Female treatment

Question 1

Treatment for mucus build up within cervix

Answer 1

Intrauterine insemination - cost effective first line treatment
Less invasive compared to other in-vitro fertilisation methods
Reasonable success rates 3-4 cycles (Ombelet 2018)

Question 2

Intrauterine insemination

Answer 2

Concentrated sperm placed directly into uterus day after ovulation is induced
Use drug - clomiphene citrate in combination with gonadotrophin

Question 3

Better ovulation stimulants other than clomiphene citrate and gonadotrophin

Answer 3

Study by Sinha and Agrawal 2015
100 coules
52 couples with gonadotrophin alone had better pregnancy rates 33.3% compared to 18.36% with combination

Question 4

Cervical mucus removal treatment

Answer 4

Maher et al 2018 
714 patients 
Concluded cervical mucus removal before IUI
Improve pregnancy outcome 
Mucus removal 31% resulted in pregnancy 
Compared to 21.8% without it

Question 5

How to remove mucus

Answer 5

Use insemination catheter

Question 6

Maher et al 2018 study problem..

Answer 6

Study didn’t specifically identify women with actual hostile mucus
Results questionable

Question 7

Treatment for immotile cilia and endometriosis

Answer 7

IVF

Question 8

IVF procedure..

Answer 8

Ovary stimulation (FSH with GnRH), egg and sperm removal
In vitro fertilisation and embryo transfer to uterine tubules

Question 9

Risk of IVF

Answer 9

Hyperstimulation shown in 130 cases of multiple pregnancies (Kathpalia et al 2016)
Negative for mother and baby

Question 10

Side effects of IVF

Answer 10

Meta analysis of 41 studies by Giogione et al 2017

Foetuses conceived by IVF had increased risk of CHD

Question 11

Success rate of IVF between 2014-2016

Answer 11

29% - although this decreased as age of mother increased (NHS 2016)

Question 12

Religious believes

Answer 12

GIFT may be used where both sex cells are inserted directly into uterine tubes to allow fertilisation
Success rates similar to that of IVF