Factor def. Anemias Flashcards
factor def. anemias are a result of
lack of available the raw materials necessary for the process of hematopoiesis
not usually a dietary lack so much as a demand need
factors necessary for Hb synthesis
iron
B12
folic acid
pyridoxine
cells smaller than normal
Hb molecule defect due to a lack of iron
most common cause is iron def. (IDA)
microcytosis
in microcytosis:
MCV ____
MCHC ____
MCV: decreases
MCHC: decreases
as microcytosis evolves over time…
serum ferritin: decreases
microcytosis
hypochromia
SI___/TIBC___:
normal, hemochromatosis, iron overload, pyridoxine def. or other sideroblastic anemias, hemolysis
SI: increased
TIBC: decreased
SI____/TIBC___:
chronic IDA, later pregnancy
SI: decreased
TIBC: increased
SI___/TIBC___:
BCPs, hepatitis
SI: increased
TIBC: increased
SI____/TIBC____:
chronic dz, uremia
SI: decreased
TIBC: decreased
necessary for the development of heme
decreased by meds, alcohol, stress, diet
pyridoxine
PD in SI ______ and TIBC _____
SI: increased
TIBC: decreased
cells larger than normal
due to def. of B12 or folic acid
megaloblastic changes
macrocytosis
found in foods of animal origin: dairy, meat, and egg products
cyanocobalamin
def. develops from
inability to absorb due to lack of intrinsic factor
autoimmune antibodies damage parietal and chief cells
lack of gastric acid
malabsorption syndromes involving the terminal ileum
surgery of distal small intestine
macrocytosis
macrocytosis: dietary def. are _____ and found mainly in strict vegetarians
RARE
