Final Exam Flashcards
Examples of neurodevelopmental disorders
ADHD, autism, ID, cerebral palsy
Environmental causes of neurodevelopmental disorders
Prenatal alcohol, hypoxic brain injury, lead toxicity
Genetic causes of neurodevelopmental disorders
Metabolic PKU, trisomy 21, fragile X
Impaired social communication, repetitive and stereotyped behavior, interests and activities
Autism
Geriatrics
<60
Goal in geriatric care
optimize function
What to assess in geriatric
Function, gait, cognition, fall risk, polypharmacy, social support, finances, advanced care planning
5 I’s of geriatric assessment
intellectual impairment, iatrogenic disorders, incontinence, immobility, instability
Mini cog exam
3 item recall + clock
If you get all 3 items correct, you do not need to do the clock drawing
2 question screen
for depression
BEERS criteria
Anticholinergics, antihistamines, benzodiazepines, muscle relaxants, antihistamines, nitrofurantoin, alpha 1 blockers, TCAs, 1st gen antipsychotics
Most common incontinence
Urge
BPH type of incontinence
Overflow
Treat with alpha blockers
Neuro incontinence
Urge
Treat with anticholinergics
Decreased musculature incontinence
Stress
treat with kegals
Normal sleep cycle for geriatrics
3-5 hours
Osteoporosis
> 2.5 SD below mean on DEXA scan
Due to decreased estrogen, calcium and vitamin D, exercise, and increased alcohol
Sarcopenia
Decreased muscle mass
Presbyopia
Decreased near vision due to stiffness of lens
Need reading glasses
Presbycusis
Decreased hearing, especially high pitched sounds
Frailness
Decreased weight, weakness, slow walking speed, exhaustion, decreased activity
Xerostemia
Dry mouth
Treat with pilocarpine or cevimeline
Dysphagia
Difficulty swallowing
Pharmacokinetics
Absorption, distribution, metabolism, elimination
Zinc, calcium, iron, multivitamins alter absorption
Pharmacodynamics
How the body responds to drugs
Decreased baroreceptor response in elderly and increased sensitivity to anticholinergics
Aim of palliative care
Improve quality of life
nociceptive pain
Localized, sharp or throbbing or aching
Use NSAIDs, acetaminophen, opioids
Neuropathic pain
Burning
Use amitriptyline, neurontin, lidocain patch, capsaicin
Avoid what opioids in renal failure
Morphine
What opioids are safest for renal failure
Fentanyl and methadone
Treatment of dyspnea in palliative care
Morphine
Metabolic syndrome
High fasting blood sugar, high BP, High triglycerides, truncal obesity, low HDL, xanthomas
Diagnostic for insulin resistance
gold standard is euglycemic insulin clamp technique or fasting plasma insulin concentration (increased plasma insulin and normal glucose=insulin resistance)
Where is cholesterol synthesized
in the liver
Medications that may cause elevated cholesterol and lipids
Amiodarone, steroids, cyclosporine, beta blockers
When should you repeat lipid panel
4-12 weeks after initiating lipid lowering therapy
Goals/high values for cholesterol
Total: goal <200, 200-239 borderline, >240 high
LDL: Goal <100, 100-129 above normal, 130-160 borderline high, >160 high
HDL: Goal >60 for cardioprotective, <40 major risk
Triglycerides: Goal <150, >500 high, >1000 risk of pancreatitis
SE statins
myopathy (check CK levels), hepatic inflammation (check LFT)
When to take statins
bedtime
Target groups for statins
> 190 LDL
DM and LDL 70-189 and age 40-75
CVD disease
ASCVD risk >7.5%
Xanthelasma
Yellow fatty deposits on eyelids
Xanthomas
Fatty deposits on elbows, knees, joints
Secondary hypertension due to
Renal stenosis, pheochromocytoma, coarctation of aorta, cushing disease, thyroid disease, alcohol, OCP, steroids
Consider secondary htn if age
<30 or >65
Goals of BP
<60 age <140/90
>60 age <150/90
DM regardless of age <140/90
If BP goal not reached within 1 month
Increase dose or add another med
Masked HTN
Normal in office but high out of office
Symptoms of end organ damage in htn
blindness, loss of visual acuity, headaches, confusion, seizures, impotence, claudication, chest pain, dyspnea, palpitations, syncope, hematuria, dysuria, oliguria
monitor what after starting ACEI/ARB or diuretic
K+ and renal function
Risk factors for PAD
HTN, DM, increased lipids, tobacco use
Symptoms of PAD
poor wound healing, claudication, dependent rubor, loss of hair on extremities
Dx for PAD
ABI <0.9, US, Angiogram
PE for PAD
Pain, pulseless, paresthesia, pallor
Tx PAD
aspirin, statin, BP control, DM control, compression stockings, decrease smoking
HF with reduced EF
Systolic HF–LV
HF with normal EF
Diastolic HF–RV
Sx/PE of HF
Dyspnea, fatigue, edema, JVD
S3 heart sound, crackles, hepatomegaly, displaced PMI, cardiac enlargement
Gold standard for diagnosing HF
Echo
Strongest marker for HF prediction
BNP
Chest X ray can show what in HF
Cardiac enlargement
Daily weights in HF
Call if >2ib in 1 day or 5ib in 1 week
Tx of HF
Beta blocker, ACEI/ARB, loop diuretic, spirinolactone
What meds should you avoid in HF
NSAIDs, and CCB
Beta blockers recommended for HF
Carvedilol, metoprolol, bisoprolol
S1 and S2
S1: closure of AV valves
S2: closure of SL valves
Systolic murmurs
Aortic stenosis Pulmonary stenosis Tricuspid regurg Mitral regurg MVP
Diastolic murmurs
Aortic regurg
Pulmonary regurg
Tricuspid stenosis
Mitral stenosis