Fatty Acid metabolism Flashcards
1
Q
Location of FA synthesis
A
Cytosol of liver, mammary glands, adipose, and kidneys
2
Q
Substrates needed to make palmitate (16 C)
A
8 acetyl coA (1/2 of the carbons) + 14 NADPH + 7 ATP
3
Q
Step 1 substrate to get acetyl coA out of mitochondria
A
Citrate
4
Q
Step 2 conversion of acetyl coA into malonyl CoA
A
Acetyl coA carboxylase and biotin cofactor
5
Q
Step 2 conversion of acetyl coA into malonyl CoA
A
Acetyl coA carboxylase and biotin cofactor
6
Q
Step 3 linking of malonyl coA units
A
Fatty acid synthase (reduce, dehydrate, reduce)
7
Q
Purpose of carnitine shuttle
A
To get FA into the mitochondria for beta oxidation/ energy production
8
Q
Carnitine shuttle starting products
A
Lysine, methionine, ATP
9
Q
Carnitine shuttle location
A
Liver and kidneys
10
Q
Backbone of sphingolipids
A
Ceramide
