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Virology > Filoviruses > Flashcards

Filoviruses Flashcards

1
Q

Filo

A

“Thread”

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2
Q

Genome?

A

Nonsegmented (-)ssRNA

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3
Q

Structure?

A

Helical nucleocapsid with an envelope

Distinct filamentous shape

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4
Q

Select pathogenic members

A

Ebolavirus and Marburgvirus

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5
Q

VAP?

A

Glycoprotein (GP)

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6
Q

Nucleoprotein (N/NP)

A

Coats the genome along with VP30 and VP24

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7
Q

L

A

Viral RNAP that complexes with VP35

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8
Q

VP40 (M)

A

Forms the matrix

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9
Q

Life cycle

A
  1. Attachment - glycoprotein binds host receptor
  2. Penetration - Endocytosis
  3. Entry - fusion at endosomal membrane triggered by lowering pH
  4. Uncoating
  5. Gene expression - via primary transcription
  6. Genome replication - using viral RNAP
  7. Assembly - at plasma membrane
    • release - via budding
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10
Q

Transcriptional polarity

A

3’ genes are transcribed more efficiently than 5’ genes because of polymerase stuttering at the polyUs between genes

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11
Q

Transmission

A

Bodily fluids
Fomites
Contaminated needles
Bushmeat

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12
Q

Reston ebolavirus

A

Infects pigs which infect more pigs and humans
Respiratory disease
Virus of zoonotic potential

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13
Q

Reservoir host

A

Bats

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14
Q

Sites of primary replication

A

Localized dendritic cells (and macrophages)

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15
Q

Receptor for site of primary replication

A

NPC1 which is expressed systemically

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16
Q

Sites of secondary replication

A

Lymphocytes
Innate immune cells
Almost all organs affected

17
Q

Ervebo (rVSV-EBOV)

A

Live-attenuated vaccine that is replication-competent
Single dose and uses Vesicular,sr Stomatitis Virus as vector and expresses EBOV GP not VSV GP

18
Q

Zabdeno/Mvabea (Ad26-ZEBOV/MVA-BN-Filo)

A

Adenovirus used to deliver EBOV GP RNA

Booster is Vaccinia Ankara virus (MVA) which encodes GP from EBOV, SUDV, and MARV

19
Q

cAd3-EBOZ (chAd3-EBO Z) with or without MVA-BN-Filo

A

Uses chimpanzee adenovirus to deliver EBOV GP RNA

Virology (18 decks)

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