FERGU - antidiuretics Flashcards
carbonic anhydrase inhibitor eg, location, MOA
acetazolamide, PT, inhibit CA (inhibit Na+ & HCO3- reabs,)
loop diuretic eg, location, MOA
furosemide; LoH; inhibit NKCC (a high ceiling diuretic)
thiazide eg, location MOA
HCTZ; distal tubule; inhibit Na/Cl cotransporter
furosemide drug class, indication, SE
loop diuretic; edema, HTN; hypokalemia, metabolic alkalosis, hyperuricemia (gout), ototoxicity (esp if combined with aminoglycosides)
acetazolamide drug class, indication, SE
Carbonic anhydrase inhibitor; glaucoma, acute mountain sickness; metabolic acidosis, renal stones (alkaine), hypokalemia
HCTZ drug class, indication, SE
thiazide diuretic (increases Ca++ reabs, a bonus); edema, HTN, nephrogenic diabetes insipidus; hypokalemia, metabolic alkalosis, hyperuricemia, hyperlipidemia, hyperglycemia
osmotic diuretic eg, location, MOA
mannitol; within the tubule; freely filtered but stay within tubule, pulls water into lumen throughout (but limited utility as diuretic)
potassium-sparing diuretic (2 types) eg, location, MOA
aldosterone receptor blocker-spironolactone, ENaC blocker-amiloride, triamterene; late DT/early CCD; blocks aldosterone action on ENaC & Na/K ATPase, or blocks ENaC
mannitol drug class, indication, SE
osmotic diuretic; mainly non-diuretic indications; increased intracranial pressure
spironolactone drug class, indication, SE (what’s the alternative?)
K sparing diuretic (aldosterone receptor blocker); HTN, CHF; hyperkalemia, antagonism of androgen/progesterone receptors (gynecomastia, dysmenorrhea), use eplerenone instead
V2 antagonist, MOA
tolvaptan; prevent ADH from acting on V2 to place aquaporins in CD
vasopressin (exogenous drug)
selective V1 agonist, vasoconstricts; may be used to Tx shock in ICU
DDAVP what is it?
V2 agonist, leads to water reabs
