Final: Anti-VEGF

Question 1

What isoforms of VEGF-A does Lucentis inhibit? What is it FDA-approved for? Is it expesive or cheap?

Answer 1

Inhibits all isoforms
FDA approved for DME, wet ARMD, Macular edema
Very expensive, $2000 per injection

Question 2

What isoforms of VEGF-A does Avastin inhibit? What is it FDA-approved for? Is it expensive or cheap?

Answer 2

Inhibits all isoforms
Was created for cancer so FDA approved for colorectal cancer but used off-label for wet ARMD, DME, and RVO.
CHEAP! $50 dollars per injection

Question 3

True or false:
Outcomes between Avastin and Lucentis are about the same.

Answer 3

True

Question 4

What isoforms of VEGF-A does Eylea inhibit? What is it FDA-approved for? What is it also known as? Is it expensive?

Answer 4

Inhibits all isoforms
FDA approved for Wet ARMD, DME, RVO
Yes, most expensive

Question 5

What anti-VEGF also blocks placental growth factor and has higher affinity for VEGF?

Answer 5

Eylea

Question 6

True or false: Eylea has a longer half life than Lucentis or Avastin so we can inject it every two months instead of monthly

Answer 6

True

Question 7

What drug is Beovu similar to?

Answer 7

Eylea, but it has more side effects and isn’t as popular

Question 8

What drug is approved for geographic atrophy?

Answer 8

Syfovre
Intravitreal complement inhibitor
Decreased geographic atrophy by 25%
But has increased risk for CNV formation (Wet ARMD)