Final Exam Prep Flashcards
The blood test most commonly used to confirm the existance of heart muscle damage is:
Creatine Kinase
The diagnosis of acute myocardial infarction consists of the following “triad”:
chest pain,
ECG changes,
Elevation of biomarkers
An ideal marker should appear in the blood quickly after an infarct and then be rapidly cleared from the blood.
T / F
False
Marker Responses to MI curve, which one is the highest one (B)?
Cardiac Troponin
Marker Responses to MI curve, which one is the lowest one (D)?
Cardiac troponin after unstable angina
Marker Responses to MI curve, which one is the Average one (C)?
CKMB
Marker Responses to MI curve, which one is the narrowest one (A)?
Myoglobin
Creatine Kinase (CK) lacks specificity for cardiac damage and, therefore, needs to be augmented with the CK-MB fraction.
T / F
True
CK-MM (98%) :
CK-MB (1%)
Skeletal muscle expression of creatine kinase
CK-MM (70%) :
CK-MB (30%)
Cardiac myocardial expression of creatine kinase
CK-BB
Expressed mainly in the tissues, little significance in blood straem
CK/CPK
catalyzes the conversion of creatine to phosphocreatine degrading ATP to ADP
Troponin-C (TnC)
binds to Ca++ ions to produce a conformational change in TnI
Troponin-I (TnI)
binds to actin in thin myofilaments to stabilze troponin-tropomyosin complex
Troponin-T (TnT)
binds to tropomyosin forming the troponin-tropomyosin complex
Tropomyosin
a thin filament element
Troponin as a marker: Which Troponin have studies failed to find a source outside the heart?
Troponin-i
Which biomarker may provide prognostic information (ie. peak levels corelate with infarct size)
Tni