Familial Breast Cancer Flashcards

1
Q

General

A

1 in 20 breast cancers due to inherited faults

1st degree - parents, siblings, children
2nd degree - grandparents, aunts and uncles
3rd degree - cousins, great aunts and uncles

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2
Q

Risk

A

High - >30% chance of developing breast cancer

Moderate - 17-30%

Population risk - < 17%

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3
Q

BRCA gene mutations

A

Autosomal dominant

BRCA1- chromosome 17
BRCA2 - chromosome 13

Genetic counselling before testing. Male carriers not offered screening. Higher risk of breast cancer in men with BRCA2 than 1

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4
Q

‘Enhanced screening’

A

Screening is performed every year rather than every 3

Screening involves MRI and mammography

Screening starts at younger age

No longer needed after bilateral risk-reducing mastectomy

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