Eye and Vision Flashcards

1
Q

Describe the path of light through the eye

A

Enters through the iris
Focused byt the cornea and lens
Traversing the vitreous humour
Reaches the retina

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2
Q

Describe the cells making up the retina

A

Rods are highly light sensitive and are specialised for night vision (with the loss of rods leading to night blindness and loss of peripheral vision), converging into one single bipolar cell.

Cones are concentrated in the fovea, providing high acuity vision, day vision, and colour vision. There are three types of cone (blue, red, and green) and, unlike the rods, they have a one cone to one interneurone interaction.

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3
Q

What are the functional classes of cells in the retina?

A

Photoreceptors, interneurones (bipolar, horizontal and amacrine cells) which combine the signals from the photoreceptors, and ganglion cells (magnocellular (M) and parvocellular (P)) that are the output cells of the retina. These nerves will then enter the visual pathway.

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4
Q

What is the visual field?

A

The visual field of each eye is the region of space that the eye can see looking straight ahead without movement of the head.

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5
Q

Describe how the retina can be divided and where the visual fields are detected.

A

The retina can be divided up into two halves by a vertical imaginary line through the centre of the fovea, known as the nasal hemiretina and the temporal hemiretina (these can also be divided into superior and inferior with a horizontal imaginary line).

Due to the action of light passing through the lens, image present on the left of the visual field are detected by the nasal hemiretina of the left eye and temporal hemiretina of the right eye, and vice versa; a similar relationship occurs with the superior and inferior halves of the retina.

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6
Q

Describe the visual pathway.

A

• Each retina is supplied by nasal and temporal fibres
o Nasal fibres are found in the medial retina, they supply our temporal visual fields
o Temporal fibres are found in the lateral retina, they supply our nasal visual fields
• The temporal fibres run ipsilaterally – they don’t cross at the optic chiasm
• The nasal fibres cross at the optic chiasm
• After the optic chiasm the fibers form the optic radiations – parietal and temporal
• The fibres converge at the occipital lobe in the visual cortex

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7
Q

Describe the muscles of the eye, their movements and innervation.

A

• Oculomotor nerve (CNIII) innervates
o Superior rectus, elevates, adducts, incyclotorsion
o Inferior rectus - depression, excyclotorsion, adduction
o Medial rectus, adduction
o Inferior oblique - excyclotorsion, elevation, abduction
Levator palpebrae superioris - elevation/retraction of eyelid

• Trochlear nerve (CNIV) innervates
o Superior oblique, incyclotorsion, depression, abduction

• Abducens nerve (CNVI) innervates
o Lateral rectus, abduction

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8
Q

Describe what occurs in CNIII palsy. What are causes?

A

Ptosis
Down and out
Dilated pupil

Causes:
o Posterior communicating artery aneurysm
o Diplopia and dilated pupil is most common presentation
o Vasculopathies – diabetes/hypertension
o Idiopathic

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9
Q

What occurs in CNIV palsy? What are the causes?

A

Up and in due to unopposed inferior oblique action
Subtle head tilt as superior oblique has role in eye rotation

Causes:
o	Head trauma – closed head injuries
•	CNIV is the thinnest cranial nerve
•	CNIV has a long course inside the cranium
o	Tumours
o	Congenital
•	Unknown mechanism
•	Possibly aplasia of CNIV nucleus
o	Vasculopathies e.g. Diabetic
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10
Q

Describe CNVI palsy.

A

Inability to abduct the affected eye

Causes:
o	Raised ICP
•	Tortuous course of CNVI inside cranium
o	Pontine tumours
o	Vasculopathies e.g. Diabetic/hypertension
o	Idiopathic
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11
Q

Describe the pupillary light reflex.

A

o Light stimulates the afferent nerve (CNII)
o Synapses at the midbrain (in the pretectal area) onto neurons that supply the Edinger-Westphal nucleus bilaterally
o Stimulates CNIII bilaterally, causes direct and consensual pupillary constriction.

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12
Q

Describe the accommodation reflex.

A

o Required for near vision:
• Pupils converge (medial rectus)
• Pupils constrict (constrictor pupillae)
• Increase convexity of the lens, increasing refractive power (ciliary muscle)
o It involves the cerebral cortex as it is related to image analysis
• It follows the visual pathway via the lateral geniculate nucleus to the visual cortex, then returns via the edinger-westphal nucleus like the light reflex.

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13
Q

Describe the classification of visual field defects

A
•	Before the optic chiasm:
o	Signs are unilateral and ipsilateral
•	At or after the optic chiasm
o	Signs are bilateral
•	After the optic chiasm
o	Signs will be contralateral
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14
Q

What is monocular blindness due to? Causes?

A

Vision in only one eye
o Due to a lesion of the ipsilateral optic nerve
o Causes:
• Optic nerve glioma or retinoblastoma in children
• Optic sheath meningioma (middle age)

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15
Q

What is bitemporal hemianopia. Causes?

A

Tunnel vision
Lesion at the optic chasm which affects both nasal fibres - so both temporal fields are lost

Causes include pituitary tumour, anterior communicating artery aneurysm

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16
Q

What is left homonymous hemianopia? Causes?

A

o Lesion at the right optic tract – affects the left nasal and right temporal fibres
• Which means loss of the left temporal and right nasal visual fields
o Causes include vascular (stroke) – by far the most common. Also neoplasia, trauma

17
Q

What is right homonymous hemianopia?

A

o Lesion of the left optic tract
o Affecting left temporal and right nasal fibres
Which means loss of the right temporal and left nasal visual fields

18
Q

What is macular sparing?

A

o Macular sparing occurs due to the areas of the visual cortex receiving blood from both calcarine artery and collateral branches of the middle cerebral artery, allowing for the integrity of the caudal parts of the visual cortex to be preserved despite any occlusion of the calcarine artery.

o Occipital lobe has a dual blood supply (since central vision is so important for survival)
• Posterior cerebral artery supplies the entire lobe
• Middle cerebral artery supplies the occipital pole

o So if you have a stroke affecting the PCA the occipital pole (which represents the macula) will be spared and so you will retain central vision.

o Also the macula has a large representation in the cortex – so you’d have to lose a lot of brain

19
Q

What is the blood supply to the occipital lobe?

A
  • Posterior cerebral artery supplies the entire lobe

* Middle cerebral artery supplies the occipital pole

20
Q

When can you get homonymous superior/inferior quadrantanopia? Cause?

A

• You can also get homonymous superior or inferior quadrantanopia if there are lesions in the optic radiations.
o Damage to the right temporal lobe (including Meyer’s loop) will cause vision to be lost in the superior quadrant of the left visual hemifield; this is called a superior left homonymous quadrantanopia. It commonly occurs through vascular occlusions in the middle cerebral artery causing lesions in the inferior half of the temporal lobe.

21
Q

Describe the anatomical course of the optic nerve.

A

Retina to primary visual cortex

Extracranial

  • Convergence of axons from retinal ganglion cells
  • Leaves orbit via the optic canal through sphenoid bone
  • Runs along surface of middle cranial fossa near to pituitary gland

Intragrania
- Optic nerves unite to form optic chiasm.
Fibres from the medial half of each retina cross over forming the optic tracts.

Left optic tract - contains fibres from the left temporal retina and right nasal retina

Right optic tract - contains fibres from right temporal retina and left nasal retina

Each tract travels to cerebral hemisphere to R/L lateral genicuulate nucleus (LGN) in thalamus and synapse

Optic radiations from LGN then carry fibres to visual cortex

Upper optic radiation – carries fibres from the superior retinal quadrants (corresponding to the inferior visual field quadrants). It travels through the parietal lobe to reach the visual cortex.
Lower optic radiation – carries fibres from the inferior retinal quadrants (corresponding to the superior visual field quadrants). It travels through the temporal lobe, via a pathway known as Meyers’ loop, to reach the visual cortex.

22
Q

How does pituitary adenoma affect the optic nerve and vision?

A

Within the middle cranial fossa, the pituitary gland lies in close proximity to the optic chiasm. Enlargement of the pituitary gland can therefore affect the functioning of the optic nerve.

Compression to the optic chiasm particularly affects the fibres that are crossing over from the nasal half of each retina. This produces visual defect affecting the peripheral vision in both eyes, known as a bitemporal hemianopia.

Surgical intervention is commonly required. To access the gland, the surgeon uses a transspehenoidal approach, accessing the gland via the sphenoidal sinus

23
Q

What do the upper and lower optic radiations carry?

A

Upper optic radiation – carries fibres from the superior retinal quadrants (corresponding to the inferior visual field quadrants). It travels through the parietal lobe to reach the visual cortex.

Lower optic radiation – carries fibres from the inferior retinal quadrants (corresponding to the superior visual field quadrants). It travels through the temporal lobe, via a pathway known as Meyers’ loop, to reach the visual cortex.