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Y3S2 - Foundations of Haematology > FBC Diagnosis Results > Flashcards

FBC Diagnosis Results Flashcards

1
Q

Ovalocytes and Hyper-Segmented Neutrophils

A

Megaloblastic anaemia

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2
Q

Microcytic and Normochromic - Further Tests

A

Use iron studies

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3
Q

Macrocytic and Hypochromic and Anaemia - Further Tests

A

Vitamin B12/folate assays

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4
Q

Leukemoid Reaction

A

Toxic granulation
Left shift
Marked neutrophilia
WBC usually > 30 x 10^9/L

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5
Q

Iron Deficieny Anaemia

A

Low Hb
Hypochromic
Ovalocytes

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6
Q

Inflammation (Sepsis)

A

Leukocytosis
Neutrophilia
Left shift
Monocytosis

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7
Q

Chronic Myelogenous Leukemia

A 
Neutrophilia (> 50%)
WBC: 12-1000 x 10^9/L
Left shift
< 2% blasts 
Concurrent eosinophilia/basophilia sometimes present
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8
Q

Acute, Severe Sepsis

A 
Leukopenia
Neutropenia
Lymphopenia
Left shift
Monocytopenia
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9
Q

What does only Monocytosis Indicate?

A

Chronic inflammation

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10
Q

Absolute Polycythaemia

A

Males:
Hct > 0.60 L/L
Females:
Hct > 0.56 L/L

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11
Q

Polycythaemia Vera

A

Increased RBC, Hb and Hct
Thrombocytosis
Middle aged to older adults

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12
Q

Differentiating Between the Myelocytes

A 
Myeloblast
- large
- nucleus takes up most of cell
- chromatin less condensed
- often have nucleolus
- sometimes have auer rods
Promyelocyte
- nucleus more condensed (oval)
- granules
- can be larger than myeloblast
- has nucleoli
Myelocyte
- smaller nucleus
- more condensed, course chromatin
- granules
- no nucleoli
Metamyelocyte
- indented nucleus (kidney shaped)
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13
Q

Acute Leukemia

A 
> 20% blast cells indicative of acute leukemia
Can have:
- anaemia
- thrombocytopenia
- neutropenia 
Further tests:
- immunophenotype
- karyotype
- molecular biology
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14
Q

Sepsis

A 
Variable leukocyte and neutrophil response
Left shift
Dohle bodies
Toxic granulation
Vacuolation
Presence of microorganisms
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15
Q

Anisocytosis and Poikilocytosis

A

Anisocytosis - variation in size

Poikilocytosis - variation in shape

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16
Q

Changes in MCV, MCHC and MCH and what they mean

A 
Greater than upper RI:
MCV - macrocytic
MCHC/MCH - hyperchromic
Less than lower RI
MCV - microcytic
MCHC/MCH - hypochromic
17
Q

Equations for RBC Values

A 
MCV = PCV/RCC
MCHC = Hb/PCV
MCH = Hb/RCC
PCV = MCV x RCC
18
Q

What does a microcytic anaemia indicate?

A

Potential iron deficiency due to reduced oxygen carrying capacity

19
Q

What does a macrocytic anaemia indicate?

A

Potential megaloblastic anaemia

Use intrinsic factor assay/bone marrow test to confirm

20
Q

CLL

A

> 50% lymphocytes
Prolymphocytes
Smudge cells

21
Q

Infectious Mononucleosis

A 
12-25 x 10^9/L WBC
> 50% lymphocytes
Reactive lymphocytes present
Confirmation with serology
- monospot test

Y3S2 - Foundations of Haematology (24 decks)

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