Fat Soluble Vitamins Flashcards
1
Q
Primary function of Vit E
A
Antioxidant
2
Q
Biochemical importance of Vit E
A
- Stabilization of cell membrane
- Regulation of oxidation reactions
- Protection of PUFA , Vit A
3
Q
Least toxic vitamin
A
Vit E
4
Q
Deficiency of Vit E
A
Hemolysis of RBCs
Muscle breakdown
5
Q
Intestinal bacteria produce
A
Vit K 2
6
Q
Biochemical importance of Vit K
A
- Formation of gamma carboxyglutamate
( in the hepatic synthesis > prothrombin, blood clotting factors 2,7,9,10) - Helps the interaction of prothrombin with platelets
- Synthesis of osteocalcin(non collagenous) in bone , dentin
7
Q
Deficiency of Vit K
A
- impairment of blood clotting
- hemorrhagic disease of newborn ( sterile gut + not enough Vit K in mother milk)
8
Q
Vit K deficiency can occur in
A
Fat malabsorption
Newborn
Liver disease
Use of anticoagulant ( competitive inhibitors for Vit K )
9
Q
Toxicity of Vit K
A
Hemolytic anemia
Jaundice
10
Q
Most potent vit D metabolite
A
1,25-diOH-D3
11
Q
Biochemical role of Vit D
A
- Stimulates intestinal absorption of Calcium and phosphate by increased synthesis of specific ca-binding protein
- Reduces the renal excretion of ca
- Stimulates mobilization of Ca, P
12
Q
Deficiency of Vit D
A
- Rickets in children
- Osteomalacia in adults
- Renal rickets (renal osteodystrophy)
13
Q
Clinical indications
A
- Nutritional rickets
- Renal osteodystrophy
- Hypoparathyroidism
14
Q
Causes for Vit deficiency
A
- People are not exposed to sunlight
- Malabsorption of Vit D (obstructive jaundice and steatorrhea)
- Abnormality of vit D activation due to liver and renal disease or hypoparathyroidism
15
Q
Most toxic vitamin
A
Vit D
