Fibrinolysis

Question 1

What is primary haemostasis?

Answer 1

Interactions between blood vessels, platelets and VWF

Question 2

What is secondary haemostasis?

Answer 2

pathways of coagulation to generate a fibrin strand

Question 3

What is fibrinolysis?

Answer 3

A biochemical system that degrades the fibrin clot through proteolysis. This protects against vascular occlusion by preventing fibrin formation in excess of what is needed to prevent blood loss

Question 4

What is tissue plasminogen activator?

Answer 4

The main activator turning plasminogen into plasmin

Question 5

What is plasminogen?

Answer 5

A single polypeptide chain that is activated through the intrinsic pathway

Question 6

What is activated along with the coagulation reaction?

Answer 6

Inhibitory reaction to control and limit the clotting process

Question 7

What are serpins?

Answer 7

A group of protease inhibitors produced by hepatocytes.They are inefficient in absence of co-factors, which is provided by heparin sulphate. They form stable 1:1 complexes with their target enzymes

Question 8

What does protein C do to coagulation factors?

Answer 8

It is synthesised in the liver and inhibits factor 8 and 5. But it is vitamin K dependent and needs to be carboxylated to be activated

Question 9

What is the difference between arterial and venous thrombi?

Answer 9

Arterial is composed of primarily platelets and fibrin with few RBC, while venous is composed of primarily RBC trapped in a fibrin mesh. Arterial often form on atherosclerotic plaques, while venous can occur anywhere but most common in lower limbs. Arterial treated with antiplatelet, while venous treated with anticoagulant