Fibrinolytics

Question 1

What is the fibrinolytic pathway?

Answer 1

Plasmin breaks down your clot. To get plasmin from plasminogen, you need t-PA. t-PA is kept in check by PAI-1.

Question 2

What are the drug targets of Alteplase and tenecteplase?

Answer 2

t-PA

Question 3

Alteplase is ?
What’s the half life?
requires what?

Answer 3

recombinant t-PA
Half life is 5 mins
requires extended IV infusions

Question 4

Tenecteplase is ?
Has changes to ___?
More specific binding to ?
More resistant to ?
Half life is?
Dosed as a ?

Answer 4

modified recombinant t-PA

3 amino acids (T,N,K)

fibrin

PAI-1
20 min initially, 2 hrs terminal

Single IV bolus