Centrally Acting Muscle Relaxants Flashcards
Baclofen Carispordol Cyclobenaprine Diazepam Tizanidine
Centrally acting spasmolytics
Glucocorticoids
Glatiramer acetate
INF1a, b
Mitoxantrone
Immunologic drugs for MS
Baclofen
GABAb R agonist: spasmolytic: MS or spinal disease
Carisprodol
CNS depressant: short term (2-3wk) MSK pain: schedule IV addictive
metabolized by CYP2C19: caution w/ CYP450s
metabolized to meprobamate (anxiolytic)
Cyclobenzaprine
reduce tonic motor activity via alpha and gamma motor neurons
antimuscarinic side effects
CYP450 metabolized
drowsy, dizzy, xerostomia
Diazepam
Promote GABA binding to GABAa receptor: anxiety or withdrawal treatment
Tizanidine
alpha2 adrenergic agonist
dec excitatory input to alpha motor neurons
treat muscle spasticity
drowsy, hypotension, dry mouth, muscle weakness
Glucocorticoids
monthly IV bolus methylpredniosne: MS
Glatiramer acetate
Mixture of L alanine, glutamic acid, lysine, tyrosine
similar antigenically to myeline basic protein
induce and activate T suppressor cells specific for myelin antigen: prevent presentation
INFs
BBB: interfere w/ T cell adhesion to endothelium
reduce relapse MS, reduce new T2 lesions, reduce Gd lesions, slow brain atrophy
Mitoxantrone
antineoplastic: MS
intercalates into DNA: cross links