Final Exam Flashcards
Define Physiology
The branch of biology that concentrates on studying the normal function of a living organism and its parts.
What does a fertilized egg do?
Divides, those cells proliferate, differenciate and self assemble
What is the basic unit of the body?
A cell
How many cells do we have?
100 trillion
T/F Cells are specialized
True
What are cells organized into?
Tissues and Organs
What are cells held together by?
extra-cellular structures
What do cells require to live?
Water Oxygen Ions amino Acids Other nutrients
Where do cells obtain their input materials and release their output materials to?
Extra cellular fluid
How much of the human body is essentially water?
60%
How much of the water that makes up the human body is extracellular fluid?
1/3 of 60% water so about 20% of the water is ECF
How much intracellular fluid makes up the fluid in the body?
2/3
How is the volume and composition of the ECF controlled?
Homeostatic mechanisms
What is critical to maintain life in terms of ECF?
The compositon
Define Homeostasis
A state of equlibrium within living organisms characterized by the maintainence of nearly constant internal environmental conditions. All organs and tissues participate.
How many Liters of water in a 70 kg male?
42 Liters ( 60%)
What makes up the extracellular fluid?
Blood Plasma
Intersticial Fluid
Transcellular fluid
How much of the body is intracellular fluid?
60% of the water in the body or 25 liters
What mediates the constant mixing of ECF?
Blood Plasma
How much of the bodies water is in the blood plasma?
7% or 3 L
What is intersticial fluid?
fluid in spaces between cells in tissues (fluid inbetween the plama membrane and capillary endothelium)
What makes up intersticial fluid
Bulk intersticial (61.5%) Bone (7.6 %) Dense CT (23%)
How much of the bodies water is intersticial fluid?
31% (Mostly Bulk intersticial)
What is transcellular fluid?
Fluid in spaces surrounded by epithelia (Joint synvial fluid, CSF)
How much of the bodies water is transcellular fluid?
1 Liter or 2.38%
Why is there a difference in chemical composition of intracellular aand extracellular fluids?
Difference is due to control of transport of these substances accross the plasma membrane.
What do G cells secrete?
Gastrin into the blood stream
What do parietal cells secrete?
HCl and intrinsic factor
What do Mucus Neck cells secrete?
Mucus
What do chief cells secrete?
pepsinogen and gastric lipase
What do Enteroendochrine cells (G cells)
Secrete?
Gastrin
What lines the gastric pit?
Simple columner epithelium with Mucus suface cells
What type of cells are found in the gastric glands?
Parietal, Mucus Neck Chief and G cells
What does Submucosal Plexus control?
Secretion
What type of transport is used for HCl secretion
Active-Protons are pumped out of the cell in exchange for a potassium ion
What enzyme catalyzes the reaction in parietal cells?
Carbonic Anydrase-abundant?
How are chloride ions released into the gastric lumen?
Diffusion
T/F Choloride and Protons are released seperately into the gastric lumen
True!
How is HCl formed in the parietal cell?
Via the Carbonic Anyhydrase which is abundant in the pareietal cells
Where are H+ K+ ATPase located in the pareital cells?
Apical Membrane that faces the lumen
What provides energy for the outward transport of H+
ATPase
What is H+-K+ATPase inhibited by?
Omeprazole
What does omeprazole treat?
Gastric and duodenal ulcers
What provides energy for the active transport of Cl- across the pareital membrane?
The downhill movement of HCO3+
What is the function of HCl?
- Eliminates ingested bacteria
- Facilitates protein digestion
- Provides acidic environment essential for the activation and function of pepsin
What stimulates the secretion of gastric HCl?
Acetylcholine
Histamine
Gastrin
*through several second messenger systems
What inhibits gastric HCI secretion?
Somatostatin
Parasympathetic _____ induces _____ release
Parasympathetic Stimulattion induces ACh release
where are the G cells located?
The Antrum
What does gastrin do?
Stimulates HCl and pepsinogen secretion; and motility
What is released from the enterochrochromaffin like cells?
Histamine
What is the function of histamine?
- Direct stimulation of HCl
- Increase the secretion induced by ACh or gastrin
- It is a paracrine agent
What receptors does Histamine stimulate?
H2 receptors on the pareital Cells
What is the function of Cimetidine?
It inhibits acid secretion by blocking H2 receptors
What is the most important trigger for pepsinogen secretion?
Vagal Stimulation
When is pepsinogen active?
Only in a highly acid environment (1.8-3.5)
What is essential for protein digestion in the stomach?
HCl and Pepsin
What does pepsin do?
Breaks down peptide bonds found in proteins
What does intrinsic factor form a complex with?
Vitamin B-12
Once a complex forms from vitamin B-12 and Intrinsic facor, what does the complex do?
Binds to specific receptors in the ileum and then is absorbed via endocytosis
If someone has undergone abdominal surgery and are intrinsic factor deficient what are they vunerable to?
Iron deficiency anemia so they much eat frequently
What is dumping syndrome?
- develops following removal of part of the stomach
- Anastomosis of the jejunum to the stomach
- Rapid entry of hypertonic meals into intestine
What is the role of mucus in the stomach
Forms a gel like protective barrier butween glandular cells and lumen
Mucus is secreted by ______ and _____ in the ___ and _____ regions of the stomach
Mucus is secreted by Mucus Neck Cells and surface epithelial cells in the body and fundus regions of the stomach.
How often do epithelial cells get replaced?
every 3-6 days
What happens in the cephalic phase of digestive regulation?
- Somatostain inhibits gatrin secretion
2. Vagus nerve inhibits the release of Somatostatin
What kickstarts the cephalic phase?
Sight, smell, or presence of food in the mouth
What mediates the cephalic phase?
Vagus nerves originate in the medulla oblongota
What initiates the cephalic phase secretion?
Stimulation of the enteric neurons by vagal fibers
What directly stimulates the pareital,mucus, and chief cells during the cephalic phase?
the post ganglionic parasympathetic fibers
What do the post ganglioic parasympathetic indirectly stimulate during the cephalic phase?
G cells by inducing gastrin
What are the primary stimuli of the gastric phase?
Distention of the stomach
Gradual increase in the pH of gastric contents
Presence of protein breakdown products
What senses elevated pH during the gastric phase?
Chemoreceptors
What senses distention of the stomach during the gastric phase?
Stretch Receptors
Wat do the stretch receptors and chemoreceptors send the signal to?
Submucosal and Myenteric Plexuses
What occurs during the intestinal phase?
Enterogastric reflex
What elicits the intestinal phase?
Entry of acidic chyme into the duodenum
what is the purpose of the intestinal phase?
Control the rate of gastric emptying (enterogastric reflex)
What happens during the enterogastric reflex?
The duodenum sends inhibitory signals to the stomach by way of both the nervous and hormonal reflexes
what is acid, pepsin secretion and gastric motility inhibited by in the intestinal phase?
the presence of
fat, carbs, acid, etc. in the duodenum
What triggers the enterogastric reflex?
Distention of the stomach
What type of secretions are secreted during the intestinal phase for protection?
Mucus- from acid and enzymes
What inhibits gastric secretions in the stomach?
Duodenal secretion
CCK
GIP
Stomach emptying is ________ by the _____ _______,_______ and _____ in the duodenum.
Stomach emptying is inhibited by the enterogastric reflex, enterogastrones and fat in the duodenum.
What regulates gastric emptying?
Hormonal and Neuronal Reflexes
What do duodenal entero-endocrine cells secrete in the presence of fatty, hypertonic, acidic chyme in the duodenum?
Enterogastrones (CCK, Secretin, VIP)
What happens when enterogastrones (Hormones) such as Secretin, CCK and VIP are secreted?
Contractile force and rate of stomach emptying decline
What do chemoreceptors and stretch receptors target in the presence of fatty, hypertonic and acidic chyme in the duodenum?
Enteric neurons via short reflexes and CNS centers(SNS activity(kickstarted) and parasympathetic activity) via long reflexes
As a result of enterogastrone secretion, enteric neuron stimulation and CNS stimulation what happens in terms of the intestinal phase?
Contractile force and rate of gastric emptying decline
What activates the cephalic phase?
prior to food entry
What activates the gastric phase?
Food Enters the Stomach
What activates the intestinal phase?
Partially digested food enters the duodenum