Factors Affecting Bioavailability Flashcards

1
Q

Name some factors affecting bioavailability

A

Pharmaceutical factors
GI absorption
Presystemic metabolism

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2
Q

Factors affecting GI absorption

A

GI motility
Splanchic blood flow
Particularly size & formulation
Physiochemical factors

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3
Q

What can cause gastric stasis

A

Migraine

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4
Q

Particle formulations that can affect absorption

A

Tablet/capsule
Coating
Slow/fast release

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5
Q

Name a drug drug interaction

A

Tetracycline precipitates with calcium

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6
Q

I’m presystemic metabolism what is inactivated in gastric acid

A

Insulin

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7
Q

I’m presystemic metabolism what is metabolised in gut wal

A

Monoamines by MAO

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8
Q

Problems with transdermal

A

Multiple application a day
Differences in area of skin covered
Differences in thickness applied

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9
Q

What drugs are given transdermally

A

Ones with side effects
Ones that cause gastric irritation
Ones that require frequent dosing due to half life

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10
Q

Fastest and most certain route

A

Single bolus IV injection
100% bioavailability

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11
Q

What is advantage of steady IV infusion

A

Avoids high peak plasma conc
(Diazepam)

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12
Q

What is intrathecal

A

Injection into subarachnoid space via lumbar puncture needle
-aminoglycoside antibiotics
-local anaesthetics

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13
Q

What is inhalation advantageous

A

Direct delivery to site of action
Rapid action
Minimise systemic absorption
Minimise side effects

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14
Q

How much inhaled drug reaches airway

A

10-20%

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15
Q

How can u make an inhaled drug slow release

A

Liposome encapsulation

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