Final Flashcards
Hallucinogens
Substances that alter sensory processing in the brain, causing perceptual disturbances, changes in thought processing, depersonalization
Psychotomimetic (mimics)
Substances that cause psychotic-like symptoms.
Psychedelic (deliberates)
Substances that expand/heighten perception and consciousness.
Psychotogenic (generates)
Substances that initiate psychotic behavior.
5HT Hallucinogens (Also called tryptamine derivatives)
LSD
Psilocybin (or Teonanacatl)
Other Natural Sources
Lysergic Acid Diethylamide (LSD) Creator
Synthesized in 1938 by a chemist (Albert Hoffman) working for Sandoz Laboratories in Switzerland, but is derived from the ergot fungus
LSD potency
It is the most potent hallucinogen known (dosages are measured in micrograms).
-100x more potent than psilocybin -4,000x more potent than mescaline.
5HT: Psilocybin
Mushrooms of genus psilocybe, conocybe, panaeolus, stropharia (also baeocyctis, semilanceata, and stunzii).
-Grow throughout the world.
Natural Sources of 5HT
Iboga plant from Africa.
Virola tree
Morning glory seeds
Bufotenine - Toad Smoking
Toad Smoking
The skin and poison of Bufo alvarius
Venom is taken from parotid then dried and smoked. The high lasts about 20m. The user is usually unresponsive for 5m or more, making little noises until they open their eyes.
5HT Sensory and Psychological Effects
Users may experience some or all of the following stages during a typical trip.
1. Heightened, exaggerated senses.
Synethesia is common.
2. Loss of control.
3. Self-reflection.
4. Loss of identity and a sense of cosmic merging.
5HT Visual Effects
May Include: Walls breathing Tracers Moving colored geometric patterns (especially with closed eyes) Intensification of colors and brightness (sparkling) New textures on objects Blurred vision Shape suggestibility
Guidelines for Dealing with a Bad Trip
- Stay calm with the person.
- Reassure the person that the situation is temporary & that you will not leave until s/he returns to normal.
- Encourage deep, calm breathing.
- Advise person to view trip as though watching a movie.
- Reduce loud noises & bright lights, but avoid darkness because it encourages hallucinations.
- You can divert attention from panic by encouraging enjoyment of music/art collections.
- If you cannot get the situation under control within a reasonable time, seek medical attention. Bad trips can be treated with minor/major tranquilizers.
NE Hallucinogens (or phenylethylamine derivatives): Nutmeg
Contains Myristicin
-hallucinogenic at 2 tbsp
Recreational properties take ≈ 4 hrs to take effect.
May cause severe tiredness, prolonged sleep and dehydration.
Effects can last for days.
NE Hallucinogen Characteristics
- Synthesized from common chemicals in backroom laboratories.
- Was initially exempt from control by the DEA.
- Skillfully marketed with exotic names.
- Most common is Ecstasy. Produces a sensation of being closer to people, with enhanced empathy.
NE Hallucinogen Types
MDMA- (Ecstasy, XTC, Adam)
MDA- (Love Drug)
MDE- (Eve)
DOM- (STP (Serenity, Tranquility, & Peace))
NE Hallucinogen Concerns
‘backyard’ chemists, quality control is poor.
“dance drug”, stimulates the nervous system, it energizes the muscles and allows for continuous movement. It also increases BP and temperature.
Occasional deaths result from effect on the body’s thermoregulatory system (i.e., overheating).
There are also some concerns about long term effects on the brain.
ACh Hallucinogens
Plant substances that block ACh receptors in CNS/PNS.
Causes delirium, clouding of consciousness, disrupted memory, and then sleep as well as dilated pupils, dry mouth, racing heart, excitement, a sensation of lightness and/or flight, frenzied dancing, dreamy visions.
Used in past as beautifiers, love potions, poisons, and in witchcraft/black mass.
Most come from the potato family.
ACh Hallucinogens: Deadly Nightshade Plant
Contains atropine.
14 berries will kill.
Used for centuries by assassins.
Species name means “beautiful woman” because of pupil dilation effect.
Anesthetic Hallucinogens Types
Ketamine
Phencyclidine (PCP)
Ketamine
Brand name Ketalar; slang Special K.
Used as an anesthetic in Vietnam. Currently a veterinary anesthetic.
Can cause a sensation of floating, dissociation, stimulation/hallucinations.
Phencyclidine 1: PCP
Brand name Sernyl or Sernylan. Slang; Angel Dust, Killer Weed, Embalming Fluid, and Rocket Fuel.
When pure, it is a white crystalline powder. Impure- tan to brown, consistency from powder to a gummy mass.
Sold in tablets, capsules, powder or liquid form, applied to a leafy material, such as parsley, mint, oregano or marijuana, and smoked
PCP History
In 1950s, it was investigated as an anesthetic but, due to the side effects, development for human use was discontinued. It became available for veterinary use in the 1960s.
PCP Effects
Causes stimulation, a sensation of floating, a sense of incredible strength and mental distortions. User feels “like a rubber doll.”
PCP : Low Dose (>5mg)
Agitation Serious incoordination Blank stare, catatonic rigidity Unable to speak Lessened response to pinprick Flushed, profuse sweating Sensitive to sound Nystagmus
PCP: Moderate Dose (5 - 10 mg)
Coma or stupor. Eyes remain open, pupils in middle & reactive. Extreme salivation, vomiting. Repetitive motor movements. Flushed, shivering, profuse sweating. Nystagmus. Fever. Insensitive to pain, touch.
PCP: High Dose (> 10 mg)
Long coma (12 hours to days). Eyes closed. High BP. Muscular rigidity, convulsions. No peripheral sensation. Profuse sweating. Decreased corneal & gag reflexes. Hypersalivation. Fever. Repetitive motor movements. Posture may be bowed (abdomen out).
Salvia Divinorum
Powerful psychoactive plant.
Typically chewed or smoked, it produces experiences ranging from laughter to intense hallucinations.
The duration of effects is brief (mins).
Became illegal in WI due to the 2009 WI Act 141.
Active psychoactive constituent is a structurally unique κ-opioid receptor agonist.
Common reported aftereffects include improved mood, sensations of insight, calmness, connection with nature. However, it may cause dysphoria and STM loss.
It has low toxicity and low addictive potential, may have potential as an analgesic and therapeutic tool for treating drug addictions.
Marijuana: HS Senior Use (1975-05)
High point in late 70s
Low point in early 90s
Currently ≈35%
Marijuana Forms
Most ordinary marijuana: 3% THC. Sinsemilla: 7.5% THC (up to 24%). Hashish: 3.6% (up to 28%). Hash oil: 16% (up to 43%). Cannabis Extract was used historically. K2/Spice