Cholesterol Synthesis

Question 1

Location of cholesterol synthesis

Answer 1

Liver cytosol

Question 2

Initial substrates of cholesterol synthesis

Answer 2

Acetyl coA and acetoacetyl coA

Question 3

Rate limiting enzyme and committing step of cholesterol synthesis

Answer 3

HMG CoA redactase (converts HMG CoA to mevalonate)

Question 4

First step of cholesterol synthesis

Answer 4

Acetyl coA to acetoacetyl coA by HMG coA synthase

Question 5

Process of cortisol excretion

Answer 5

Conjugation with glucuronic acid and sulfate in liver

Question 6

Liver and intestine generates (lipoprotein)

Answer 6

HDL- High cholesterol, lowest TAG

Question 7

VLDL generates

Answer 7

LDL- highest cholesterol, low TAG

Question 8

Liver generates

Answer 8

VLDL- high TAG, low cholesterol

Question 9

Intestine generates

Answer 9

Chylomicrons- highest TAG, lowest cholesterol

Question 10

Apo B100

Answer 10

Binds LDL receptor (VLDL, IDL, LDL)

Question 11

Apo B48

Answer 11

Mediates chylomicron secretion

Question 12

Apo E

Answer 12

Mediates remnant uptake (everything but LDL)