Fellows DSAs

Question 1

Melanocytic nevus (typical mole)

Answer 1

inc risk melanoma

Ras or BRAF mutation

P16/INK4a (inhibit CKD4/6) accumulation

Question 2

Felty Syndrome

Answer 2

RA, Splenomegaly, Neutropenia

Question 3

dysplastic nevus syndrome

Answer 3

CDKN2A LOF loss of growth arrest or CDK4 mutation

most never progress

Question 4

melanoma

Answer 4

most sporadic UVR dmg to DNA, some inherited (AD)

Question 5

Lentigo maligna

Answer 5

older men, indolent, radial growth for years

hutchinson’s freckle

Question 6

superficial spreading melanoma

Answer 6

MC, radial growth for awhile

Question 7

flat dark lesion on extremities (soles, palms, subongal), dark skinned patients

Answer 7

acral lentiginous melanoma

C kit mutation

Question 8

Chr 9, p16, minor break

Answer 8

familial melanoma

Question 9

nodular melanoma

Answer 9

vertical growth, worst type (Breslow thickness)

Question 10

Actinic keratosis

Answer 10

sun damaged skin (face arm, dorsum of hands)

<1cm

excessive keratin forming cutaneous horn

thinning of epidermis

hyperkeratosis, dyskeratosis, parakeratosis, elastosis

Question 11

Hyperkeratosis, enlarged nuclei, keratin pearls, intercellular bridges, long time sun exposed skin

Answer 11

SCC

Question 12

palisading, resemble basal layer of epidermis, ulcerating lesions, pearly nodules w/ telangiectasia

Answer 12

MC invasive cancer in humans, locally aggressive

+ Hedgehog mutation (mutated PTCH) (active SMO)