Fat transportation

Question 1

3 primary sources of fat?

Answer 1

Diet, de novo biosynthesis (liver- from scratch) and storage depots in adipose

Question 2

Where are bile salts generated and stored?

Answer 2

Liver and gallbladder

Question 3

Steatorrhea?

Answer 3

Undigested and unabsorbed fat resulting in fatty stool due to a lack of bile salts

Question 4

Orlistat?

Answer 4

Potent inhibitor of gastric and pancreatic lipases, reduces fat absorption by 30%. Treats obesity. Can produce abdominal pain, urgency to defecate and steatorrhea

Question 5

How are lipids transported around the body?

Answer 5

Lipids are transported in the plasma by lipoproteins

Question 6

Journey of CM’s?

Answer 6

Lacteals of intestine → thoracic duct → left subclavian vein to enter bloodstream

Question 7

Where is lipoprotein lipase located?

Answer 7

Capillary endothelial cells lining tissues including adipose, heart and skeletal muscle

Question 8

Why are HDL’s referred to as ‘good cholesterol’?

Answer 8

They help lower total serum cholesterol by taking cholesterol from peripheral tissues back to the liver (reverse cholesterol transport)

Question 9

Why are LDL’s referred to as ‘bad cholesterol’?

Answer 9

Prolonged elevation of LDL levels leads to atherosclerosis (hardening of the arteries). LDL’s mainly transport cholesterol esters.