Factors affecting wound healing Flashcards
what are systemic factors that affect wound healing?
- nutrition
- obesity
- vascular status
- meds
- disease/co-morbidities
- age
- behavior
- psychological
What does malnutrition cause in regards to:
- Strength
- Response to stress
- decreased strength
- poor response to stress
Why are patients with wounds more prone to becoming malnourished?
Due to catabolic state of wound
What are the benefits of protein in your diet?
- affects cell repair & regeneration
- acts as enzymes to facilitate chemical reaction throughout the body
- are components of antibodies and are essential to immune system functioning
- acts as hormones and serve in important regulatory functions
- help transport lipids and other substance in the blood & across cell membranes
How does protein in your diet affect cell repair & regeneration?
provide amino acid building blocks for growth, repair/remodeling/maturation, and maintenance of tissues
Why is obesity a systemic factor?
- high body fat & poor nutritional status
- high rate of delayed healing, wound dehiscence & infection
- poor blood supply to adipose tissue
- increased workload of the heart
- edema difficult to assess
- co morbidities
What does arterial insufficiency cause in regards to:
- O2 to wound
- susceptibility to infection
- decreased oxygen to wound
- increase susceptibility to infection
- chronic non-healing wounds
What does venous insufficiency cause?
- edema
- fibrin in tissue spaces
- high risk of infection
What effect does steroids have on the body?
- decrease collagen synthesis
- suppress immune system
What effect does chemotherapeutic agents have on the body?
- interfere with cell proliferations
- prolong inflammation
- inhibit protein & fibroblast collagen synthesis
What effects does prolonged and increased NSAID use have on the body?
- vasoconstriction
- suppress inflammation & collagen synthesis
What does antineoplastic drugs affect?
fibroblast production
What does diabetes cause?
- accelerated atherosclerosis
- neuropathy
- abnormal collagen synthesis
what does vascular diseases cause?
- decreased blood supply
- oxygen perfusion & tissue oxygenation
What does renal dysfunction cause?
decreased ability to create granulation & fibroblasts
