Fetal growth Flashcards

1
Q

Define fetal growth

A

Increase in mass that occurs between end of embryonic period and birth

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2
Q

Simplest way of determining size of infant

A

Palpating maternal abdomen to find symphysis fundal height

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3
Q

What is symphysis fundal height

A

Distance between pubic bone and top of the uterus

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4
Q

Why is symphysis fundal height vulnerable to a variety of errors

A

Data can be lower than actually is due to:
Wrong last period date
Baby is lying transversely
Oligohydramnios

Data can be higher due to:
Maternal obesity
Wrong last period date
Multiple pregnancy

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5
Q

What is oligohydramnios

A

Low amniotic fluid levels

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6
Q

Complications assocaited with baby being larger than expected on SFH

A

Molar pregnamcy
Fibroids
Polyhydramnios
Large baby

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7
Q

What is a molar pregnancy

A

Formed from a previous implanted failed blastocyst that has become a mass

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8
Q

What 4 things are combined to guve estimated fetal weight

A

Biparietal diameter
Head circumfrence
Adbdominal circumfrence
Femur length

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9
Q

What is done with ultrasound data

A

The changes in each parameter are plotted and growth over time is visualised- they are expected to follow a centile showing a steady increase in growth

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10
Q

Why are centiles used totrack growth of fetus’

A

Allows compensation for different sized babies and shows their development is normal

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11
Q

Differences in growth velocity across term

A

14-15 wks= 5g/day
20wks= 10g/day
33wks= 30g/day
>34wks= growth rate drops

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12
Q

Characterisation of normal fetal growth

A
Cellular hyperplasia (increased cell numbers): 4-20 weeks
Hyperplasia and hypertrophy (increased cell size): 20-28 weeks
Hypertrophy dominates: 28-40 weeks
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13
Q

What is main key factor in fetal weight gain

A

Hypertrophy as most weight gain occurs in final trimester

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14
Q

Issue of using last menstrual period to date pregnancy

A

Confounding factors include irregular length of periods, endometrial bleeding that is abnormal, oral contraceptive use and breastfeeding
Also people who have had unplanned pregnancies are much less likely to be aware of their most recent period

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15
Q

What is best practice to date pregnancy now

A

Crown rump length

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16
Q

How does poverty affect fetal growth

A

Less educated about use of things such as alcohol use during pregnancy
More likely to have disease which can affect baby
More likely to have a baby at younger age

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17
Q

Ideal age for pregnancy for healthy fetus environment

A

16-35

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18
Q

Problem with having baby over 35

A

More inclined to have long pregnancy-> increased risk of death to mother and fetus
More likely to have preterm labour
Increased risk of downsyndrome

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19
Q

Problem with havng baby under 16

A

More likely to have preterm labour which can lead to neurological issues such as irritability, crying and trouble sleeping which affect coping of mother

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20
Q

Effects of weed use during pregnancy

A
Slows fetal growth
Premature delivery
Low birth weight
Delivery complications
Can lead to addiction
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21
Q

Effects of heroin use during pregnancy

A
Interrupted development
Stillbirths
Preamture births
GI issues
Large head
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22
Q

Effects of cocaine use during pregnancy

A

Smaller brain so learning issues
Stillborn
Premature

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23
Q

Effects of alcohol use during

A

Facial abnormalities

Affects brain and CNS development -> behavioural issues and retardation

24
Q

Symptoms of fetal alcohol syndrome

A

Brain abnormalities
Cognitive deficits
Distictive facial features

25
Effects of nicotine use on feal blood supply during
Nicotine constricts blood vessels reuding oxygen supply to baby-> still births
26
Effects of nicotine use on baby if survives
Low weight | increased asthma risk due to resp effects
27
Effect of low iron diet on fetus
Anaemia
28
Effect of low calcium diet on fetus
Poor bone and teeth develpment
29
Effect of low protein diet on fetus
Retardation | Smaller fetus
30
Effect of maternal depression on fetus
Slower fetal growth | Associated with maternal cortisol levels
31
Effect of gender on fetal growth
Males are bigger
32
Effect of previous pregnancies on fetal growth
Infants are bigger in subsequent pregnancies
33
Effect of insulin on fetal growth
Increases nutrient delivery and mitotic drive not the differentiation of tissue Modulates IGF Affects adipose tissue
34
Effects of cortisol on fetal growth
Tissue differentiation and maturation
35
How does cortsiol affect fetal growth
Directly on cells by altering transcription and post translastional modification- also may initiate switch from IGF II to IGF I
36
Effect of thyroxine on fetal growth
affects tissue accretion and differentiation
37
Effect of pituitary growth hormone on fetal growth
Very little
38
Difference between IGF II and I in fetal growth
II involved in embryonic develompment and I in growth of newborn
39
Effects of fetal glucocorticoids
Maturation of surfactant in lungs Control of glycaemia in liver Maturation of the expression of digestive enzymes Proliferation of the villi
40
Proof growth hormone has no effect on growth in fetus
No defects present at birth of individuals with deficits
41
Growth factors affecting fetal growth
Epidermal growth factors Fibroblast growth factors Transforming growth factor
42
Define small for gestational age
Infant has birth weight <10th centile
43
Define intrauterine growth restriction
Failure for infant to achieve its predetermined genetic potential
44
How heavy is low birth weight
less than 2500g at delivery
45
How heavy is very low birth weight
less than 1500gmat delivery
46
How heavy is extremely low birthweight
less than 1000g at delivery
47
What is linked with IUGR
pre-eclampsia
48
What is pre-eclampsia
Diminshed re-mdelling of spiral arteries by cytotrophoblasts
49
What is pre-eclampsia associated with
Hypertension and proteinuria
50
Treatment for pre-eclampsia
Corticosteroids
51
Receptor for all growth factors
Tyrosine kinase linked
52
How are neurotransmitters inhibitted
During development cells do have muscarinic receptors on suface but ebryonic cholinesterase is very active through morphogenesis
53
Most common factor amongst stillbirths
IUGR
54
Short term complications of IUGR
``` Respiratory distress Intraventricular haemorrhage Sepsis Hypoglycaemia Necrotising enterocolitis Jaundice Electrolyte imbalance ```
55
Moderate term complications of IUGR
Respiratory problems Developmental delay Special needs schooling
56
Long term complications of IUGR
Fetal programming
57
When does most IUGR occur
Second and third trimester- this is where most growth occurs