F and CL part 3 Flashcards
1
Q
Bioavailability and Hepatic extraction ratio
A
F= Qh/ Qh+fu X CLint
2
Q
Low EH drugs
A
F is close to 1
F is affected by changes in CLint, fu, or QH
CLh is affected by changes in CLint or fu
3
Q
High EH drugs
A
F= QH/ fu X CLint
F is not affected by changes in CLint, fu, or QH
CLh is proportional to Qh
Changes in F significantly
4
Q
Factors affecting AUCiv
A
Low EH drug: fu and CLint
High EH drug: QH
5
Q
Factors affecting AUCpo
A
Low EH drug: fu and CLint
High EH drug: fu and CLint
6
Q
Filtration
A
from arterial bloodstream into glomerulus
Increase excretion
depends on MW and unbound drug concentration (fu)
CLr= fu X GFR
7
Q
Secretion
A
from arterial bloodstream into proximal tubule
increase excretion
CLR>fu X GFR
8
Q
Reabsorption
A
from lumen of nephron into venous bloodstream
Decrease excretion
