Centrally Acting Muscle Relaxants Flashcards

1
Q
Baclofen
Carispordol
Cyclobenaprine
Diazepam
Tizanidine
A

Centrally acting spasmolytics

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2
Q

Glucocorticoids
Glatiramer acetate
INF1a, b
Mitoxantrone

A

Immunologic drugs for MS

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3
Q

Baclofen

A

GABAb R agonist: spasmolytic: MS or spinal disease

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4
Q

Carisprodol

A

CNS depressant: short term (2-3wk) MSK pain: schedule IV addictive

metabolized by CYP2C19: caution w/ CYP450s

metabolized to meprobamate (anxiolytic)

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5
Q

Cyclobenzaprine

A

reduce tonic motor activity via alpha and gamma motor neurons

antimuscarinic side effects

CYP450 metabolized

drowsy, dizzy, xerostomia

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6
Q

Diazepam

A

Promote GABA binding to GABAa receptor: anxiety or withdrawal treatment

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7
Q

Tizanidine

A

alpha2 adrenergic agonist

dec excitatory input to alpha motor neurons

treat muscle spasticity

drowsy, hypotension, dry mouth, muscle weakness

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8
Q

Glucocorticoids

A

monthly IV bolus methylpredniosne: MS

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9
Q

Glatiramer acetate

A

Mixture of L alanine, glutamic acid, lysine, tyrosine

similar antigenically to myeline basic protein

induce and activate T suppressor cells specific for myelin antigen: prevent presentation

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10
Q

INFs

A

BBB: interfere w/ T cell adhesion to endothelium

reduce relapse MS, reduce new T2 lesions, reduce Gd lesions, slow brain atrophy

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11
Q

Mitoxantrone

A

antineoplastic: MS

intercalates into DNA: cross links

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