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Immunology > Final > Flashcards

Final Flashcards

1
Q

Hypersensitivty mediated by IgE

A

Type 1

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2
Q

Type 3 hypersensitivity is best described by

A

requires immune complex formation

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3
Q

All are true about erythroblastosis fetalis except

A

most severe during 1st pregnancy

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4
Q

X linked primary congenital humoral immunodeficiency

A

Bruton’s

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5
Q

Death in a case of systemic anaphylaxis usually due to..

A

asphyxiation

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6
Q

Natural Suppression can be explained by..

A

clonal deletion theory
clonal anergy theory
suppression

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7
Q

T/F Tolerogens activate lymphocytes

A

T

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8
Q

Blood transfusion rxn is what type?

A

II

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9
Q

T/F Products of MHC mainly regulate transplantation, immune responsiveness, and aspects of complement synthesis

A

True

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10
Q

Graft versus host disease occurs because of ___________ in the graft tissue.

A

T cells

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11
Q

An Arthus reaction is characteristic of which type of hypersensitivity reaction?

A

III

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12
Q

Increased susceptibility to fungal, viral and protozoan infections is associated with

A

T cell deficiencies

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13
Q

In this mechanism of suppression the body makes antibodies against its own antibodies.

A

Production of anti idiotype antibodies

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14
Q

This theory to explain natural tolerance holds that cells with high affinity for self antigens are destroyed in the primary lymphoid organs.

A

Clonal deletion

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15
Q

Which of the following is a graft between genetically different members of the same species.

A

Allograft

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16
Q

Graft versus host reaction frequently develops following transplantation of

A

bone marrow

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17
Q

Tolerance to endogenous antigens is

A

natural tolerance

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18
Q

Which type of hypersensitivity is due to the presence of IgE?

A

I

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19
Q

Which type of hypersensitivity is due to T cell reactivity?

A

IV

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20
Q

The most common immunodeficiency disorder is

A

Selective IgA deficiency

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21
Q

ediak-Higashi Syndrome is characterized by

A

problem with phagocytosis

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22
Q

In this congenital disease the lymphocytes lack MHC markers

A

bare lymphocyte syndrome

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23
Q

Serum sickness from the administration of horse immunoglobulin results in
a systemic ____________ hypersensitivity reaction.

A

Type III

24
Q

Mechanism/s for cell damage in type II hypersensitivity

A

Classical complement cascade
natural killer cells
opsonization

25
Q

Incompatible blood transfusion could induce a hemolytic reaction that results in intravascular lysis of the RBC’s, and release of ————from lysed cells.

A

Hemoglobin

26
Q
  1. The lack of immune response for self-antigens in the tissue is caused by:
    a. Deletion of self reactive cells
    b. Inactivating the cell (anergy)
    c. Optimization
    d. A and B
A

D

27
Q

This tolerance is unresponsive to self-antigens ( all the endogenous antigens).

a. Natural tolerance
b. Active tolerance
c. Acquired tolerance
d. Autoimmune disease

A

A

28
Q

Function of T suppressors cells is important in suppression.

a. True
b. False

A

A

29
Q

In Graves’ disease, antibodies blood, the TSH ( thyroid stimulating hormone) receptors on the thyroid gland.

a. True
b. False

A

A

30
Q

Which of the following autoimmune disease is associated with butterfly rash on the face?

a. Diabetes mellitus
b. Graves’ disease
c. Myasthenia gravis
d. Systemic lupus ( SLE, Red Wolf)

A

D

31
Q

Which of the following factors is/are involved in insulin dependent diabetes mellitus autoimmune disease?

a. Infection
b. HLA gene
c. A and B
d. None of the above

A

C

32
Q

Which one of the following biochemical/s is/are going to be reduce in Hashimoto’s thyroiditis?

a. Interferon
b. Insulin
c. Thyroxin
d. All of the above

A

C

33
Q

Which of the following is called rheumatoid factor?

a. IgE-antibody against F-ab portion of a patient’s own IgG
b. IgM-antibody against F-ab portion of a patient’s own IgG
c. IgM-antibody against F-c portion of a patient’s own IgG
d. IgG-antibody against F-c portion of a patient’s own IgM

A

C

34
Q

Multiple sclerosis is associated with which of the following types of hypersensitivity reactions?

a. I
b. II
c. III
d. IV and III

A

D

35
Q

The antibodies in warm agglutinin type immune hemolytic anemia consist of which of the following classes of immunoglobulins?

a. IgG
b. IgM
c. IgE
d. IgA

A

A

36
Q
  1. Allografts of lymphoid tissue are particularly immunogenic because of the high content of
    a. MHC class II expressing cells
    b. MHC class III expressing cells
    c. MHC class I expressing cells
    d. A and B
A

A

37
Q
  1. An example of a type III immune complex disease is
    a. Rheumatoid Arthritis (RA) (SLE) and scleroderma
    b. Contact dermatitis
    c. Graft rejection (host versus graft reaction)
    d. Atopy
A

A

38
Q
  1. The localized reactions to injected antigens in the same body site such as booster shoot are called____________
    a. Rheumatoid Arthritis (RA)
    b. contact dermatitis
    c. graft rejection
    d. Arthus reaction
A

D

39
Q
  1. A positive tuberculin skin test is an example of
    a. A delayed type allergy
    b. Acute contact dermatitis
    c. Autoimmunity
    d. Eczema
A

A

40
Q
  1. Contact dermatitis is cause by
    a. Pollen grains
    b. Chemical absorbed by the skin
    c. Microbes
    d. Proteins found in the food
A

B

41
Q
  1. A graft transplanted between individual who are members of different species
    a. allograft ( b/w geniticaly non-identical (allogenic) members of the same species)
    b. Xenograft
    c. Autograft (from one side to another site in the same individual.
    d. Isograft (syngraft) ( b/w genetically identical members of the same species, as identical (monozygotic) twins or member of an inbread mouse
A

B

42
Q
  1. Factors that affecting the immune system and decrease the immune functions are as follow:
    a. Chronic disease
    b. Long term physical activity
    c. Emotional stress
    d. A and C
A

D

43
Q
  1. Patient with severe immunodeficiency disease in both T – cells and B – cells compartment accept a allogenic bone marrow graft.
    a. True
    b. False
A

A

44
Q
  1. Natural antibodies have the following characteristics:
    a. Low affinity
    b. Low specificity
    c. Harmless
    d. Have some rule for clearing infection
    e. All of the above
A

E

45
Q
  1. In natural tolerance 95% of apoptosis (PCD) of T cells found in:
    a. bone marrow
    b. thymus
    c. lymph nodes
    d. spleen
A

B

46
Q
  1. Central Tolerance is within _______
    a. Bone marrow
    b. Thymus
    c. Lymph node
    d. Spleen
A

B

47
Q

Matching: Post-Streptococal (Glomerulonephritis)

A

Immune complex disease

48
Q

Matching: Arthrus Reaction

A

Type III hypersensitivity (local)

49
Q

Matching: Serum Sickness

A

Type III hypersensitivity (systemic)

50
Q

Matching: Contact Hypersensitivity

A

Type IV

51
Q
  1. T suppressor cells prevent _____ to make antibodies, and also prevent ________ from maturing into T –cytotoxic cells
    a. T cells, B cells
    b. B cells, T cells
    c. Macrophage, T cells
    d. B cells, macrophages
A

B

52
Q
  1. Preexisting infections can have positive or negative effects on immune response.
    a. True
    b. False
A

A

53
Q
  1. This is an induce tolerance in which an animal will failed to respond to non-self antigens (all exogenous antigens) from outside the body that would normally be immunologic.
A

Acquired tolerance

54
Q
  1. Which of the following factors are involved in autoimmune disease
    a. Infection
    b. Hormonal
    c. Genetic
    d. All of above
A

D

55
Q
  1. These monkey antigens (Rh factor) are presented in ___ of humans and absent in the other____
A

85%, 15%

56
Q
  1. Transfusion reaction may cause
    a. Destruction of the transfused cells by hemolysis opsonization
    b. Increased phagocytosis
    c. All of the above
A

C

Immunology (5 decks)

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