FINAL DRUGS MEMORIZE

Question 1

What are Nonbiologic DMARDs used for? Name 2

Answer 1

rheumatoid arthritis

Methotrexate, sulfasalazine

Question 2

What are Biologic DMARDs used for? Name the example drug

Answer 2

Rheumatoid arthritis

Tumor Necrosis Factor (TNF) inhibitors

Question 3

Describe the significance, indication, and adverse effects of:

Methotrexate

Answer 3

Methotrexate → most rapid acting, 3-6 weeks = first line of therapy
○ Indications for use: severe and active rheumatoid arthritis (ACR)
○ Adverse effects: hepatic fibrosis, bone marrow suppression, GI ulceration, and pneumonitis

Nonbiologic DMARDs:

Question 4

Describe the significance, indication, and adverse effects of:

Sulfasalazine

Answer 4

Sulfasalazine → pts who cannot tolerate other medication (ex: salicylates or NSAIDs)
○ Indications for use: RA
○ Mechanism of Action: anti-inflammatory and immunomodulatory actions
○ Adverse effects: GI side effects may be intolerable

Nonbiologic DMARDs:

Question 5

Describe the significance, indication, and adverse effects of:

Tumor Necrosis Factor (TNF) inhibitors

Answer 5

Tumor Necrosis Factor (TNF) inhibitors
○ Indications for use: RA
○ Mechanism of Action: suppress immune function; work on neutralizing TNF
● Immune/inflammatory response initiated by:

Cytokines → break down bone → inflammation of the synovial fluid
○ Adverse effects: pose risk of serious infection

Biologic DMARDs