Feeding Hormones

Question 1

Glucagon-like peptide

Answer 1

• Co-secreted w/ PYY
• L cells
• Reduces food intake, supresses glucagon secretion, delays gastric emptying
• Incretin

Question 2

Oxyntomodulin

Answer 2

• Decreases gastric motility and secretions
• From L cells in response to ingested food
• Anorexic effect

Question 3

Pancreatic Peptide

Answer 3

• Decreases food intake via Y4R (in brainstem/hypo)

- May act via vagus n.

Question 4

Amylin

Answer 4

• Inhibits NPY release

- Pancreatic beta cells

Question 5

Glucagon

Answer 5

• Increases blood glucose and insulin

- Reduces food intake

Question 6

PYY

Answer 6

• L cells of ileum/colon
• Binds Y2R on NPY/AgRP to inhibit
• Releases inhibition of POMC neurons

Question 7

Insulin

Answer 7

• Binds insulin receptors in NPY/AGPR and POMC/CART

- Decreases appetite, increases metabolism

Question 8

Ghrelin

Answer 8

• Oxyntic cells of stomach
• Binds GHSR
• Stimulates neurons releasing NPY
• Increases appetite, gastric motility, gastric secretions
• Decreases insulin secretion

Question 9

Leptin

Answer 9

• Secreted by adipocytes
• Binds POMC/CART and NPY/AgRP
• Decreases appetite and ghrelin release
• Increases metabolism