Final 1 Flashcards
With regards to API, which of following is ALWAYS true?
a. API binds appropriate cellular target and performs chemistry in body
b. API manufactured by chemical synthesis
c. API is a small molecule
d. API provides targeting to app organ/cell type
d. API provides targeting to app organ/cell type
In general, what is the impact on the relative stability of making a solution of a drug substance compared to the solid/particulate form?
a. it will be less stable
b. there will be no change
c. it will be more stable
d. you would never make a solution of a solid drug substance
a. it will be less stable
In a soft gel capsule, the API can be presented in ___
a. outer shell
b. a solid fill
c. a liquid fill
d. all of the above
c. a liquid fill
When choosing whether to produce tablets or capsules, what is one consideration is the speed at which the dosage forms can be produced?
a. Capsules and tablets are manufactured at about the same rate
b. Tablets are manufactured more slowly than capsules
c. Tablets are manufactured more quickly than capsules
d. Soft gel capsules are manufactured much more quickly than tablets or hard gel capsules
c. Tablets are manufactured more quickly than capsules
Which of the following is NOT one of the body’s defense mechanisms against nasal delivery?
a. mucous
b. presence of cilia on the nasal epithelium
c. sense of smell
d. the sneeze reflex
c. sense of smell
Which of the following types of liquid formulations will allow for the fastest onset?
a. suspension
b. emulsion
c. solution
d. they will all be the same
c. solution
When ocular drugs are administered systemically, what is the approximately bioavailability in the eye?
a. 25%
b. 1%
c. 10%
d. 5%
b. 1%
A compounded medication has ____
a. an expiration date
b. a retest date
c. a beyond use date
d. all the above, they are equivalent terms
c. a beyond use date
The skin is the largest organ, is very accessible, and presents a large surface area, making it attractive for drug delivery. The differences between topical and transdermal delivery are:
a. topical delivery is local while transdermal delivery is systemic
b. topical delivery is systemic while transdermal delivery is local
c. both topical and transdermal delivery can be used for either local or systemic delivery
d. none of these
a. topical delivery is local while transdermal delivery is systemic
What is the hallmark of most ear diseases?
a. inflammation
b. tinnitus
c. infection
d. hearing loss
a. inflammation
What type of oral formulation is most commonly extemporaneously (quickly) compounded?
a. tablet
b. soft gel tablet
c. hard gel tablet
d. caplet
a. tablet
Traditional ocular formulations deliver the drug ___
a. to the anterior segment of the eye
b. systemically
c. to the posterior segment of the eye
d. all of the above
a. to the anterior segment of the eye
Which of the following is NOT important consideration when designing a topical formulation?
a. ability of drug to cross dermis
b. dosage uniformity
c. physical stability
d. aesthetic appeal
d. aesthetic appeal
Which of the following is an invasive route of administration?
a. subcutaneous injection
b. rectal
c. pulmonary
d. all of the above
a. subcutaneous injection
True/False: Ocular and otic drug delivery require many of the same considerations when designing a formulation
True