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Hematology II > Coagulation Part 1 > Flashcards

Coagulation Part 1 Flashcards

1
Q

Plasma transports at least 16 procoagulant, also called

A

Coagulation factors

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2
Q

coagulation factors (synthesized in the

A

Liver

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3
Q

How many zymogens

A

Eight

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4
Q

the International Committee for the Standardization of the Nomenclature of the Blood Clotting Factors o cially named the plasma procoagulants using Roman numerals in the order of

A

their initial description or discovery

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5
Q

Is the primary substrate of thrombin

A

Fibrinogen

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6
Q

Is the primary enzyme of the coagulation system

A

Fibrinogen

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7
Q

Is essential for platelet aggregation

A

Fibrinogen

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8
Q

Normal plasma conc.: fibrinogen

A

200-400 mg/dL

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9
Q

Is the most concentrated of all the plasma
procoagulants

A

Fibrinogen

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10
Q

Is an acute phase reactant protein

A

Fibrinogen

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11
Q

a mirror-image dimer

A

Fibrinogen Molecule

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12
Q

six N-terminals assemble to form a bulky
central region

A

E domain

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13
Q

three carboxyl terminals on each
outer end of the molecule

A

Two D domain

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14
Q

Activated form: of Prothrombin

A

Thrombin

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15
Q

Is the main enzyme of the coagulation pathway with multiple key activities.

A

Prothrombin

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16
Q

Cleave fibrinopeptides (FP) A and B from the alpha and beta chains of the fibrinogen molecule.

A

Prothrombin

17
Q

The cleave fibrinogen

A

Fibrin monomer

18
Q

Functions of thrombin:

A

● Activates cofactors V and VIII and factor XI by a positive feedback mechanism
● Activates factor XIII
● Initiates platelet aggregation
● Activates the protein C pathway

19
Q

How does protein c activated

A

Thrombomodulin-Thrombin Complex

20
Q

Activation of Protein C: destroys

A

Destroys FV and FVIII

21
Q

Thrombin-thrombomodulin also activates

A

TAFI

22
Q

Are named the prothrombin group because of their structural resemblance to prothrombin

A

Vitamin K-Dependent Prothrombin Group

23
Q

Is a quinone found in green leafy vegetables and is produced by the intestinal organisms

A

Vitamin K

24
Q

a quinone found in green leafy vegetables and is produced by the intestinal organisms what organism?

A

Bacteroides fragilis and Escherichia coli

25
Q

Catalyzes an essential posttranslational modification of the prothrombin group (glutamic acid is modified to y-carboxyglutamic acid when a second carboxyl group is added to the y carbon)

A

Vitamin K

26
Q

Proteins Induced by Vitamin K Antagonists (PIVKA) factors also known as

A

des-y-carboxyl proteins

27
Q

Cannot participate in the coagulation reaction because they lack the second carboxyl group

A

Proteins Induced by Vitamin K Antagonists (PIVKA) factors

28
Q

Results from Vitamin K deficiency or in the presence of Coumadin

A

Proteins Induced by Vitamin K Antagonists (PIVKA) factors

Hematology II (17 decks)

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