Fair Game Flashcards
Case 56
What do you do with CT contrast and Metformin to avoid contrast-induced nephropathy?
Hold Metformin for 48 hours
Check blood for signs of CIN
Restart if all is well
Case 56
What do you when there is CT contrast extravasation in the arm?
Elevate the arm Cold compress Call Surgeon - Lg vol high-osmolar contrast w necrosis - Neuromuscular dysfunction - Compartment Syndrome
Case 56
When does the severity of the soft tissue injury peak after contrast extravasation in an extremity?
48 hours
Case 56
How do you treat hives (urticaria) if Benadryl isn’t working?
Consider
- Cimetidine
- Epinephrine
Case 56
How do you treat a contrast reaction of hypotension with bradycardia?
Atropine
- Vasovagal reaction!
Case 56
How do you treat a contrast reaction of hypotension with tachycardia?
Trendelenburg position
IV fluids
Epinephrine
Case 56
How do you treat a contrast reaction of dyspnea?
Oxygen
Beta-agonist inhalants
Case 57
Name three causes of Medullary Nephrocalcinosis
Hyperparathyroidism
Renal Tubular Acidosis
Medullary sponge kidney
- typically unilateral
Case 57
Is renal function impaired with Medullary Nephrocalcinosis?
No (particularly if it is reversed) Unless - Severe, long-standing hypercalcemia and/or - Renal tubular acidosis
Case 57
What is the most common complication of Medullary Nephrocalcinosis?
Urolithiasis
Case 58
What GU tract anomalies are associated with ureteral duplication?
UPJ Obstruction
Hydronephrosis
Ureterocele
Ureterovesical reflux
Case 58
What is the Weigert-Meyer rule?
Upper pole ureter
- Inserts inferior and medial to the lower pole ureter
Upper pole moiety
- Obstructs
Lower pole moiety
- Refluxes
- Causes lower pole atrophy
Case 59
What is the conventional treatment for emphysematous pyelonephritis?
Radical nephrectomy
Drainage / Abx is Insufficient
Case 59
What type of patients are predisposed to emphysematous pyelonephritis?
What is the most common organism?
Diabetics
E. coli
Case 60
What mechanism causes a horseshoe kidney?
Arrest of cranial migration of the kidney by the IMA
Abnormal contact of the developing metanephric tissues
Case 60
What are common complications associated with horseshoe kidneys?
Nephrolithiasis
UPJ obstruction
Duplication anomalies
Recurrent infection
Higher susceptibility to renal injury from trauma
TCC (slight increase in incidence from urinary stasis)
Case 61
Dx of a solid, enhancing renal mass?
RCC
Oncocytoma
Lipid-poor angiomyolipoma
Metastasis
Case 61
What percentage of angiomyolipomas have no identifiable fat on CT or MRI?
What complication is AML associated with?
5%
Spontaneous Hemorrhage
Case 62
What percentage of angiomyolipomas are associated with tuberous sclerosis?
20%
Case 62
What size of an AML increases risk of bleeding?
What causes the tumor to bleed?
How do you deal with a nonhemorrhagic AML?
> 4cm
Small aneurysms develop in arteries supplying AML’s
Prophylactic excision, ablation, or embolization
Case 63
A patient with multiple AML’s likely has?
Tuberous sclerosis
Case 63
Three skin lesion associated with Tuberous Sclerosis?
Adenoma sebaceum (Adenofibroma)
Nevus depigmentosus
Cafe au lait spots
Case 63
What percentage of tuberous sclerosis patients have AML?
80%
Case 63
What are the 6 primary features of tuberous sclerosis?
(This to me is more of a neuroradiology question!)
Cortical tubers Giant cell astrocytoma Calcified subependymal nodules Retinal astrocytoma Facial angiofibromas Ungual fibromas
Case 64
What other renal masses besides angiomyolipoma can contain fat?
Angiomyolipoma Rarely - Lipoma - Liposarcoma - Wilms' tumor (dedifferentiated) - RCC that engulfs adjacent renal hilar fat
Case 65
Define a Bosniak I renal cyst and how do you manage it?
Simple cyst
- No follow-up
- Round
- Imperceptible wall
Case 65
Define a Bosniak II renal cyst and how do you manage it?
Minimally complex
- No follow-up
Case 65
Define a Bosniak IIF renal cyst and how do you manage it?
Minimally complex: 6 month follow-up >3cm >3 septa that are thicker or nodular Thick calcification Hyperdense but nonenhancing
Case 65
Define a Bosniak III renal cyst and how do you manage it?
Indeterminate
- 25-45% malignant
- Partial nephrectomy/RFA
- Multiple thick septations
- Coarse calcifications
- Hyperdense and enhancing
Case 65
Define a Bosniak IV renal cyst and how do you manage it?
Malignant
- Partial or total nephrectomy
- Solid and enhancing mass
- Cystic or necrotic components
Case 66
What renal tumor do patients with horseshoe kidneys more commonly have?
TCC
- Related to renal stasis
No increase in RCC incidence
Case 66
Why should you always perform an angiogram in patients who have horseshoe kidney and RCC?
Surgical planning
Almost always have
- Aberrant arterial supply
- Anomalous Venous drainage
Case 66
What pathology occurs with increased incidence in the setting of horseshoe kidney?
Infections
Stones
UPJ Strictures
TCC
Case 67
What are causes of spontaneous perinephric hemorrhage
Neoplasm (60%) Complicated renal cyst Vasculitis Infarction Infection
Case 68
DDx on U/S of a solid, heterogenous, hyperechoic mass (4 lesions)?
Renal cell carcinoma
Oncyocytoma
AML
Metastasis
Case 68
What differentiates Stage III from Stage IV RCC?
Stage III
- Regional lymph nodes
- Venous extension
Stage IV
- Direct invasion of adjacent organs (besides adrenal)
- Distant metastasis
Case 69
What are four causes of renal vein thrombosis?
RCC
Hyper coagulable state
Dehydration
Glomerulonephritis
Case 69
What has a better prognosis in Stage III RCC, venous extension or regional lymph node involvement?
Venous extension
Case 69
Why is it important to determine if renal venous tumor thrombosis with IVC thrombus extends above the level of the hepatic veins?
If it extends above the hepatic veins
- Abdominal incision isn’t enough for resection
- Requires thoracoabdominal incision w/ cardiopulmonary bypass
Case 70
What three diseases are associated with renal cysts and solid renal masses?
Tuberous sclerosis
von Hippel-Lindau Disease
Long-term dialysis
Case 70
What are common manifestations of vHL Disease
Retinal angiomas Renal cysts RCC (clear cell variety) Pancreatic cysts and cystic tumors Cerebellar hemangioblastomas
Case 70
A patient with multiple renal cysts. What helps differentiate the cause between ADPKD v. vHL Disease
If they have pancreatic cysts, it’s most likely vHL.
Patients with ADPKD don’t get pancreatic cysts
Case 71
What tumors grow in the kidney in an infiltrative pattern?
Urothelial tumors (TCC or SCC)
Metastasis
Lymphoma
Infiltrative RCC
Case 71
What are common causes of bilateral or multiple renal solid masses?
Metastasis
Oncocytoma
Lymphoma
AML
Multifocal RCC
Case 72
What two renal lesions are common in patients with tuberous sclerosis?
AML
Renal cysts
Case 73
A solid renal mass with a central stellate scar (spoke-wheel on angiography) is diagnostic of an oncocytoma. T or F?
False
- Highly suggestive
- Not diagnostic
- May be RCC
This is a surgical lesion! Biopsy won’t help. Take it out!
Case 74
DDx of bilateral infiltrative renal lesions (tumors and nontumors)?
Metastasis
Lymphoma
Infarcts
Pyelonephritis
Case 75
What are four ways that lymphoma involving the kidneys presents?
Perirenal space spread from retroperitoneum
Multifocal infiltrative renal masses
Diffuse renal infiltration
Solid renal mass (mimics RCC)
Case 75
How can ureteral position help differentiate lymphoma from retroperitoneal fibrosis
Lymphoma
- Lateral ureteral displacement
RPF
- Medial ureteral displacement
Case 75
What type of lymphoma involves the kidneys?
Non-Hodgkins Lymphoma
Case 76
What helps differentiate a right perinephric abscess caused by a perforated duodenal ulcer from pyelonephritis?
Normal cortical enhancement is unusual in pyelonephritis
Case 77
When you see a rim of enhancement around a renal cortical infiltrative abnormality, what is the likely diagnosis?
Renal infarct
The rim is caused by flow from the renal capsular artery
Case 78
What causes a “faceless kidney,” which is defined as a sold mass proliferating the renal sinus and obliterating its fat?
Transitional cell carcinoma
Squamous cell carcinoma less commonly
Case 79
What is the mechanism of developing xanthogranulomatous pyelonephritis (XGP)?
Recurrent upper urinary tract infections
- E. coli or Proteus
Calculus formation
- Obstruction
Renal inflammation with lipid-laden histiocytes
Destruction and replacement of renal parenchyma
Case 79
What patients are most susceptible to XGP?
Middle-aged women
Diabetics
Case 80
What mechanism causes a urinoma?
Laceration of the ureter at the UPJ
Case 80
How is a urinoma treated non-surgically to allow the ureteral laceration to heal?
Percutaneous nephrostomy
Ureteral stent
Case 80
What is a Page kidney?
Renovascular hypertension
- Subcapsular fluid (or hematoma)
- > Compresses renal parenchyma
- > Underperfusion and ischemia
- > Triggers renal renin-angiotensin-aldosterone system
- -> HTN
Case 80
What is a Goldblatt kidney?
Renovascular hypertension
- Caused by renal artery stenosis or occlusion
Case 81
What are two ways that a subcapsular hematoma can be distinguished from a hematoma in the peritoneal space?
Subcapsular hematoma deforms the renal shape
- No fat plane between the hematoma and the kidney
Case 81
Name 3 causes of a subcapsular hematoma
Trauma (blunt or biopsy)
Vasculitis
Vascular malformation
Case 82
What are known complications of renal biopsy?
Hemorrhage Abscess
Hematuria Sepsis
AV fistula Page Kidney
Case 82
What are 5 entities that are bright on T1 weighted MRI
Fat Methemoglobin
Melanin Gadolinium
Protein
Case 82
What are two risk factors for post-biopsy bleeding?
Coagulopathy
Severe hypertension
Case 83
Besides RCC, Dehydration, and Hypercoagulability, what are other less common causes of renal vein thrombosis?
Sickle cell disease
Vasculitis
Amyloidosis
Lupus
Case 83
What percentage of patients with renal vein thrombosis develop PE?
33%
Case 84
What % of patients on long-term dialysis develop RCC?
7%
RCC in these patients is typically less aggressive
Case 84
What is also common in long-term dialysis patients?
Multiple renal cysts
Case 85
T/F
Bilateral orthotopic uretereoceles are not associated with other urinary tract anomalies.
True
- Ectopic ureteroceles are however
Case 85
Ureteroceles >2 cm have a higher risk of what complications?
Urinary stasis
Obstruction
Stone formation
Infection
Case 85
What is the maximum thickness of the radiolucent halo around an orthotropic ureterocele?
Failed resorption of what structure is the proposed cause of this abnormality?
2 mm
Chwalla’s membrane
Case 86
What is a ureterocele-like abnormality with an irregular wall surrounding its bulbous portion or a thick halo (>2mm)
Pseudoureterocele
Case 86
What causes a Pseudoureterocele?
Ureteral stones
Edema from a recently passed ureteral stone
Manipulation of the UVJ
Bladder tumor blocking the ureteral orifice
Case 87
What is an amputed calyx on an IVP or CT urogram?
Abrupt cutoff of the infundibulum with minimal opacification of the calyces
Case 87
DDx of an amputed calyx on an IVP or CT urogram
TCC
TB
Case 88
What percentage of patients with calyceal TCC have synchronous tumors of the calyces?
Bladder?
25%
40%
Case 89
What is the single most important risk factor for TCC?
Smoking
Case 89
How does TCC typically present?
Hematuria (72%)
Dull pain (22%)
Renal colic due to obstruction
- Rare
Case 90
What is a Goblet sign?
Ureteral dilation below a radiolucent filling defect
Case 90
A “Goblet sign” is pathognomonic for what diagnosis?
Papillary TCC
Case 90
What causes the ureter to dilate with a TCC giving the appearance of a goblet?
Long-standing, slowly growing polypoid mass that is continuously being pushed down by peristalsis
Case 91
DDX of multiple ureteral filling defects on IVP
Uric acid stones Blood clots
Air bubbles Infectious debris (fungal)
Multifocal TCC (1/3 of patients) Sloughed papillae
Case 91
What percentage of TCC is Papillary?
67%
Case 92
Explain forniceal rupture related to a ureteral stone.
Spontaneous rupture of a calyceal fornix
Relief or “pop-off” valve reducing pressure
Contrast or urine extravasates into the perirenal space
Case 92
How does a fornix rupture present?
Is it an emergency?
Sudden relief of obstructive symptoms
It is a totally benign entity of no clinical significance
Case 93
T/F
Renal stones are the most common cause of transplant kidney hydronephrosis?
False
Stones only account for 2% of post-transplant hydro
Case 93
What are causes of transplant kidney hydronephrosis?
Anastomotic stricture
Blood clot
Ureteral edema
Pertransplant fluid collection (lymphoceles)
Case 93
How do you treat transplant kidney hydronephrosis?
Is the hydronephrosis symptomatic?
Percutaneous nephrostomy
Placement of a nephrovesical stent
No - painless in transplant kidney
Case 94
What is the likely cause of hematuria in a patient with hematuria and large filling defect in the kidney on IVP?
TCC
RCC
Vascular malformation
Case 94
What enzyme in urine leads to rapid change of pyelocalyceal blood clots?
Urokinase
Case 95
How do you best diagnose a traumatic ureteral injury?
CT Abdomen/Pelvis with IV only
Early and delayed images
Case 95
What are typical CT findings of ureteral injury?
Normal renal enhancement
Medial perirenal contrast extrav
Nonopacification ipsilateral distal ureter
Case 95
What is the best treatment for ureteral injury?
Percutaneous nephrostomy Nephroureteral stent placement Percutaneous urinoma drainage NOT surgery - They don't do as well
Case 96
DDX for distal ureteral stricture
Extrinsic compression ->Tumor Periureteral inflammation -> Appendicitis, IBD, Endometriosis Iatrogenic stricture Infection ->TB or Schistosomiasis Radiation
Case 96
How do you treat distal ureteral stricture?
Stent placement
Balloon dilation
Surgical resection
Case 97
What is a retrocaval ureter?
Abnormal course of the ureter posterior to the IVC
- Caused from anomalous development of IVC
Case 97
What defines medial displacement of the ureter?
The ureter courses medial to the L3 or L4 pedicle
Case 97
DDX for medial displacement of the ureter
Retroperitoneal fibrosis
Retroperitoneal mass
Prior surgery
Retrocaval ureter
Case 98
Where do most bladder tumors occur?
Posterolateral wall near the trigone
Case 98
What are the most common bladder tumors
TCC: 90%
SCC: 5%
Adenocarcinoma: 2%
Case 98
What predispose a patient to bladder squamous cell CA?
Schistosomiasis
Neurogenic bladder
Chronic Foley catheterization
Case 98
What is the most important prognostic factor for bladder cancer
Depth of bladder wall invasion (T2 or T3)
Treated with bladder cystectomy, not transurethral resection
Case 99
What causes bladder diverticula to develop?
Chronic bladder outlet obstruction
Case 99
What are common complications of bladder diverticula?
Chronic ureteral obstruction
Stones
Infection
Tumor