Fallopian tube/ovary pathology

Question 1

Answer 1

Fallopian tube

Question 2

Answer 2

Chronic Salpingitis

Question 3

Answer 3

Tubal invasive serous carcinoma

Question 4

Answer 4

Question 5

Types of Ovarian Surface Epithelial Tumors

Answer 5

Serous

Mucinous

Endometrioid

Clear cell tumors

Brenner tumor

Cystadenofibroma

Question 6

Are ovariant carcinomas sporadic or familial?

What age do ovarian surface epithelial tumors occur in?

Answer 6

Majority are sporadic/de novo

Only about 10% are familial/inherited

2/3 in reproductive age (80-90% in 20-65 years)

Question 7

What are some risk factors for surface epithelial neoplasms?

Answer 7

Increased risk: obesity, estrogen usage for >10 years, family history, germ line mutation in tumor suppressor genes

Reduced risk: high parity and use of oral contraceptives

Question 8

Answer 8

Ovarian surface neoplasm types

Benign – usually cystic (cystadenoma, cystadenofibroma)

Borderline – low malignant potential, solid/cystic

Malignant – solid cystic, 90% of ovarian malignancy

Question 9

Answer 9

High grade serous carcinoma – TP53 mutation

Most common ovarian epithelial tumors

60% benign, bilateral 25%, borderline 15%, malignant 25%

Question 10

Answer 10

Low grade serous carcinoma

KRAS, BRAF or ERBB2 mutations

Question 11

Answer 11

Serous Borderline Tumor

Question 12

Answer 12

Mucinous Tumors

80% benign

10% borderline

10% malignant

Multicystic, lined by mucin secreting cells

Mostly unilateral

Bilateral = metastasis until proven otherwise

Question 13

Answer 13

Endometrioid Tumors

Solid/cystic

May be associated with endometriosis

Usually malignant

Bilateral 30%

Concurrent endometrial carcinoma 15-30%

Mutation of PTEN suppressor gene

Question 14

Answer 14

Uncommon, solid

Usually unilateral

Incidental findings mostly with mucinous tumors

Nests of transitional type epithelium

Mostly benign

Borderline and malignant exist

Question 15

Answer 15

High grade serous carcinoma – Solid

Question 16

Answer 16

High grade serous carcinoma – Papillary

Question 17

Germ Cell Tumors

Answer 17

15-20% of ovarian tumors

younger age group

2-3% malignant = teratoma, dysgerminoma, yolk sak tumor, choriocarcinoma

Question 18

Answer 18

Mature Cycstic Teratoma

Question 19

Answer 19

Sex Cord-Stromal Tumors

8% of ovarian tumors

Composed of sex cord derivatives (granuloas and sertoli) and stromal derivatives (theca, lutein, Leydig cell)

Most common = Thecoma, fibroma, granulosa cell tumors

Question 20

Answer 20

Granulosa Cell Tumor

Can occur at any age (usually postmenopausal)

Granulosa cells in cords, sheets, strands

Mixture of lipid laden theca cells

Can mimic follicles – Call-Exner bodies

Usually estrogenic –> endometrial hyperplasia

Question 21

Answer 21

Metastasis from primary breast tumor