Factors

Question 1

Factor I - Fibrinogen

Answer 1

Source: Liver

Common pathway; converted to fibrin (insoluble weblike substance of clot)

Question 2

Factor II - Prothrombin

Answer 2

Source: Liver (synthesis requires vit.K)

Common pathway; converted to thrombin (converts fibrinogen to fibrin)

Question 3

Factor III - Tissue Factor

Answer 3

Source: Tissue cells

Activates extrinsic pathway

Question 4

Factor IV - Calcium ions

Answer 4

Source: Plasma

Needed for essentially all stages of coagulation process; always present

Question 5

Factor V - Proaccelerin

Answer 5

Source: Liver, platelets

Common pathway

Question 6

Factor VII - Proconvertin

Answer 6

Source: Liver (synthesis requires vit.K)

Both extrinsic and intrinsic pathways

Question 7

Factor VIII - Antihemophilic factor (AHF)

Answer 7

Source: Liver, lung capillaries

Intrinsic pathway; deficiency results in haemophilia A

Question 8

Factor IX - Plasma thromboplastin component (PTC)

Answer 8

Source: Liver (synthesis requires vit.K)

Intrinsic pathway; deficiency results in hemophilia B

Question 9

Factor X - Stuart factor

Answer 9

Source: Liver (synthesis requires vit.K)

Common pathway

Question 10

Factor XI - Plasma thromboplastin antecedent (PTA)

Answer 10

Source: Liver

Intrinsic pathway; deficiency results in hemophilia C

Question 11

Factor XII - Hageman factor

Answer 11

Source: Liver

Intrinsic pathway; activates plasmin: initiates clotting in vitro; activation initiates inflammation

Question 12

Factor XIII - Fibrin stabilising factor (FSF)

Answer 12

Source: Liver, bone marrow

Cross-links, forming a strong, stable clot