Fetal and Neonatal Medicine Flashcards

1
Q

What to take into consideration for maternal hx

A
GBS status
Mom's age, ethnicity, SES
PMHx, social hx, exposures
Prior pregnancies and outcomes
Present pregnancy
Labor and delivery
Half of perinatal mortality and morbidity results from pregnancies identified before delivery as high-risk
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2
Q

Pregnancy complications

A

Maternal HTN, DM, idiopathic thrombocytopenic purpura (ITP), hyperthyroid?
Anemia and hypoxia are concerns with placental problems
Multiple gestations?
Problems with amount of amniotic fluid volume?
-Oligohydramnios is worse than polyhydramnios
–4x more common
–Can cause faulty lung development
How was baby delivered? Why?
-If C-section, how long did labor last beforehand?
Any issues at time of delivery?
-CP?
-Meconium?
–Below cords can cause inhalation pneumonia
-Shoulder dystocia?
–Brachial plexus or clavicle injury

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3
Q

How can maternal DM affect the newborn?

A

Risk of limb deformities, congenital heart dz, large for gestational age, hypoglycemia, shoulder dystocia
DM type I is high risk- must be in fantastic control before pregnancy

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4
Q

How can maternal heart dz or HTN affect the newborn?

A

Risk of IUGR

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5
Q

How can maternal drug addiction affect the newborn?

A

Neonatal abstinence syndrome

This problem is made worse by the criminalization of pregnancy and drug use: mothers avoid prenatal care

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6
Q

Jaundice and causes

A
Indicates too much bilirubin in the blood
Physiologic 
Breast milk
Rh incompatibility
Gilbert syndrome
Criggler-Naijar syndrome
Rotor syndrome
Dubin Johnson syndrome
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7
Q

Physiologic jaundice

A

Liver is immature
Starts 24 hrs after birth, gets worse thru days 3 or 4, then gets better
Rise per day is <5 mg/dL, peak never exceeds 15 mg/dL
Happens bc their bodies are inefficient in clearing bilirubin

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8
Q

Breast milk jaundice

A

Pregnanediol in milk interferes with conjugation of bilirubin
Bili level may get as high as 20 mg/dL
Tx: may need phototherapy, if level reaches 20 may suspend breastfeeding x 24 hrs

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9
Q

Rh incompatibility- jaundice

A

Jaundice starts earlier and is worse

Caused by either isoimmunization or A-B-O incompatibility

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10
Q

A-B-O incompatibility happens when…

A

The mother is type O and the baby is B, A, or AB
The mother is type A and their baby is B or AB
The mother is type B and the baby is A or AB

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11
Q

Causes of jaundice when it appears at birth or within first 24 hrs of life

A

Rh incompatibility

Sepsis

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12
Q

Causes of jaundice when it appears on 2nd and 3rd day of life

A

Physiologic jaundice
Breast milk jaundice
Criggler Naijar syndrome

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13
Q

Causes of jaundice when it appears on 3rd-7th day of life

A

Infective causes

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14
Q

Causes of jaundice when it appears after 7th day of life

A

Other syndromes

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15
Q

Sx of jaundice in newborns

A
Yellow skin/sclera
Sleepiness
Poor feeding
Dark urine
May progress (untreated) to fever, vomiting, and high-pitched cry (kernicterus)
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16
Q

Yellow skin/sclera in jaundice

A

Bili >5 mg/dL = jaundice in babies (>2 in adults)
As level increases, you see jaundice more distally
5 mg/dL = head and neck
10 mg/dL = trunk and arms
15 mg/dL = legs as well
20 mg/dL = palms and soles

17
Q

Kernicterus

A

Bilirubin encephalopathy caused by bilirubin’s toxicity to the basal ganglion. Bilirubin is lipid soluble and can cross the blood brain barrier.

18
Q

Phase 1 of kernicterus

A

Hypotonia
Poor suck response
Lethargy
Altered sensorium

19
Q

Phase 2 of kernicterus

A

Fever

Hypertonia going to opisthotunus (bent backwards)

20
Q

Phase 3 of kernicterus

A

High-pitched cry
Seizures
Death

21
Q

Consequences of kernicterus

A

Long-term survivors severely impaired

  • CP
  • UPward gaze palsy
  • Sensorineural hearing loss
22
Q

When is kernicterus more likely to occur?

A

Babies born with asphyxia, prematurity, or sepsis

23
Q

Tx for jaundice

A

Increase PO intake
- >10 needs supplementation
Phototherapy
-Eyes need protection against retinal damage
Babies with kernicterus may need exchange transfusions and tx with barbiturates that enhance conjugation of the bili

24
Q

Things that affect evaluation of the neonate

A

Full term or preterm?\
Average for gestational age? Small for gestational age? Large for gestational age?
APGAR score at birth?

25
Q

How to determine gestational age by exam

A

What is the baby’s resting posture? Flexion? Partial flexion? Extension?
Perform square window, arm recoil, popliteal angle, scarf sign, ad heel to ear
Examine skin for lanugo and vernix
-Micropreemies don’t have lanugo
Examine the palmar and sole creases
-Full term has creases on foot
Palpate the breast tissue: flat? Breast bud?
Examine the ear: how well-formed is the cartilage
-Preemie ears don’t bounce back
Genital exam. Boy: rugae? Means closer to term. Are the testes descended? Girl: do the labia cover the clitoris?

26
Q

Risks of prematurity

A

Respiratory distress

27
Q

Risks of IUGR

A

Increased risk of mortality, possibly acidotic from birth asphyxia, possible hypotension and/or hypoglycemia

28
Q

Causes of symmetrical IUGR

A

TORCH infections

29
Q

Causes of asymmetrical IUGR

A

Poor placental perfusion due to smoking or maternal HTN

30
Q

Common morbidities associated with prematurity

A
Congenital anomalies
Infection
Intraventricular hemorrhage
-Dx by u/s
Necrotizing enterocolitis
-Dx by hemoccult
Respiratory distress syndrome
-Ground glass appearance on CXR; tx with surfactant
Chronic lung dz when older
31
Q

When is there increased risk for chronic lung dz when older in preemies?

A

RSV
More frequent infections
Asthma
Bronchopulmonary dysplasia (mimics asthma but seen in preemies treated for resp. distress)

32
Q

Morbidities in full term infant

A

Complications of birth asphyxia: brain damage, CP, seizures, profound hypoglycemia
Birth trauma: fxs, palsies
- Clavicle or humerus MC
-Brachial plexus injuries not uncommon after difficult births of large babies
Congenital anomalies: palate, GI or GU tract
Congenital heart defects: MC VSD, most common CYANOTIC defect Tetralogy of Fallot

33
Q

What are the palate, GI, or GU tract anomalies?

A

Cleft lip and/or palate
Esophageal atresia, pyloric stenosis, malrotation (volvulus), omphalocele, gastroschisis
Epispadias or hypospadias, ambiguous genitalia, bladder exstrophy