Final Exam - Cumulative Flashcards
most executive functions have been associated with which part of the brain?
prefrontal cortex
are the boundaries of the prefrontal cortex within the frontal well or poorly defined?
poorly defined
miller and cohen suggest that the PFC serves to enforce rules that are ___ to a given situation
-ex. it’s ok to wipe food off your child’s mouth, but not your uber driver’s mouth
appropriate
the PFC also manages ____ to the rules
-ex. it’s ok (heroic even) to grab a stranger’s arm and yank them (if they’re about to step in front of a bus)
exceptions
relative positions of regions within the PFC:
___ = toward midline
medial
relative positions of regions within the PFC:
___ = away from midline
lateral
relative positions of regions within the PFC:
___ = toward back (or top of head)
dorsal
relative positions of regions within the PFC:
___ = toward belly (or jaw of head)
ventral
connectivity tracing studies reveal distinct ___ and ___ PFC networks, along with overlapping regions of shared connectivity
lateral and medial
___ PFC networks support: “general purpose peerceptual-motor preparatory, goal monitoring”
lateral PFC networks
___ PFC networks support: “emotion/memory integration, physical awareness”
medial PFC networks
true or false: both PFC networks depend on “motor control, conflict monitoring”
true
brain lesion data links ___ PFC damage with a lack of action, initiative, and planning
lateral
patients respond OK to questions, show normal-ish IQ, but fail to prepare for the future, stick to a task, or maintain attention for longer than a few moments. if left alone, they sit down and don’t initiate any action at all
dysexecutive syndrome
___ PFC damage is linked with excessive, impulsive action, without self awareness
medial PFC damage
people with damage to the medial aspects of the PFC typically show ___ syndrome
disinhibition syndrome
deficits in controlling aspects of behavior
-they have problems integrating emotional information into decision making processes
-they are unaware of their inappropriate behavior, and appear manic, impulsive, and disorganized
disinhibition syndrome
____ medial PFC lesions can lead to bizarre behavior that is overly influenced by contextual cues
-these “environmental dependency” patients primarily react to whatever is around them, without any appreciation of social rulees
anterior medial PFC
ex. of anterior medial PFC lesions
walking into a room in which there is a picture leaning against the wall, along with a hammer and some nails - the person will immediately start hanging up the photo
a common method of evoking rule conflict in the lab
stroop task
true or false: relating and resolving conflicting rules is associated with a well functioning dorsomedial PFC
true
the ___ PFC is strongly linked to working memory, which involves the maintenance and manipulation of relevant information, along with the exclusion of irrelevant information
dorsolateral PFC (DLPFC)
do we see little or lots of evidence for DLPFC activity in working memory tasks in fMRI studies?
lots of
an alternative model by Cowan suggests that working memory is just the subset of ___ long term memory items (and conceptually associated items) that have been used in the last few minutes
genetic
alternative model proposed by Cowan: this smaller subset of all items in working memory are capable of being manipulated by the “central executive” - or ___
consciousness
the ___ also contributes to working memory
basal ganglia
a series of paired objects are presented, and your task is to decide if one of them matches the last set
dynamic working memory task
is the basal ganglia enhanced or hindered by difficult working memory trials?
enhanced
is rule learning handled solely in the prefrontal cortex?
no ; the basal ganglia makes a real contribution
is there evidence for distinct PFC-basal-ganglia-thalamic networks that support “executive” functions within motor, cognitive, and emotional domains?
yes
motor loop (3 components)
- primary motor
- premotor
- supplementary motor cortex
prefrontal loop
dorsolateral prefrontal cortex
affective loop (2 components)
anterior cingulate and orbitofrontal cortex
language is most strongly associated with which two areas of the brain?
left IFG (broca’s area) and L posterior auditory association cortex (wernicke’s area)
broca’s area
left IFG
wernicke’s area
L posterior auditory association cortex
relationship between broca’s area and wernicke’s area
densely interconnected, but independently support different aspects of language processing
damage to broca’s area
production deficits
damage to wernicke’s area
comprehension deficits
aprosodia (“robotic speech”) results from ___ hemisphere damage
right hemisphere
efficient language processing is strongly dependent on ___ we generate about upcoming words within a sentence
-this greatly speeds our ability to process language
expectations
if we present folks with a series of words, we can see an ERP that appears after a word that doesn’t meet these expectations, an ____
-this is distinct from the P300 ERP
N400
only ___ based violations trigger the N400
meaning-based
____ deviance (ex. a different font, or spoken by a different person) evoke a P300-like ERP
non-semantic
the bigger the deviation, the larger the ___
N400
any given language is made up of just ___ to ___ phones (or speech sounds)
30-100
there are only around ___ phones in all languages
200
infants lose the ability to distinguish phones outside their native language by ~___ years of age
~2
what is perceived when someone hears a phone
phoneme
language is not just auditory. we use both the sound and the sight of someone speaking to decipher language. when the sight doesn’t match the sound, we often perceive a third phoneme, not actually present in either modality
the mcgurk effect
when did language emerge in human evolution?
one popular model suggests that our refined speech ability may be due in part to a genetic mutation (____) that happened after humans split from other primates, ~7 million years ago
-we share this gene with all mammals, but ours contain two copies, and this distinction may partially underly our language abilities
FOXP2
in humans without a second FOXP2 copy, is language ability seriously (and specifically) enhanced or compromised?
compromised
darwin’s model of evolved traits is based on ___ - the slow, continuous refinement of traits, with each tweak providing a fitness benefit
gradualism
in contrast, darwin considered human language to have emerged ___, as a result of coincidental genetic mutations in vocal and brain anatomy
suddenly
ghazanfar and others review data suggesting that language could have evolved more gradually (maybe other primates’ language is better than we think)
-specifically, he presents evidence for three features:
- its audiovisual nature (it involves facial cues)
- its rhythmicity (speech timing, meter)
- its turntaking pattern (conversation coordination)
the audiovisual nature of speech:
both humans and macaques respond faster to ___ audio-visual “speech” stimuli than audio or video alone
combined
the rhythmicity of speech:
macaque and human vocalizations have a very similar (and rapid) ___, around 5 per second (HZ)
tempo
a typical speech interaction among people consists of vocal exchanges, gaps of silence, and minimal interruptions
-correspondence in back-and-forth timing between human speech and marmoset vocal ‘conversations’
turn taking pattern of speech
lots of research shows that just two dimensions describe most of people’s conscious response to emotional things
pleasure and arousal
LPP
late positive potential
one of the most reliable effects in human emotion neuroscience is the strong enhancement of a long-lasting ERP called the ___ during emotional scene perception
LPP
the LPP is strongly correlated (~0.95) with the ___ ratings of a scene (not pleasantness)
arousal ratings
EPN
early posterior negativity
the EPN effect is strongest for emotional scenes, but can be evoked by emotional hand gestures, faces, and even emotional ___ (a little)
words
separate from emotion, the EPN is enhanced by ‘simple’ scenes
-the more complicated the scene, the ___ the EPN
weaker
the EPN is often larger for ___ compared to unpleasant scenes, but not the reverse
larger for pleasant
the ___ still showed a ‘pleasure’ bias, where the LPP did not
EPN
victory scenes modulated the EPN well, but nothing like erotica
-we can’t conclude that the EPN shows a pleasure bias
-this suggests a ___-specific enhancement of the EPN
sex-specific
was thee EEPN larger or smaller for nudists than erotica?
larger
EPN modulation: a body part bias?
it appears that the scenes showing the most recognizable, upright bodies tend to drive the ___ EPNs
strongest
the EPN effect replicated
-the largest EPN was evoked by ___ scenes, followed by ___
-this order ___ for the LPP ; largest for erotica, followed by nudists, then mutilations/anim threat
nudist ; erotica ; flips
___ reflects emotion, complexity, and the presence of upright bodies
-our visual systems may be tuned to quickly identify obvious signs of people around us
-may actually include multiple overlapping processees
EPN
___ reflects the intensity of our conscious emotional response to whatever is around us
-it does not reflect complexity, body parts, etc. (only that it’s emotional)
LPP
what brain mechanisms drive these ERP arousal effects?
-work in rats and primates suggests that this enhancement may be driven by feedback from the ___
amygdala
the density of structural connectivity between amygdala and ventral visual cortex reveals heavy ___ connections from amygdala to visual cortex (feedforward path)
feedback
we argue that the ventral visual pathway is a ___ and ___ interactive occipitotemporal network linking early visual areas and the anterior IT cortex (aIT) along multiple routes through which visual information is processed
recurrent and highly interactive
the amygdala ___ back to almost every area in the occipitotemporal network…
-the precise nature of the modulatory signals arising from the amygdala remains unknown, but such diffusely distributed signals are likely to direct attentional resources to the processing of visual stimuli signaling potential danger or other emotionally intense events
projects back
in monkeys and humans, the amygdala shows a burst of emotion-linked activity ~___ms after the presentation of visual emotional cue
-the timing of this amygdala reactivity strongly suggests that it registers emotion before or after visual cortical processing is complete?
~150 ms ; after
using standard fMRI, we found that activity in amygdala and late-stage visual fusiform gyrus (IT) are ___ correlated (0.95)
strongly
the time point at which brain activity is reliably enhanced for emotional scenes is ___ seconds
3.9 seconds
emotional scenes enhanced activity in late-stage ventral visual cortex and amygdala ~___ second earlier than mid-stage visual cortex
~1 second
FP network discriminates emotional scenes before or after amygdala and FG?
after
Granger analyses showed that the amygdala, OFC, and FG are all influencing each other ___ in ___ directions
equally ; both
the entire visual system (outside V1) is enhanced by ___ stimuli
emotional
rapid fMRI data suggests that amygdala and FG ___ this emotional discrimination
initiate
other emotion-sensitive regions (like FP network, OFC) may be “___” of the emotional quality of stimuli from amygdala and FG
“informed”
fMRI work on emotional perception supports a “___ feedback” model of emotional perception
“reentrant feedback”
initial discrimination (first feedback wave) = ___ shift
EPN
second discrimination is more consistent with ___
LPP
a major goal of cognitive neuroscience is to define the relationships between ___
brain structure, brain function, and “consciousness”
brain structure pertains to:
distinct units (how they’re connected)
brain function pertains to:
how the units of the brain operate in real time
consciousness refers to:
an emergent property of brain function
what does EEG stand for?
electroencephalography
electroencephalography (EEG) provides excellent ____ resolution, but poor ____ resolution
temporal ; spatial (when but not exactly where)
millisecond time resolution is characteristic of which noninvasive method?
electroencephalography (EEG)
what does fMRI stand for?
functional magnetic resonance imaging
fMRI provides excellent ___ resolution, but poor ___ resolution
spatial ; temporal (where, but not exactly when)
cognitive neuroscience was born from the combination of three related fields of research on the brain and behavior:
cognitive psychology, neurology, and neurophysiology/neuroimaging
how the brain works in healthy folks
cognitive psychology
cognitive psychology data was explicitly ___ based
behavior (avoids brain)
how brain damage affects behavior in clinical patients
neurology
neurology data was ___ based
deficit (brain-behavior linked)
how healthy brains work in animal models, later including humans with the development of noninvasive brain recording methods
neurophysiology/neuroimaging
true or false: despite lots of investigation, there is little agreement about what consciousness is, and how it might be studied
true
over the last ~2 million years, the human cortex has nearly ____ in size
tripled
cortex = ___
cerebral cortex
the cortex consists of mostly ____ tissue
homogeneous
the cortex is greatly ____ in primates and is critical to (but not sufficient for) “____” cognition
expanded ; “higher-order”
“subcortex” refers to
everything else in the brain
cerebellum, thalamus, basal ganglia, amygdala, hippocampus, midbrain, brainstem, etc
subcortex
the subcortex is ___ in size and internal structure
variable
the subcortex is similar in ____ and ____ with other mammals
structure and function
is the subcortex also essential to higher order cognition?
yes
what are the three main components of the cortical surface?
gyrus, sulcus, and fissure
rounded protrusion of surface cortex (“mountain”)
gyrus
depression in surface cortex (“valley”)
sulcus
a particularly deep sulcus
fissure
___/___ of cortical surface is hidden in sulci and fissures (sulci within sulci)
2/3
cortical folding refers to cortical “___”
cortical “packaging”
cortical folding allows _____, and (maybe) speeds cortical processing time by keeping all brain regions relatively close together
lots of tissue in a small space
4 cortical lobes:
- frontal lobe
- parietal lobe
- temporal lobe
- occipital lobe
the boundary region between cortical and subcortical structures located between the frontal lobe and temporal lobe
insula
the ____ cortex is where the first stage of cortical processing occurs
the “primary sensory” cortex
V1 =
primary visual cortex
V2 =
primary auditory corteex
S1 =
sensory
M1 =
motor
this view states that the thalamus relays sensory and motor signals up to the cortical processing areas, and downstream to the brainstem (except smell)
classic view
recent work has identified that the structure of the thalamus is mostly (~80%) connections from one region of the cortex to another region of the cortex
modern view
the thalamus is heavily involved in ___ connections
cortico-cortical
rather than primarily carrying sensory input to cortex, and motor signals out to the body (“first order” connections”), the thalamus is instead heavily involved in cortico-cortical connections, which are referred to as ____
“higher order” connections
firing modes appear to enhance (____) or inhibit (____) the ‘quality of a connection between brain regions
burst ; tonic
the firing mode is changed by relatively long periods of ___ or ___ input from brain stem and cortex
excitatory ; inhibitory
two divisions of the nervous system
peripheral and central
the autonomic nervous system is part of the ___ nervous system
peripheral
two components of the autonomic nervous system
sympathetic and parasympathetic nervous systems
the ____ nervous system controls self-regulated action of internal organs and glands
autonomic
the ____ nervous system controls AROUSING for non-digestive organ systems
sympathetic
the ____ nervous system controls CALMING for non-digestive organ systems
parasympathetic
the ___ is mostly concerned with housekeeping of the body, but can show strong effects of mental state, such as anticipation or threat reactivity
autonomic nervous system
the ___ branch tends to prepare the body for intense action ; ‘fight or flight’
sympathetic branch
the ____ branch tends to maintain homeostasis and repair ; ‘rest and digest’
parasympathetic branch
our brains make up ____% of our body weight, but consume ____% of our metabolic resources
2% ; 20%
functional imaging is dependent on ___ to track brain activity
blood flow
____ were historically considered “support” cells for neurons
glial cells
we think that there is approximately ___ glial cell for each neuron in the brain
one
excitatory and inhibitory from other neurons
neuronal input
neuronal summation occurs at the ____
axon hillock
how does neuronal output travel
down the axon to synapse with next neuron
the ____ neuron releases neurotransmitter (NT) into the synapse, which modulates activity of the ____ neuron, depending on the neurotransmitter and the receptor type
presynaptic ; postsynaptic
basal forebrain constellation of cholinergic neurons, including basal nucleus of meynert ; dorsolateral pontine tegmental constellation of cholinergic neurons
acetylcholine
is acetylcholine more widespread or more limited?
widespread
is serotonin more widespread or more limited?
widespread
is dopamine more widespread or more limited?
more limited
the function of this neurotransmitter is to enable muscle action, learning, and memory
acetylcholine
with alzheimer’s disease, ACh-producing neurons ____
deteriorate
the function of this neurotransmitter is to influence movement, learning, attention, and emotion
dopamine
excess dopamine receptor activity is linked to ___
schizophrenia
starved of dopamine, the brain produces the tremors and decreased mobility of ____
parkinson’s disease
the function of this neurotransmitter is to affect mood, hunger, sleep, and arousal
serotonin
undersupply of serotonin is linked to ___
depression
____ and some other antidepressant drugs raise serotonin levels
prozac
the function of this neurotransmitter is to help control alertness and arousal
norepinephrine
undersupply of this neurotransmitter can depress mood
norepinephrine
___ is a major inhibitory neurotransmitter
GABA (gamma-aminobutyric acid)
undersupply of this neurotransmitter is linked to seizures, tremors, and insomnia
GABA
____ is a major excitatory neurotransmitter; involved in memory
glutamate
oversupply of this neurotransmitter can overstimulate the brain, producing migraines or seizures (which is why some people avoid MSG in food)
glutamate
“___” and “___” signals (from other neurons) flow through dendrites and cell body to the axon hillock where these signals are averaged together across the cell and over a short period of time (“___”)
“go” and “stop” ; (“summation”)
if ‘go’ signals win, the action potential is the ___ response
all or none
neurons fire at a ___ intensity
fixed
continuous ‘go’ input can increase the firing rate to the limit of the refractory period, perhaps up to ____ times per second
1000
(EEG) records the electrical activity of the ____ in real time
cortex
___ brain activity is missing from EEG
non-cortical
pyramidal neurons in the cortex are oriented in ____
columns
as these neurons sum input from other neurons, their electrical charge becomes more _____ near the outside surface of the cortex
voltage-negative
real time or “____” EEG is useful for tracking long-lasting ‘____’ mental states, like alertness or sleep
“raw” ; ‘tonic’
repeated averaging enhances the small but consistent ‘hidden’ signal
event-related potential (ERP)
true or false: brains will respond pretty much the same on trial one as they do on trial one-thousand
true
true or false: different people’s brains respond differently
false ; they respond similarly
averaging reveals the small, consistent EERP from the noisy EEG background, sort of like averaging the single pictures of a movie - the ____ elements remain
consistent
things that do not change appear ____, while things that do change ____ together
bolder ; blend
with ERP, ____ increases, and ____ decreases
signal ; noise
what does ERP stand for?
event-related potential
early ERP components (~100 ms after stimulus onset) are mostly driven by basic ____ features, like intensity
stimulus
early ERP components are sometimes called ____ components, because they are determined outside the body
exogenous
later ERP components (~250+ ms after stimulus onset) are mostly driven by _____ meaning of stimuli
psychological meaning
later ERP components are sometimes called the _____ components, because they are determined inside the body
endogenous
the first ERP component related to a psychological process was the ____
P300
a big ERP shift ~300 ms after a ‘rare’ event
the P300
the P300 was (and is) a hot area of study because it revealed brain reactivity to all sorts of ‘psychological events,’ including ____ events
missing
the P3 is not a sensory response - the P3 can also reflect a ____
broken expectation
____ is not recognized in the P3 (it often falls into the background) whereas ____ is noticed immediately
consistently ; change
a major problem with ERP
source localization
because the brain is ____, not all parts of the brain are perpendicular to the scalp
folded
the ____ the activity is from the scalp, the ____ the signal (known as volume conduction)
farther ; weaker
as the signal travels, it spreads out, and loses strength (relationship between depth and strength)
volume conduction
true or false: strong EEG voltage could represent weak activity close to the scalp OR strong activity from deeper in the brain
true
EEG/ERP source localization limitation: electrical activity ____ or _____ among folded sections of cortex
combines or cancels
EEG/ERP source localization limitation: source ____ is difficult to distinguish from source depth
strength
EEG/ERP source localization limitation: the exact ____ of sources is unknown
number
EEG/ERP source localization limitation: each person’s head _____ is slightly different
anatomy
what does MEG stand for?
magnetoencephalography
MEG looks for the ____ field that accompanies the voltage field
magnetic
MEG has the same ____ resolution as ERPs, but better ____ resolution than ERPs
temporal ; spatial
what does SQUIDS stand for?
superconducting quantum interference devices
do magnetic fields spread out like electric fields as they pass through the brain and skull?
no
without the smearing effect of volume conduction, MEG is only limited by the ____ and ____ of SQUIDS
size and number
MEG loses sensitivity sharply about ____ cm from the SQUID
5 cm
MEG is effectively blind to ___ brain structures
deep
MEG is really great for ____ cortical tissue, but has no sensitivity to deep cortical stuff
surface
what does fMRI stand for?
functional magnetic resonance imaging
fMRI yields colorful images that represent the ____ of brain activity with good precision, in a way that is easy to grasp
location
3 elements of MRI:
- strong, fixed magnet
- radio emitter and receiver
- weak, variable magnets
magnetic hydrogen protons (in water) align with the field, and spin at a known rate (128 MHz for a 3T scanner)
strong, fixed magnet
resonance radio wave energy at 128 MHz will “resonate with H protons and tilt them away from the main field
radio emitter and receiver
imaging smaller fields are added to across the area to be scanned, which allow a 2D image to be constructed
weak, variable magnets
this imaging method essentially detects the density of ____ in tissue, produces a stack of sharp images in about 15 minutes
structural MRI
this imaging method involves repeated, lower-resolution imaging of the brain, showing interest in image intensity as it CHANGES OVER TIME)
functional MRI (fMRI)
instead of focusing on water concentration, fMRI focuses on the small changes in signal intensity that accompany changes in local ____ oxygenation (BOLD contrast)
blood oxygenation
what does BOLD contrast stand for?
blood oxygen level dependent
high activity states trigger local increases in blood flow and volume (via astrocytes)
the “resupply” exceeds demand by about ____%
30%
this 30% excess of oxygenated blood ____ MRI signal intensity, because oxygenated blood contains slightly ____ iron than deoxygenated blood
increases ; less
how does iron affect magnetic fields?
it perturbs magnetic fields and causes signal intensity to sharply drop
because BOLD tracks the blood flow change, and not the neural activity that triggered it, BOLD signal onset is ____ and lasts for several seconds after scene offset
delayed
fMRI’s biggest weakness:
the typical fMRI sampling rate is far slower than the speed of the brain
true or false: consciousness is defined as correlated activity across at least 75% of the brain
false; there is little agreement about what consciousness is
true or false: consciousness is defined as the electrochemical activity of the brain oscillating above ~15 Hz
false; there is little agreement about what consciousness is
human skull volume has ____ over the last 2 million years
tripled
human skull volume has ____ over the last 5,000 years
a. remained stable
b. increased slightly
c. doubled
d. tripled
a. remained stable
human cortex shows unique structural features, such as:
a. homogeneous tissue organized in columns and layers
b. dense convolutions, including gyri and sulci
c. left-right symmetry in structure
d. all of the above
d. all of the above
true or false: the fissures of the cortex are unique to all individuals
false
true or false: subcortical structures operate independently from the cortex
false