Final Exam Flashcards
Examples of neurodevelopmental disorders
ADHD, autism, ID, cerebral palsy
Environmental causes of neurodevelopmental disorders
Prenatal alcohol, hypoxic brain injury, lead toxicity
Genetic causes of neurodevelopmental disorders
Metabolic PKU, trisomy 21, fragile X
Impaired social communication, repetitive and stereotyped behavior, interests and activities
Autism
Geriatrics
<60
Goal in geriatric care
optimize function
What to assess in geriatric
Function, gait, cognition, fall risk, polypharmacy, social support, finances, advanced care planning
5 I’s of geriatric assessment
intellectual impairment, iatrogenic disorders, incontinence, immobility, instability
Mini cog exam
3 item recall + clock
If you get all 3 items correct, you do not need to do the clock drawing
2 question screen
for depression
BEERS criteria
Anticholinergics, antihistamines, benzodiazepines, muscle relaxants, antihistamines, nitrofurantoin, alpha 1 blockers, TCAs, 1st gen antipsychotics
Most common incontinence
Urge
BPH type of incontinence
Overflow
Treat with alpha blockers
Neuro incontinence
Urge
Treat with anticholinergics
Decreased musculature incontinence
Stress
treat with kegals
Normal sleep cycle for geriatrics
3-5 hours
Osteoporosis
> 2.5 SD below mean on DEXA scan
Due to decreased estrogen, calcium and vitamin D, exercise, and increased alcohol
Sarcopenia
Decreased muscle mass
Presbyopia
Decreased near vision due to stiffness of lens
Need reading glasses
Presbycusis
Decreased hearing, especially high pitched sounds
Frailness
Decreased weight, weakness, slow walking speed, exhaustion, decreased activity
Xerostemia
Dry mouth
Treat with pilocarpine or cevimeline
Dysphagia
Difficulty swallowing
Pharmacokinetics
Absorption, distribution, metabolism, elimination
Zinc, calcium, iron, multivitamins alter absorption
Pharmacodynamics
How the body responds to drugs
Decreased baroreceptor response in elderly and increased sensitivity to anticholinergics
Aim of palliative care
Improve quality of life
nociceptive pain
Localized, sharp or throbbing or aching
Use NSAIDs, acetaminophen, opioids
Neuropathic pain
Burning
Use amitriptyline, neurontin, lidocain patch, capsaicin
Avoid what opioids in renal failure
Morphine
What opioids are safest for renal failure
Fentanyl and methadone
Treatment of dyspnea in palliative care
Morphine
Metabolic syndrome
High fasting blood sugar, high BP, High triglycerides, truncal obesity, low HDL, xanthomas
Diagnostic for insulin resistance
gold standard is euglycemic insulin clamp technique or fasting plasma insulin concentration (increased plasma insulin and normal glucose=insulin resistance)
Where is cholesterol synthesized
in the liver
Medications that may cause elevated cholesterol and lipids
Amiodarone, steroids, cyclosporine, beta blockers
When should you repeat lipid panel
4-12 weeks after initiating lipid lowering therapy
Goals/high values for cholesterol
Total: goal <200, 200-239 borderline, >240 high
LDL: Goal <100, 100-129 above normal, 130-160 borderline high, >160 high
HDL: Goal >60 for cardioprotective, <40 major risk
Triglycerides: Goal <150, >500 high, >1000 risk of pancreatitis
SE statins
myopathy (check CK levels), hepatic inflammation (check LFT)
When to take statins
bedtime
Target groups for statins
> 190 LDL
DM and LDL 70-189 and age 40-75
CVD disease
ASCVD risk >7.5%
Xanthelasma
Yellow fatty deposits on eyelids
Xanthomas
Fatty deposits on elbows, knees, joints
Secondary hypertension due to
Renal stenosis, pheochromocytoma, coarctation of aorta, cushing disease, thyroid disease, alcohol, OCP, steroids
Consider secondary htn if age
<30 or >65
Goals of BP
<60 age <140/90
>60 age <150/90
DM regardless of age <140/90
If BP goal not reached within 1 month
Increase dose or add another med
Masked HTN
Normal in office but high out of office
Symptoms of end organ damage in htn
blindness, loss of visual acuity, headaches, confusion, seizures, impotence, claudication, chest pain, dyspnea, palpitations, syncope, hematuria, dysuria, oliguria
monitor what after starting ACEI/ARB or diuretic
K+ and renal function
Risk factors for PAD
HTN, DM, increased lipids, tobacco use
Symptoms of PAD
poor wound healing, claudication, dependent rubor, loss of hair on extremities
Dx for PAD
ABI <0.9, US, Angiogram
PE for PAD
Pain, pulseless, paresthesia, pallor
Tx PAD
aspirin, statin, BP control, DM control, compression stockings, decrease smoking
HF with reduced EF
Systolic HF–LV
HF with normal EF
Diastolic HF–RV
Sx/PE of HF
Dyspnea, fatigue, edema, JVD
S3 heart sound, crackles, hepatomegaly, displaced PMI, cardiac enlargement
Gold standard for diagnosing HF
Echo
Strongest marker for HF prediction
BNP
Chest X ray can show what in HF
Cardiac enlargement
Daily weights in HF
Call if >2ib in 1 day or 5ib in 1 week
Tx of HF
Beta blocker, ACEI/ARB, loop diuretic, spirinolactone
What meds should you avoid in HF
NSAIDs, and CCB
Beta blockers recommended for HF
Carvedilol, metoprolol, bisoprolol
S1 and S2
S1: closure of AV valves
S2: closure of SL valves
Systolic murmurs
Aortic stenosis Pulmonary stenosis Tricuspid regurg Mitral regurg MVP
Diastolic murmurs
Aortic regurg
Pulmonary regurg
Tricuspid stenosis
Mitral stenosis
Harsh crescendo-de-crescendo murmur
AS
Midsystolic click
MVP
MVP tx
beta blockers, ACEI
Most important goal in A fib control
Ventricular rate control
1st degree AV block
Prolonged PR interval but always has a QRS
2nd degree AV block type 1
Prolonged PR interval increasing until QRS dropped
2nd degree AV block type 2
Prolonged or normal PR interval and random QRS drop
3rd degree AV block
No relationship between PR and QRS
Adduction
movement towards midline of body
Abduction
Movement away from midline of body
Most common malignant tumor of bone
multiple myeloma
Labs in multiple myeloma
Increased alkaline phosphatase, bence jones proteins, M spike, Increased CRP and ESR
Pain management in bone tumors
Vertebroplast, radiation, biphosphonates
Shoulder injuries hurt more often when
Arm is elevated
Radiculopathy feel better when
Arm elevated
Tests for shoulder
Apprehension, empty can, drop arm, impingement, Hawkin, NEER
Adhesive capsulitis
Shoulder immobilization or gradual onset of shoulder pain
Medial epicondylitis
Golfers elbow
Lateral epicondylitis
Tennis elbow
ROM testing for elbow
Flexion, extension, suppination, pronation
Treatment of fibromyalgia
Amitriptyline, SSRI, cyclobenzaprine
Dx for fibromyalgia
> 7 tender points for >3 months
Symmetric wrist/hand pain
Think RA, SLE or malignancy
Tests for capal tunnel
Phalen
Tinnel–push on median nerve
Most common cause of secondary osteoporosis
Steroids
DEXA scan recommended
Women >65 and men >70
Recommendations for Ca and Vit D
Ca 1000-1200mg daily
Vit D 800-1000 daily
Medications for osteoporosis
Biphosphonates, denosumab, calcitonin, taloxifene
Education for biphosphanates
Do not lie down for 30 minutes-60 minutes after
CI in esophageal dysmotility
Master controller
Hypothalamus
Anterior pituitary hormones
FLAT PEG
FSH, LH, ACTH, TSH, Prolactin, Endoprhins, growth hormones
Posterior pituitary hormones
Oxytocin, ADH
Begin DM screening
Age 45
Dx for diabertes
Random BG >200
Fasting BG >126
A1C >6.5
Dx for pre-diabetes
Random BG 140-199
Fasting BG 100-125
A1C 5.7-6.4
Somogyi effect
Rebound hyperglycemic in the morning due to hypoglycemic in the middle of the night–give less night time insulin
Dawn phenomenon
High hyperglycemia in the morning due to growth hormones released at night–increase night time insulin dose
Rapid acting insulin
Lispro, aspart, glusiline
long acting insulin
Detemir, glargine
Microvascular complications of DM
Retinopathy, neuropathy, nephropathy
Macrovascular complications of DM
CAD, PVD, stroke
Secondary causes of DM
Pheochromocystoma, cushing, acromegaly, hypokalemia, hyperaldosterone, diuretic use, pancreatitis, drug induced
DKA S/S
Abdominal pain, N/V, Kussmaul respirations, dehydrated, fruity breath, tachycardia, hypotension, decreased LOC
C-peptide
<0.5 Type 1 DM
>0.5 Type 2 DM
ADA A1C goal
<7
<8 in elderly
<6 in type 1 and pregnancy
Biguanides
Metformin
Site of action: liver–decrease gluconeogenesis
SE: N/V
NO hypoglycemia
CI in Cr >1.4
Can cause fatal lactic acidosis
D/C 24-48 hours before surgical procedure
Sulfonylureas
Glipizide
Site of action: pancreas–increase insulin secretion
SE: weight gain, hypoglycemia
Thiazolidinediones
Rosiglitazone
Site of action: muscle–increase insulin sensitivity
SE: weight gain and edema
CI in HF + liver disease
Hypoglycemia
BG <70
S/S: shaking, sweating, tachycardia, weak, pallor, decreased LOC
Secondary causes of obesity
cushing, PCOS, hypothyroid, insulinoma
Medications that can cause obesity
Steroids, TCA, phenothiazines
Tx obesity
Phentermine, amphetamines, orlistat
Most common cause of hyperthyroidism
Graves disease
Tx of hyperthyroidism
PTU, Methimazole, beta blockers
hyperthyroidism tx in pregnancy
PTU first trimester, methimazole second and third trimester
SE of PTU/methimazole
rash, jaundice, arthralgia
Tx of choice of hyperthyroid if >20 years
Radioiodine therapy
Norma TSH
0.5-5.5
Normal T4 total
4.6-12
Normal T4 free
0.7-1.9
Normal T3
80-180
Medications that can increase T4
Amiodarone, amphetamines, synthroid
Most common cause of hypothyroidism
Chronic autoimmune thyroiditis
Myxedema
Skin thickening and CV/Renal issues due to hypothyroidism
Tx hypothyroidism
Levothyroxine start 50mcg/day
Do labs in 4-6 weeks and then assess dosage
Education for levothyroxine
Take 1 hour before breakfast and 2 hours before/4 hours after antacids, ferrous sulfate, carafate
Drugs that can decrease thyroid
lithium, interferon alfa, tyrosine kinase inhibitors
Tx of vertigo
Meclizine, diamox, antiemetics
Vertigo vs dizzy
Vertigo: room is spinning
Dizzy: you are spinning
Hallpike-dix
Dx fo BPPV
Paresthesia
Numbness and tingling
Paresis
weakness
First line tx of seizures
Levetiracetam (Keppra)
Check serum levels 2-3x in first 6 months and then every 6 months or if dose changes
S/S PD
Resting tremor, bradykinesia, shuffling gait, rigidity
PD due to
Decreased dopamine
Tx of PD
Levodopa-carbidoba first line
Others: selegiline, bromocriptine, ropinirole, pramipexole, entacapone, trihexyphenidyl, benzotropine, amantadine
Aborptive headache meds
Acetaminophen, aspirine, excedrine FIRST LINE
ergo derivatives, triptans
Caution with ____ when using triptans
CV disease
Preventive tx of headaches
Beta blockers, anticonvulsants, CCB, TCA
First line preventive tx of cluster headache
verapamil or lithium
Most common bacteria for meningitis for adults
Strep pneumoniae
Brudzinski sign
Patient actively flexes hips when neck is passively flexed
Kernig sign
Resists passive knee extension when hip flexed to abdomen
Bacterial meningitis LP
Decreased glucose
Viral meningitis LP
Increased or normal glucose
Tx fo bacterial meningitis
Vancomycin + ceftriaxone
Meningitis vaccine
11-18 years old
If vaccinated between 2-6 years old, should be re-vaccinated again after 3 years
If vaccinated <7 years old, should be re-vaccinated after 5 years
Pneumococcal vaccine
> 65 one time dose
HIB vaccine
2,4,6, 12-15 months
Sleeping sickness
Encephalitis
Usually due to virus
Tx of encephalitis
Antiviral + seizure control
Rash of herpes zoster
Papular lesions with vesicles
Dx for herpes zoster
tzank smear
Tx of herpes zoster
Acyclovir within 72 hours, capsaicin cream, amitriptyline or neurontin
Vaccines for shingles
Zostavax: live
Shingrix: non live
only vaccinate 2-3 weeks after attack
Trigeminal neuralgia
CN5
Tic douloureux
Recurrent pain on one side of face–burning, sharp, penetrating, stabbing
Tx of trigeminal neuralgia
Anticonvulsants–carbamazepine + oxcarbazepine first line
All are sedating
Must monitor lab values
Bell’s palsy
CN 7
Acute and progressive onset
PE: flattening of nasolabrial fold; unable to raise eyebrow or wrinkle forehead, asymmetric smile
Tx for bell’s palsy
Steroids (prednisone high dose then taper) + acyclovir + artificial tears
Eye protection important
Basal skull fracture signs
Raccoon sign + battle sign
Heat stroke s/s
Red, hot, dry skin
Heat exhaustion s/s
Skin pale and flushed