fibrosis Flashcards
What is fibrosis?
Fibrosis is the excessive accumulation of extracellular matrix components, leading to tissue scarring and impaired function.
True or False: Fibrosis can occur in any organ of the body.
True
Fill in the blank: Fibrosis is primarily caused by ________.
chronic inflammation
What is the main cellular component involved in the formation of fibrosis?
Fibroblasts
Which cytokine is most commonly associated with promoting fibrosis?
Transforming Growth Factor-beta (TGF-β)
What is the role of myofibroblasts in fibrosis?
Myofibroblasts are responsible for the production of collagen and other extracellular matrix components.
List one common disease associated with pulmonary fibrosis.
Idiopathic pulmonary fibrosis (IPF)
What imaging technique is often used to diagnose pulmonary fibrosis?
High-resolution computed tomography (HRCT)
Multiple Choice: Which of the following is NOT a common cause of fibrosis? A) Alcohol abuse B) Viral infections C) Regular exercise D) Autoimmune diseases
C) Regular exercise
True or False: Fibrosis is always reversible.
False
What is the primary histological feature of fibrotic tissue?
Increased collagen deposition
Fill in the blank: The process of fibrosis is often initiated by ________ injury.
tissue
What is the main complication of liver fibrosis?
Cirrhosis
What type of collagen is predominantly found in fibrotic tissue?
Type I collagen
Multiple Choice: Which of the following is a potential treatment for pulmonary fibrosis? A) Corticosteroids B) Antibiotics C) Antivirals D) Antihistamines
A) Corticosteroids
What is the term for the process by which normal tissue is replaced with fibrotic tissue?
Fibrogenesis
True or False: Fibrosis can lead to organ failure.
True
What is the primary function of the extracellular matrix in fibrosis?
To provide structural support and regulate cell behavior.
Fill in the blank: In chronic liver disease, fibrosis can progress to ________.
liver cirrhosis
What is the role of matrix metalloproteinases (MMPs) in fibrosis?
MMPs are involved in the degradation of extracellular matrix components.
List one clinical manifestation of renal fibrosis.
Chronic kidney disease
What is the significance of the ‘honeycomb’ pattern seen on HRCT in pulmonary fibrosis?
It indicates advanced fibrotic changes in the lung.
Multiple Choice: Which of the following is a risk factor for developing systemic sclerosis? A) Smoking B) Obesity C) Female gender D) Sedentary lifestyle
C) Female gender
What type of immune response is typically involved in the development of fibrosis?
Chronic inflammatory response
