Fever - Naren Flashcards
What is the most accurate place to measure temperature to estimate core temp?
esophagus, at the cardia.
This is not so easy to do, so rectal is the next best.
What is an exogenous factor? Endogenous?
something outside the body, like external temperature or humidity, physical activity, diet, or insulation.
Something inside the body, like progesterone, which increases temp; rhythms, gender, subcutaneous insulation
What is the best way to get rid of heat?
evaporation
Where is main control of temperature in the body located?
hypothalamus
Where are warm fibers located?
In Ruffini’s corpuscles.
Where are cold fibers located?
in the end-bulb of Krause
What channel do warm fibers use to send signals? What artificial substance is commonly used to activate it as a thermal pain therapy?
TRPV3. Capsaicin
Why does menthol generate a cold sensation?
It activates the cold fiber signal channels
What effect on temp will sympathetic nervous activation have?
Fight or Flight. It will cause increased metabolism, activity, and vasoconstriction to periphery so body temperature will rise
Would you expect hyper or hypothermia in a patient with severe goiter?
Goiter is a result of iodine deficiency. This will decrease thyroid function (hypothyroidism) and decrease metabolism and heat production, making the patient more susceptible to hypothermia
Which nervous system triggers sweat gland action?
sympathetic
What organ triggers signals to cause diaphoresis?
diaphoresis is sweating. Hypothalamus
What is CFDR?
a gene that controls ion channels across mucosa and glands. When defective, Cystic fibrosis.
Whose core temperature cools more slowly: men or women?
Women.
Though men have higher body temperature and are able to produce more heat; women core temperature stays warmer longer.
The extremities of women are in greater risk of cold damage though.
What evnironmental temperature would cause increase in epinephrine secretion?
cold.
epinephrine stimulates heat production.
What are the upper and lower temp limits for survival?
20-45 C, 74-114 F
What is heat exhaustion?
the bodies respond to increased temp.
Vasodilation, sweating.
sweating can decrease ECF and blood volume, leading to hypotension and fainting.
What is heat stroke?
body temp increases to point of damage. Usually happens because of impaired temp regulatory controls.
What is malignant hyperthermia?
rare life threatening condition (usually hereditary) where a massive increase in metabolic rate and O2 consumption occur in response to inhalation anesthetics (halothanes)
How can alcohol impair the bodies ability to react to extreme heat?
alcohol suppresses the sympathetic nervous system, impairing temperature regulation in either direction.
What molecular signal resets hypothalamus temperature?
PGE2. This is upregulated by immune and inflammatory responses.
