Feline bronchial disease Flashcards
sympathetic innervation
stimulation of Beta2 receptors leads to smooth relaxation
Bronchodilation
parasympathetic innervation
responsible for baseline tone
ACh–>increased intracellular calcium
stimulation leads to bronchoconstriction, mucus, cough
serotonin
released from feline mast cells
leads to bronchoconstriction
alpha adrenergic stimluation
decrease in cAMP
contraction of smooth muscles
inhibition of phosphodiesterase
increase in cAMP, cGMP
relaxation of smooth muscle
nitric oxide
endothelium-derived vasodilator
promotes bronchodilation
Which class of drugs is used to relax bronchial smooth muscle?
phosphodiesterase inhibitor
airway obstruction of asthma
hyperreactivity of bronchial smooth muscle
airway inflammation (bronchitis)
luminal bronchial secretions-goblet cell hyperplasia, musuc accumulation
extraluminal obstruction-emphysema, contributes to airway collapse
intramural changes-hypertrophy, fibrosis, edema, hyperplasia
Feline asthma
spontaneous bronchoconstriction associated with airway inflammation
reversible constriction
young adults, females>males, Siamese
etiology of feline asthma
type 1 hypersensitivity reaction
inhaled allergens, infectious agents, eosinophilia
idiopathic
hx and clincial signs of feline asthma
historical cough, normal between episodes
wheezing
sneezing
vomiting
acute respiratory distress
PE findings for feline asthma
tachypnea
dyspnea
wheezes
crackles
cough
normal PE
DDx for feline asthma
feline bronchial disease
layngeal disease
tracheal disease
heart disease-dyspnea, no cough
heartworm infection
pleural effusion
neoplasia
parasitic disease
pneumonia
Heartworm associated respiratory disease (HARD)
cough and dyspnea
due to arrival of immature heartworms in pulmonary vasculature and death of adult heartworms
Dx of feline asthma
administration of beta agonist if wheezing
chest rads
CBC-eosinophilia
Chem-increased TP
heartworm testing
fecal float
Airway wash