Fatty Acid Synthesis

Question 0

This system is present in many tissues, including liver,kidney, brain, lung, mammary gland, and adipose tis-sue. Its cofactor requirements include NADPH, ATP,Mn2+, biotin, and HCO3− (as a source of CO2). Acetyl-CoA is the immediate substrate, and free palmitate isthe end product.

Answer 0

Lipogenesis

Question 1

In bacteria and plants, the individual enzymes of thefatty acid synthase system are separate, and the acylradicals are found in combination with a protein calledthe _____

Answer 1

acyl carrier protein (ACP)

Question 2

NADPH generators:

Answer 2

Pentose phosphatepathway
Isocitrate
dehydrogenase
Malic
enzyme

Question 3

Rate limiting enzyme for lipogenesis

Answer 3

Acetyl coA carboxylase

Question 4

Final product of lipogenesis:

Answer 4

Palmitate

Question 5

Acetyl-CoA carboxylase is an allosteric enzyme and isactivated by_____ , which increases in concentration inthe well-fed state and is an indicator of a plentiful sup-ply of acetyl-CoA.

Answer 5

citrate