FINAL EXAM Flashcards
what is the pH of commercial lidocaine?
3.9
why is the pH of amide local anesthetic acidic compared to the tissue pH?
this enhances the solubility of the anesthetic salts to prolong the shelf life
what are the two forms of the anesthetic salt?
- the uncharged, de-ionized or ACTIVE free base form- lipid soluble
- the charged or ionized cationic form which is not lipid soluble.
what form of the anesthetic salt is important in penetrating into the nerve membrane?
the DEIONIZED form-because its lipid soluble and can more readily penetrate the nerve membrane to enter nerve axon.
how much lidocaine does a 1.7 ml carpule of 2% lidocaine 1:100K epi have and how much epi?
34 mg lid and .017 mg epi
if you have 3% lido how many mg?
3%=30 mg/ml * 1.7 ml/carpule = 51 mg. easy
what is the max dose of EPI you should memorize???
4.4 mg/kg
(although you should still take into account rate of absorption, patient health status, tissue conditions, age considerations, etc.)
where is the mandibular foramen in a child relative to an adult?
in a child, it is slightly below the plane of occlusion
if the patient has an infection, what can you do to
give preoperative ibuprofen, 1 hour before the local anesthesia injection.
what is the risk of anesthesia and opioids?
higher risk of epi toxicity
describe symptoms of anesthesia overdose?
- CNS excitation
- CNS depression
- CVS excitation
- Cardiac arrest
this occurs when iron in hemoglobin is changed from its ferrous to its ferric form
methemoglobinemia.
CANNOT ACCEPT oxygen to carry to tissues
methemoglobin concentration greater than ___ of total hemoglobin can cause cyanosis
10-15%
what is it in the local anesthetic that can cause methemoglobinemia?
the nitrates and aniline derivitaves which are part of all local anesthetics
what its the major cause of deaths due to local anesthetic administration?
overdose
what is the purpose of sodium bisulfite?
added with vasoconstrictors to increase the shelf life.
so if patient has allergies/sensitivites, should NOT recieve anesthetic with a vasoconstrictor
what part of the topical anesthetic may cause an allergic reaction?
PABA- the metabolite that’s used
where are amides metabolized? except which one?
in the liver!
PRIOLCAINE is expcetion- it’s in the kidney and plasma
What if your patient has atypical pseudocholinesterase…what should you be aware of?
esters! topical anesthetic
what is the purpose of the buffer?
increases the pH and produces more DEIONIZED fom of anesthetic to cross the lipid barrier.
Sodium bicarbonate is used as the buffer
*patients physiology is generally the buffer???**
canines emerge when __ of the root if formed.
3/4
premolars emerge when __ - ___ of the root if formed?
1/2-3/4
for each mm of alveolar bone overlying a succedaneous tooth, approx ___ months of eruption should be anticipated
6 months
most space loss occurs within the first __ - __ months?
4-6 months