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Hematology II > FIBRINOLYSIS > Flashcards

FIBRINOLYSIS Flashcards

1
Q

The last stage of coagulation

A

Fibrinolysis

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2
Q

Fibrinolysis is Comprised of

A

A systemic hydrolytic digestion of cross-linked fibrin polymers by bound plasmin.

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3
Q

the physiologic process of removing unwanted fibrin deposits , represents a gradual progressive enzymatic cleavage of fibrin to soluble fragments.

A

Fibrinolysis

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4
Q

Fribrinolysis fragments are then removed by

A

the fixed macrophages of the MPS. (mononuclear phagocytic system).

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5
Q

Components of Fibrinolysis

A
  1. Plasminogen - Plasmin
  2. Tissue plasminogen activator (TPA)
  3. Urokinase
  4. Streptokinase
  5. Plasminogen activator inhibitor-1 (PAI-1)
  6. A2- antiplasmin
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6
Q

Produced by liver (Components of fibrinolysis)

A

PLASMINOGEN
A2-Antiplasmin

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7
Q

Serine Protease (components of Fibrinolysis)

A

TPA
UROKINASE

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8
Q

Produced by activated endothelium

A

TPA

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9
Q

What component of fibrinolysis id being produce by Kidneys

A

Urokinase

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10
Q

Plasminogen half life

A

24-26 hours

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11
Q

Streptokinase is produced by

A

B-hemolytic strep

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12
Q

PAI-1 is produced by

A

Endothelium

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13
Q

Inhibits TPA

A

PAI-1

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14
Q

Inhibits plasmin

A

A2-antiplasmin

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15
Q

The fibrinolytic system is mediated mainly by the enzyme plasmin, which acts primarily on fibrin to produce lysis of the clot.

A

Plasminogen

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16
Q

Plasmin is generated from the inactive zymogen

A

Plasminogen

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17
Q

Plasminogen is activated to plasmin by

A

TPA AND OTHER SUBSTANCES

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18
Q

Plasminogen is synthesize by

A

Liver

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19
Q

Half life of plasminogen

A

2 days

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20
Q

Plasminogen 2 forms

A

Lys
Glu

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21
Q

What form of plasminogen is more readily converted to active plasmin.

A

Lys

22
Q

ENDOGENOUS ACTIVATORS

A

FACTOR XIa , XIIa and Kallikrein

23
Q

EXOGENOUS ACTIVATORS

A

Tissue plasminogen activator
Urokinase
Streptokinase

24
Q

the main activator of plasmin in-VIVO (sulod).

A

TPA

25
Q

Potent fibrinolytic agent by activating
plasminogen.

A

TPA

26
Q

acts as the major release inducer.

A

Thrombin

27
Q

minor role in in-VIVO fibrinolysis.

A

Urokinase

28
Q

Genitourinary system product

A

Urokinase

29
Q

Has Lower a nity with fibrin

A

Urokinase

30
Q

Produced by B-hemolytic streptococci

A

Streptokinase

31
Q

Indirectly activates plasminogen

A

Streptokinase

32
Q

A group of substances referred to as

A

Serpins (Serine Protease inhibitors)

33
Q

Primary inhibitor of tPA and Urokinase.

A

Plasminogen activator inhibitor-1

34
Q

has the ability to proteolytically degrade both fibrin and fibrinogen in clots formed and native fibrinogen in the circulation.

A

Plasmin

35
Q

The degraded products of plasmin is collectively termed as

A

FIBRIN/FIBRINOGEN DEGREDATION PRODUCTS

36
Q

Proteolytically cleave and render inactive factors

A

V and VIII and XII

37
Q

Plasmin Proteolytically cleave

A

GPIB complexes.

38
Q

The earliest recognizable unit fragment is

A

FRAGMENT X

39
Q

The Y fragment is further degraded to produce and additional D fragment and a single

A

E fragment

40
Q

Fragment X gets cleaved further by plasmin to yield unclottable fragment

A

Y and D.

41
Q

Crosslinked fibrin cleavage will produce the

A

D-dimer

42
Q

exhibits anticoagulant e ect by competing with fibrinogen for thrombin.

A

Fragment X

43
Q

forms abnormal complexes with fibrin monomers as it polymerizes.

A

Fragment D

44
Q

no known anticoagulant

A

Fragment E

45
Q

the major in-vivo plasmin inhibitor.

A

A2- plasmin inhibitor

46
Q

A2- macroglobulin

A

Has a role in plasmin inhibition during Normal hemostasis.

47
Q

Participates only when a2-antiplasmin inhibitor binding sites are saturated.

A

A2- macroglobulin

48
Q

Inhibits fibrinolysis by hydrolyzing lysine from the carboxyl end of fibrin.

A

Thrombin-activatable fibrinolysis inhibitor (TAFI)

49
Q

Activated by Thrombin-thrombomodulin complex.

A

Thrombin-activatable fibrinolysis inhibitor (TAFI)

50
Q

Fragment X gets cleaved further by plasmin to yield unclottable fragment

A

fragment Y and D.

Hematology II (17 decks)

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