Factors Flashcards
F2
Prothrombin, common pathway, thrombin precursor
F3
Tissue factor, tissue thromboplastin, extrinsic tenase complex cofactor, not in circulation
F4
Ionized calcium, activate thromboplastin and convert prothrombin to thrombin
F5
Labile factor, proaccelerin, needed to convert prothrombin to thrombin, common pathway, deteriorates and collected plasma and destroyed by clotting process
F7
Stable factor, proconvertin, extrinsic pathway, extrinsic tenase complex, not destroyed during clotting
F8
Anti-hemophilic factor, in circulation as F8 and VWF complex, with two subunits, S8: C and F8: VWF, intrinsic pathway
F9
Christmas factor, plasma thromboplastin component, intrinsic thromboplastin generating system, mediates platelet adhesion to vessel walls via and intracellular bridge
F10
Stuart prowler factor, common pathway, prothrombinase complex
F11
Plasma thromboplastin antecedent, circulates as complex with high molecular weight killikrein, intrinsic thromboplastin generation
F12
Hagemann factor, contact factor, intrinsic pathway, converts to active form when it contacts glass, or any negatively charged surface
F13
Fibrin stabilizing factor, enzyme that catalyzes fibrin polymerization, involved in tissue growth/repair by linking endothelial cells to collagen/fibrin residue
HMWK
Fitzgerald factor, intrinsic pathway, cofactor in reactions with facture 12 and activation of factor eight
Fletcher Factor
Prekillikrein, intrinsic pathway, kallikrein precursor, activates plasminogen
F1
Fibrinogen, common pathway, fibrin precursor, high molecular weight, principal substrate of coagulation and fibrinolytic factors
Which factors are serine proteases?
Kallikrein, 12, 11, 9, 10, 7, thrombin
