FECES AND OTHER BODY FLUIDS Flashcards
Clinical significance of fecal analysis
Early detection of gastrointestinal bleeding
Liver and biliary duct disorders
Maldigestion or malabsorption syndromes
Inflammation
Causes of diarrhea
Identification of pathogenic bacteria and parasites
Normal fecal specimen composition
Water
Bacteria
Cellulose
Other undigested food stuffs
Gastrointestinal secretions
Bile pigments
Cells from the intestinal walls
Electrolytes
Final breakdown and reabsorption elements
Ingested proteins
Carbohydrates
Fats
Final breakdown and reabsorption site
Small intestine
Digestive enzymes elements
Trypsin
Chymotrypsin
Amino peptidase
Lipase
Digestive enzymes are secreted by the
Pancreas into the small intestines
Bile salts that help in fat digestion are provided by the
Liver
Any deficiency of the substances will result to [?] and the excess undigested or an absorbed material will [?]
Malbsorption or maldigestion
Appear in feces
The large intestine is capable of absorbing
~3000 mL or 3 L of water
Exceeds 3000 mL or 3 L of water
Diarrhea
When the fecal materials this a long time in the large intestine, it provides time for the additional water to be reabsorbed
Constipation
Brown color of the thesis results from the intestinal oxidation of [?] to [?], also from [?] to [?]
Stercobilinogen to Urobilin
Stercobilin to Hydrobilin
Increase in daily stool weight above 200 grams with increased liquidity and frequency of more than three times per day
Diarrhea
Diarrhea is classified according to
Duration of illness
Mechanism
(< 4 weeks)
Acute diarrhea
(> 4 weeks)
Chronic diarrhea
Increased secretion of water due to enterotoxin-producing organisms
Secretory diarrhea
E. coli, Clostridium, V. cholera, salmonella, shigella, staphylococcus, campylobacter, protozoa, and parasites such as cryptosporidium
Secretory diarrhea
Drugs
stimulant laxatives
hormones
inflammatory bowel disease (Chron disease, ulcerative colitis
lymphocytic colitis, diverticulitis)
endocrine disorders
neoplasms
collagen vascular disease
Secretory diarrhea
Where absorption due to incomplete breakdown (maldigestion) or reabsorption of food (malabsorption) which exerts osmotic pressure across the intestinal mucosa
Osmotic diarrhea
Causes:
Disaccharidase deficiency (lactose intolerance)
Malabsorption (celiac sprue)
Poorly absorbed sugars (lactose, sorbitol, mannitol)
Laxatives
Magnesium containing antacids
Amoebiasis
Antibiotic administration
Osmotic diarrhea
Fecal osmotic gap
Osmotic gap
Stool Na
pH
(-) reducing substances
Common fetal tests
Osmotic gap
Stool Na
pH
(-) reducing substances
Common fetal tests
Increase stool fat that exceeds 6 grams per day
Steatorrhea
Due to pancreatic insufficiency or disorders or to absence of bile salts
Steatorrhea
May also be present in malabsorption and maldigestion and can be distinguished by d xylose test
Steatorrhea
If d xylose is low, steatorrhea is caused by
Malabsorption
Causes of malabsorption
Bacterial overgrowth
Intestinal resection
Celiac disease
Tropical sprue
Lymphoma
Whipple disease
Giardia lamblia infestation
Chron disease
Intestinal ischemia