Familial Breast Cancer Flashcards
1
Q
General
A
1 in 20 breast cancers due to inherited faults
1st degree - parents, siblings, children
2nd degree - grandparents, aunts and uncles
3rd degree - cousins, great aunts and uncles
2
Q
Risk
A
High - >30% chance of developing breast cancer
Moderate - 17-30%
Population risk - < 17%
3
Q
BRCA gene mutations
A
Autosomal dominant
BRCA1- chromosome 17
BRCA2 - chromosome 13
Genetic counselling before testing. Male carriers not offered screening. Higher risk of breast cancer in men with BRCA2 than 1
4
Q
‘Enhanced screening’
A
Screening is performed every year rather than every 3
Screening involves MRI and mammography
Screening starts at younger age
No longer needed after bilateral risk-reducing mastectomy
