Falls Flashcards
what ages should males and females be assessed for fracture risk?
females - 65 years
males - 75 years
consider between these ages and 50 years old in the presence of the following risk factors
- previous fragility fracture
- current or frequent use of glucocorticoids
- history of falls
- family history of hip fracture
how is the 10 year probability of a fragility fracture calculated?
using FRAX or QFracture risk tools
when should oral bisphosphonates be commenced relating to 10 years probability of fragility fractures?
10 year probability is at least 1%
when should IV bisphosphonates be commenced?
when 10-year probability of fragility fractures is at least 10%
or if a patient can not tolerate oral ones
name 2 medications as alternatives if a post menopausal women can not take bisphosphonates
- DENOSUMAB or - RALOXIFENE or - RANELATE
Mechanism of action of Raloxifene?
selective oestrogen receptor modulator
mechanism of action of strontium ranelate
increases deposition of new bone by osteoblasts ansd reduces the resorption of bone by inhibiting osteoclasts
mechanism of action of denosumab
human monoclonal antibody that inhibits RANK ligand which in turn inhibits the maturation of osteoclasts
name a contraindication of taking oral bisphosphonates?
swallowing problems or pre existing oesophageal disease e.g. barrets oesophagus
what is sarcopaenia?
reduction in muscle mass
by what mechanism does postural hypotension arise from?
reduced baroreceptor sensitivity with ageing
1st line investigations in a patient presenting with falls?
- blood glucose
- lying and standing blood pressure
- gain assessment
- ECG
history of intermittent vertigo, precipitated by change in head position
BPPV
benign, paroxysmal positional vertigo
Interventions (2) that have been shown to reduce both risk and rate of falls?
- exercise programmes; containing strength and balance training
- home hazard assessment
most common side effects of bisphosphonates?
heartburn and indigestion
when should oral bisphosphonate therapy be reviews?
3-5 years time