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Repro Exam I > Female Gonadal hormones > Flashcards

Female Gonadal hormones Flashcards

1
Q

Conjugated estrogens

A

Estrogen analog

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2
Q

Estradiol valerate

A

Estrogen analog

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3
Q

Ethinyl estradiol

A

Estrogen analog - most common in BC

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4
Q

Mestranol

A

Estrogen analog

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5
Q

Desogestrel

A

Progestin analog - inactive prodrug

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6
Q

Etonogestrel

A

Progestin analog - active metabolite

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7
Q

Drospinenone

A

Progestin analog

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8
Q

Medroxyprogesterone

A

Progestin analog

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9
Q

Norethindrone

A

Progestin analog

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10
Q

Norgestimate

A

Progestin analog

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11
Q

Norgestrel

A

Progestin analog

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12
Q

Mifepristone

A

Progesterone R antagonist (and glucocorticoid R)

terminate early pregnancies

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13
Q

Raloxifene

A

Selective estrogen receptor modulator
agonist on lipids and bone
antagonist on endometrium and breast

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14
Q

Tamoxifen

A

Selective estrogen receptor modulator
antagonist on breast - agonist other tissues
increased endometrial cancer risk

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15
Q

Toremifene

A

Selective estrogen receptor modulator
antagonist on breast - agonist other tissues
increased endometrial cancer risk

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16
Q

Clomiphene

A

Selective estrogen receptor downregulator

17
Q

Fulvestrant

A

Selective estrogen receptor downregulator

18
Q

Anastrazole

A

Aromatase inhibitor - inhibit estrogen synthesis from androgens(post menopausal happens in peripheral tissue) - treat breast cancer in postmenopausal women
fewer side effects than SREMs

19
Q

Exemestane

A

Aromatase inhibitor

20
Q

Letrozole

A

Aromatase inhibitor

21
Q

What drug combinations are used for hormone contraception?

A

Estrogen-progestin

Progestin only - fewer adverse effects

22
Q

What drug combinations are used for postmenopausal hormone replacement therapy?

A

Estrogen - especially if no uterus

Estrogen-progestin combinations

23
Q

What drugs are used to treat hormone response breast cancer and infertility?

A

anti-estrogens

24
Q

What drugs to prevent breast cancer and osteoporosis?

A

Selective estrogen receptor modulators

25
Q

What drugs for medical abortion?

A

anti progestin

26
Q

Adverse effects of theraputic estrogens

A

Uterine bleeding
breast cancer
endometrial cancer - use w/progestin
nausea, breast tenderness, hyperpigmentation, migrane frequency, cholestasis, GB disease, HTN

27
Q

CI for theraputic estrogens

A 
Estrogen dependent neoplasms
genital bleeding
liver disease
thromboembolic disorder
heavy smokers
CV disease
28
Q

Normal fxns of progesterone

A

made during luteal phase - decrease GnRH pulses
decreases estrogen driven endometrial proliferation
decline at end of cycle causes menes
maintains pregnancy and mammary gland dev

29
Q

AE of progenstin

A

breakthrough bleeding with Ponly BC
minor increase in BP
HRT may increase breast cancer risk(protects endometrial)
androgenic effects

30
Q

Why so many progestins varieties?

A

Have a variety of pharmacokinetic effects

- estrogenic, androgenic, antiestrogenic, antiandrogenic, anabolic

31
Q

Progestin only Injectible preparations

A

Medroxyprogesterone acetate
injected IM every 3 months
fertility takes 6-18 months to return

32
Q

Progestin only IUDs

A

Levonorgestrel
5-7 years effective
rapid return to fertility

33
Q

Progestin only implantable

A

Etonogestrel
upper arm - good for 3 years
bleeding abnormalities are common
rapid return to fertility

34
Q

Combination transdermal preparations

A

Ethinyl estradiol and norelgestromin
new patch per week 3 weeks then 1 week off
same AE as COC - breast discomfort, dysmenorrhea

35
Q

vaginal contraceptive ring

A

ethinyl estradioal and etonogestrel
ring in 3 weeks out 1 week
rapid return to fertility

36
Q

Pregnancy termination

A

mifepristone (RU-485)
progesterone receptor antagonist - induces luteolysis
95% effective if given during first 7 weeks
AE prolonged bleeding - given in a clinic by a doc

37
Q

Morning after (plan B)

A

Levonorgesterel (plan B)
progesterone receptor agonist - unknown MOA
does not reverse pregnancy
more effective than combinations less N/V

38
Q

Morning after (ella)

A

ulipristal acetate
as effective as levonorgesteral in first 3 days
more effective days 3-5
may interfere with established pregnancy

Repro Exam I (7 decks)

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