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Endo/Repro Wk 3 > Female Pharmacology > Flashcards

Female Pharmacology Flashcards

1
Q

Clomiphene
MOA
TU
Tox

A

MOA: selective estrogen antagonist in hypothalamus, decreases negative feedback in hypothalamus leading to increased levels of FSH and LH
TU: fertility drug, folliculogenesis
Tox: hot flashes

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2
Q

Leuprolide
MOA
TU

A

MOA: GnRH agonist
initial surge in LH and FSH –> eventual desensitization after 10 days
OR
pulse doses –> continued increase of LH and FSH
TU: follicle stimulation (pulses), endometriosis when given continuously

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3
Q

-relix
MOA
TU

A

MOA: GnRH antagonists
TU: prevent endogenous LH surge while promoting folliculogenesis w/ exogenous gonadotropin

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4
Q

Clomiphene
MOA
TU
Tox

A

MOA: antagonist at estrogen receptors in hypothalamus
=> upregulation of FSH and LH -> stimulates ovulation
TU: pregnancy due to anovulation
Tox: hot flashes, multiple pregnancies

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5
Q

Tamoxifen
MOA
TU
Tox

A

MOA: estrogen antagonist in breast, agonist in endometrium and bone
TU: estrogen-sensitive breast ca
Tox: thromboembolic events, endometrial ca

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6
Q

Raloxifene
MOA
TU
Tox

A

MOA: estrogen antagonist in breast and endometrium, agonist in bone
TU: osteoporosis
Tox: thromboembolic events

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7
Q

Toremifene
MOA
TU
Tox

A

MOA: estrogen antagonist in breast and endometrium
TU: estrogen-sensitive breast ca
Tox: hot flashes, improve cholesterol

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8
Q

Fulvestrant
MOA
TU
Tox

A

MOA: full estrogen antagonist
TU: estrogen-sensitive breast ca
Tox: thromboembolic events, hot flashes

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9
Q

Anastrozole
MOA
TU
Tox

A

MOA: reversible aromatase inhibitor
TU: estrogen-positive breast ca
Tox: hot flashes

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10
Q

Letrozole
MOA
TU
Tox

A

MOA: reversible aromatase inhibitor
TU: estrogen-sensitive breast ca
Tox: hot flashes

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11
Q

Exemestane
MOA
TU
Tox

A

MOA: irreversible aromatase inhibitor
TU: estrogen-sensitive breast ca
Tox: hot flashes

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12
Q

Levonogestrel
MOA
TU

A

MOA: progesterone agonist -> prevents ovulation
TU: emergency contraception

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13
Q

Mefepristone
MOA
TU

A

MOA: progesterone antagonist -> pregnancy termination
TU: pregnancy termination

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14
Q

Ulipristal
MOA
TU

A

MOA: progesterone antagonist -> pregnancy termination
TU: emergency contraception, pregnancy termination

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15
Q

Misoprostol
MOA
TU

A

MOA: PGE1 agonist
TU: pregnancy termination w/ high dose mefepristone

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Endo/Repro Wk 3 (9 decks)

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