Final Flashcards
List two general (non-localizing) symptoms of brain tumors
headache nausea vomiting mental dullness decreased arousal (somnolence) seizures
What are the most benign neoplasms discussed in class?
Meningiomas
True or False: There are several types of neurons
True.
Sensory neurons
Motor neurons
Interneurons
The ion channels that are involved in depolarization during the action potential open in response to a change in ______
voltage
What structure is primarily responsible for maintaining the resting potential?
Sodium-potassium pumps
The axon ______ “decides” whether an action potential is created, or whether the neuron will pass along information or not
hillock
Name one specific type of cell responsible for myelination
Oligodendrocytes
Schwann cells
How is the resting potential maintained?
Inside neuron - negatively charged
Extracellular fluid - positively charged
Result is resting potential of ~70mV inside cell
Surplus of potassium ions inside cell
Deficit of sodium ions inside cell
Sodium ions pumped out to counter effect of diffusion across concentration gradient
Potassium ions pumped in to counter effect of diffusion across concentration gradient
Sodium-potassium pumps actively transport sodium out and potassium in at 3:2 rate
This active transport maintains the resting potential
Which ion is responsible for repolarization during the action potential?
Potassium (K+)
Dendrites transmit the signal _____ the cell body
toward
Axons typically have _____ terminal button(s) / end bulb(s)
more than one
True or False: The purpose of myelin is to increase the speed at which the electrical impulse travels
True
Potassium (K) channels are faster to open and close than sodium (Na) channels
False
List three symptoms of multiple sclerosis, one involving sensory function, one involving motor function, and one other symptom
Sensory function - Loss of vision
Motor function - Uncoordinated movement, weakness, leg dragging, stiffness.
Other symptom - Squeezing sensation around the torso
What complicates chemotherapy for brain tumors?
The action of the blood-brain barrier does not allow for chemicals in the blood stream to enter most parts of the brain
The element of the cytoskeleton that mediates axonal transport are called ______
microtubules
List two differences between axons and dendrites in a typical neuron
Dendrites exhibit arborization while axons are consistent in diameter and consist of a single tube
Dendrites pass information toward the soma while axons pass impulses away from the soma
What happens if the membrane at the “beginning” of the axon, near the soma, does NOT reach threshold?
The resting potential is maintained
True or False: During repolarization the neuron cannot fire an action potential.
True
The depolarization (rising) phase of the action potential is primarily caused by which of the following?
a. sodium flowing in
b. sodium flowing out
c. potassium flowing in
d. potassium flowing out
a. Sodium (Na) flowing in
The unmyelinated regions of myelinated axons are called nodes of ________
ranvier
What part of the neuron is involved in multiple sclerosis (MS)?
Axons
Which of the following would be the best way to make a pathway in your brain faster?
Reduce the number of synapses
True or False: The most common neurotransmitter in the human nervous system is an amino acid
True
Glutamate
If axodendritic synapses are like one-way streets, what type of synapse is like a two-way street?
Dendrodendritic
Neurotransmitter is removed from the synapse through enzymatic degradation, diffusion, and ______
reuptake
What ion signals vesicles to fuse with the presynaptic membrane?
Calcium (Ca+)
True or False: Excitatory postsynaptic potentials result in hyperpolarization.
False
Large molecule neurotransmitters are typically released in what type of synapse?
Non-directed
Which of the following is an example of an agonist?
a. Blocking a receptor
b. Preventing the breakdown of a neurotransmitter
c. Hindering synthesis of a neurotransmitter
d. Blocking the release of a neurotransmitter
b. Preventing the breakdown of a neurotransmitter
Stimulant drugs produce their effects by influencing which neurotransmitter?
Dopamine
At the synapse, communication is mediated chemically or electrically?
Chemically
List two differences between postsynaptic potentials and action potentials.
PSPs are decremental, graded, slower than APs, and are a passive process
APs are non-decremental, non-graded, faster than PSPs, and can be both active or passive processes
Why is it so easy to overdose on sedatives?
There are different receptors that will receive different sedatives, so multiple types of sedatives will not compete for receptors. The multiple types of receptors leads to a dangerous accumulation of sedative effects
True or False: Secondary seizures have no known etiology
False
Etiologies: Tumors Vascular lesions (strokes) Head trauma Infection Congenital defects High fever (febrile) Electrolyte imbalance Hypoglycemia Drugs
According to conditioned drug tolerance, in what type of environment is an individual most likely to overdose?
A novel environment different from the one in which they normally use.
______ is a group of disorders involving seizures.
Epilepsy
List two ways in which generalized seizures differ from partial seizures.
Generalized seizures affect a greater number of regions in the brain and are less common than partial seizures
Partial seizures are more localized to specific parts of the brain and have a greater prevalence than generalized seizures
True or False: Neurotransmitter receptors exist on both the presynaptic and postsynaptic membranes.
True
What is the difference between a directed and a non-directed synapse?
Directed synapses are specifically connecting one synapse to another, and are separated by a synaptic cleft on a receiving dendrite or soma
Non-directed synapses are not aimed at any particular synapse but rather release neurotransmitters into the extracellular fluid in a more diffuse, less directed manner
Two postsynaptic potentials impact a neuron at the same time but in different synapses. This is an example of what type of summation?
Spatial
According to the lecture, the brain structure involved in pleasurable experiences is called the _______
nucleus accumbens
Which part of the brain is most associated with balance and coordination?
Cerebellum
What are the two elements of the central nervous system (CNS)?
Brain and spinal cord
Damage to the reticular formation is most likely to create which of the following symptoms?
a. Heart attack
b. Coma
c. Poor judgment
d. Poor Coordination
b. Coma
For other parts of the nervous system to communicate with the cortex they usually have to go through the _______
Thalamus
What structure is responsible for maintaining body temperature, body weight, and other elements of a constant internal body environment?
Hypothalamus
If I cut off the top of your head, what plane would I be in?
Horizontal
The large commissure connecting the two hemispheres of the cortex is called the _________
corpus callosum
True or False: All cranial nerves are mixed nerves
False
What is the name of the secret lobe of the cortex that sits inside the Sylvian sulcus, the sulcus that is the superior margin of the temporal lobe?
Insula
Another name for efferent is _______
motor
The cerebral aqueduct divides the midbrain into the tectum and _______
tegmentum
Which part of the brain is most associated with thinking or cognition?
The cortex
What part of the cortex sends information to tertiary motor cortex?
Tertiary sensory cortex
True or False: The pons is superior to the medulla.
True
Superior to the medulla
Inferior to the midbrain
Anterior to the cerebellum
True or False: Subcortical nuclei are myelinated
False
Grey matter is, by definition, non-myelinated
What is a nerve?
A bundle of axons and dendrites - mostly axons
Identify one difference between the somatic and autonomic nervous systems
(Functional division of the nervous system)
Somatic - innervates striated muscles
Autonomic - innervates smooth muscles of internal organs (glands, blood vessels)
Identify one structure that is part of the limbic system
Cingulate gyrus Thalamus Hypothalamus Amygdala Hippocampus
Most of the human brain is subcortical white matter
False
Which of the following structures is most associated with basic functions like maintaining heart rate and blood pressure?
a. Cerebellum
b. Midbrain
c. Basal ganglia
d. Medulla
d. Medulla
What is the name of the structure that functions like a reservoir which receives blood from the heart then distributes it to the brain?
Circle of Willis
How many ventricles are in the human brain?
4
Cerebrospinal fluid (CSF) is made by glial cells in a type of capillary bed called _______ plexus
choroid
A weak area in the wall of a blood vessel is called a(n):
aneurysm
Regarding stroke, which of the following is NOT true?
a. Motor symptoms include weakness
b. Sensory symptoms include severe headache
c. Symptoms are usually unilateral
d. Symptom onset is usually slow
d. Symptom onset is usually slow
The vertebral arteries join to form what artery?
Basilar
What are the two parts to the definition of a concussion?
Impact to the head and any alteration of consciousness
What are the three functions of cerebrospinal fluid (CSF)?
Mechanical support - supports the weight of the brain and spine
Metabolite/waste product removal
Protection
True or False: The severity of a traumatic brain injury (TBI) is often measured by the duration of memory loss (amnesia).
True
Little Jimmy steps on the end of a rake and it swings up and hits him in the forehead. In this case the coup is located in what lobe of the cortex?
Frontal
True or False: All other factors being equal, hemorrhagic strokes are more severe than ischemic strokes.
True
The area of dead tissue following a stroke is called a(n) _______
infarct
Who is most likely to experience a traumatic brain injury (TBI)?
A male in their 20s