A
A. They may be formed spontaneously by agitating the oil and water phases with carefully selected surfactants
16
Q
- Liposomes are able to accommodate
A. Water-soluble drugs
B. Lipid-soluble drugs
C. Both water- and lipid-soluble drugs
A
C. Both water- and lipid-soluble drugs
17
Q
- Uptake by the MPS is
A. Always undesirable
B. May sometimes be desirable
A
B. May sometimes be desirable
18
Q
- Which of the following disadvantages is the primary disadvantage of liposomes?
A. Low encapsulation efficiency of some drugs
B. Challenging scale up and sterilization
C. Rapid removal from the blood following intravenous administration by cells
of the MPS
D. May require lyophilization for stabilization
E. Short half-life
A
C. Rapid removal from the blood following intravenous administration by cells
of the MPS
19
Q
- “DepoCyt is a colloidal dispersion system”. This statement is
A. True
B. False
A
B. False
